Table 4 Pathway enrichment analysis of the down-regulated differentially expressed genes
Pathway | Term | Name | Count | Gene symbol | p value |
|---|---|---|---|---|---|
KEGG pathway | 4110 | Cell cycle | 21 | CCNA2, CCNB1, CCNB2, CCNE2, CDK1, CDKN2C, … | 2.35E−09 |
5322 | Systemic lupus erythematosus | 15 | H2AFX, H2AFY, HIST1H2AE, HIST1H2AM, … | 1.07E−04 | |
4114 | Oocyte meiosis | 13 | AURKA, CCNB1, CCNB2, CCNE2, CDK1, FBXO5, … | 1.86E−04 | |
4115 | p53 signaling pathway | 9 | CCNB1, CCNB2, CCNE2, CDK1, GADD45G, … | 7.05E−04 | |
30 | Pentose phosphate pathway | 5 | ALDOC, DERA, PFKP, PGM1, PRPS1 | 2.5E−03 | |
4914 | Progesterone-mediated oocyte maturation | 9 | CCNA2, CCNB1, CCNB2, CDK1, PLK1, … | 3.7E−03 | |
3030 | DNA replication | 5 | FEN1, LIG1, POLA2, POLE, POLE2 | 9.0E−03 | |
REACTOME pathway (top ten terms) | 1640170 | Cell cycle | 90 | AURKA, AURKB, CCNB1, CCNE2, CDK1, CENPA, CENPH, … | 0 |
2500257 | Resolution of sister chromatid cohesion | 34 | AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … | 0 | |
453277 | Mitotic M-M/G1 phases | 57 | AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … | 0 | |
68877 | Mitotic prometaphase | 39 | AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … | 0 | |
68886 | M phase | 48 | AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … | 0 | |
69278 | Cell cycle, mitotic | 79 | AURKA, AURKB, CCNB1, CCNE2, CDK1, CENPA, CENPH, … | 0 | |
2555396 | Mitotic metaphase and anaphase | 38 | AURKB, CENPA, CENPH, FBXO5, PLK1, PSMD1, … | 1.11E−16 | |
2467813 | Separation of sister chromatids | 36 | AURKB, CENPA, CENPH, PLK1, PSMD1, … | 4.44E−16 | |
68882 | Mitotic anaphase | 37 | AURKB, CENPA, CENPH, KIF2C, PSMD1, … | 4.44E−16 | |
69275 | G2/M transition | 23 | AURKA, CCNA2, CCNB1, CCNB2, CDK1, PLK1, PLK4, … | 6.87E−10 |