Table 1 A list of requirements to be fulfilled by the “ideal” antibacterial implant coating strategy
Requirements | Fulfillments | |||
|---|---|---|---|---|
Safety | No systemic toxicity | No local toxicity | No detrimental effects on bone healing | No unwanted long-term side effects |
In vitro activity | No cytotoxicity or genotoxicity | Proven bactericidal and antibiofilm activity on different surfaces | Large spectrum | No induction of resistance |
Efficacy | Proven in vivo | Case series | Multicenter trials | Randomized trials |
Ease-of-use | Easy handling | Versatility | Resistance to press-fit insertion | Storage |
Market | Acceptable cost | Large availability | Easy to manufacture | Overcomes regulatory issues |