UFH bridging | LMWH bridging | LMWH prophylaxis | p value | ||
---|---|---|---|---|---|
(n = 14) | (n = 9) | (n = 1494) | |||
Blood loss | |||||
Preop. haemoglobin level, mmol/L (range) | 8.0 (6.1–9.4) | 8.2 (5.9–9.6) | 8.5 (5.3–11.1)a | 0.313 | |
Postop. haemoglobin level, mmol/L (range) | 5.0 (3.2–6.8) | 6.0 (3.7–8.2) | 6.5 (3.6–9.0)b | <0.001 | |
Haemoglobin decrease, mmol/L (range) | 3.0 (0.4–5.3) | 2.2 (0.3–5.2) | 2.0 (0.3–5.3)c | 0.044 | |
Transfusion units | Mean (range) | 5.8 (0–25) | 2.9 (0–18) | 0.2 (0–6) | 0.040 |
Median | 4 | 0 | 0 | ||
Bleeding index | Mean (range) | 8.8 (0.4–30) | 5.0 (0.3–22) | 2.1 (0.3–9.3)c | 0.027 |
Median | 6.9 | 2.2 | 1.9 | ||
Hospital stay | |||||
Mean days (range) | 23.9 (7–71) | 9.9 (4–27) | 6.8 (4–69) | 0.009 | |
Median | 16 | 8 | 6 | ||
Complications | |||||
Any complication | 11 (79 %) | 4 (44 %) | 218 (14.6 %) | <0.001 | |
Bleeding-related complication | |||||
Major bleeding | 9 (64 %) | 3 (33 %) | 46 (3.1 %) | <0.001 | |
Minor bleeding | 0 | 0 | 5 (0.3 %) | 1.000 | |
Neuropraxia due to hematoma | 3 (21 %) | 1 (11 %) | 0 | <0.001 | |
Evacuation of hematoma | 7 (50 %) | 1 (11 %) | 3 (0.2 %) | <0.001 | |
Thromboembolic complication | |||||
Arterial thromboembolism | 0 | 0 | 4 (0.3 %) | 1.000 | |
Deep venous thrombosis | 0 | 0 | 7 (0.5 %) | 1.000 | |
Pulmonary embolism | 0 | 0 | 3 (0.2 %) | 1.000 | |
Heparin-induced thrombocytopenia | 1 (7 %) | 0 | 0 | NAd | |
Infected THA | 1 (7 %) | 0 | 13 (0.9 %) | 0.194 | |
Death | 0 | 2 (22 %) | 4 (0.3 %) | 0.001 |