Skip to main content

Table 4 Pathway enrichment analysis of the down-regulated differentially expressed genes

From: Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines

Pathway Term Name Count Gene symbol p value
KEGG pathway 4110 Cell cycle 21 CCNA2, CCNB1, CCNB2, CCNE2, CDK1, CDKN2C, … 2.35E−09
5322 Systemic lupus erythematosus 15 H2AFX, H2AFY, HIST1H2AE, HIST1H2AM, … 1.07E−04
4114 Oocyte meiosis 13 AURKA, CCNB1, CCNB2, CCNE2, CDK1, FBXO5, … 1.86E−04
4115 p53 signaling pathway 9 CCNB1, CCNB2, CCNE2, CDK1, GADD45G, … 7.05E−04
30 Pentose phosphate pathway 5 ALDOC, DERA, PFKP, PGM1, PRPS1 2.5E−03
4914 Progesterone-mediated oocyte maturation 9 CCNA2, CCNB1, CCNB2, CDK1, PLK1, … 3.7E−03
3030 DNA replication 5 FEN1, LIG1, POLA2, POLE, POLE2 9.0E−03
REACTOME pathway (top ten terms) 1640170 Cell cycle 90 AURKA, AURKB, CCNB1, CCNE2, CDK1, CENPA, CENPH, … 0
2500257 Resolution of sister chromatid cohesion 34 AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … 0
453277 Mitotic M-M/G1 phases 57 AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … 0
68877 Mitotic prometaphase 39 AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … 0
68886 M phase 48 AURKB, CCNB1, CCNB2, CDK1, CENPA, CENPH, … 0
69278 Cell cycle, mitotic 79 AURKA, AURKB, CCNB1, CCNE2, CDK1, CENPA, CENPH, … 0
2555396 Mitotic metaphase and anaphase 38 AURKB, CENPA, CENPH, FBXO5, PLK1, PSMD1, … 1.11E−16
2467813 Separation of sister chromatids 36 AURKB, CENPA, CENPH, PLK1, PSMD1, … 4.44E−16
68882 Mitotic anaphase 37 AURKB, CENPA, CENPH, KIF2C, PSMD1, … 4.44E−16
69275 G2/M transition 23 AURKA, CCNA2, CCNB1, CCNB2, CDK1, PLK1, PLK4, … 6.87E−10
  1. KEGG Kyoto Encyclopedia of Genes and Genomes