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Table 2 Blood loss, length of hospital stay and complications after total hip arthroplasty

From: Bridging therapy for oral anticoagulation increases the risk for bleeding-related complications in total joint arthroplasty

 

UFH bridging

LMWH bridging

LMWH prophylaxis

p value

(n = 14)

(n = 9)

(n = 1494)

Blood loss

    

 Preop. haemoglobin level, mmol/L (range)

8.0 (6.1–9.4)

8.2 (5.9–9.6)

8.5 (5.3–11.1)a

0.313

 Postop. haemoglobin level, mmol/L (range)

5.0 (3.2–6.8)

6.0 (3.7–8.2)

6.5 (3.6–9.0)b

<0.001

 Haemoglobin decrease, mmol/L (range)

3.0 (0.4–5.3)

2.2 (0.3–5.2)

2.0 (0.3–5.3)c

0.044

 Transfusion units

Mean (range)

5.8 (0–25)

2.9 (0–18)

0.2 (0–6)

0.040

 

Median

4

0

0

 

 Bleeding index

Mean (range)

8.8 (0.4–30)

5.0 (0.3–22)

2.1 (0.3–9.3)c

0.027

 

Median

6.9

2.2

1.9

 

Hospital stay

    
 

Mean days (range)

23.9 (7–71)

9.9 (4–27)

6.8 (4–69)

0.009

 

Median

16

8

6

 

Complications

    

 Any complication

11 (79 %)

4 (44 %)

218 (14.6 %)

<0.001

 Bleeding-related complication

    

  Major bleeding

9 (64 %)

3 (33 %)

46 (3.1 %)

<0.001

  Minor bleeding

0

0

5 (0.3 %)

1.000

  Neuropraxia due to hematoma

3 (21 %)

1 (11 %)

0

<0.001

  Evacuation of hematoma

7 (50 %)

1 (11 %)

3 (0.2 %)

<0.001

 Thromboembolic complication

    

  Arterial thromboembolism

0

0

4 (0.3 %)

1.000

  Deep venous thrombosis

0

0

7 (0.5 %)

1.000

  Pulmonary embolism

0

0

3 (0.2 %)

1.000

 Heparin-induced thrombocytopenia

1 (7 %)

0

0

NAd

 Infected THA

1 (7 %)

0

13 (0.9 %)

0.194

 Death

0

2 (22 %)

4 (0.3 %)

0.001

  1. aTwenty-six values unknown
  2. bFour values unknown
  3. cTwenty-eight values cannot be calculated
  4. dNot applicable, number too small to perform statistics