Table 1 Bone infection, treatment, and 18F-FDG PET/CT scan findings in rabbit model of S. aureus osteomyelitis
Animal number | Day 21 | Day 0 | Tx | Duration of treatment (weeks) | Day 7 of treatment/follow-up | Day 14 of treatment/follow-up | Day 21 of treatment/follow-up | Day 42 of treatment/follow-up | Bone infection at the end of treatment/follow-up | |
|---|---|---|---|---|---|---|---|---|---|---|
Inoculum | Bone infection | PET/CT (SUVmax) | PET/CT (SUVmax) | PET/CT (SUVmax) | PET/CT (SUVmax) | PET/CT (SUVmax) | ||||
706 | Saline | No | Neg | No | – | Neg | Neg | – | – | No |
693 | Saline | No | Neg | No | – | – | – | Neg | Neg | No |
700 | S. aureus | No | Neg | No | – | – | – | – | – | – |
701 | S. aureus | No | Neg | No | – | – | – | – | – | – |
698 | S. aureus | Yes | Pos (2.6) | Yes | 1 | Pos (3.9) | – | – | – | Yes |
699 | S. aureus | Yes | Pos (4.1) | Yes | 1 | Pos (4.8) | – | – | – | Yes |
702 | S. aureus | Yes | Pos (3.2) | Yes | 1 | Pos (5.3) | – | – | – | Yes |
703 | S. aureus | Yes | Pos (2.6) | Yes | 1 | Pos (2.3) | – | – | – | Yes |
707 | S. aureus | Yes | Pos (1.7) | Yes | 1 | Pos (2.0) | – | – | – | Yes |
695 | S. aureus | Yes | Pos (1.8) | Yes | 3 | – | – | Pos (3.9) | – | Yes |
694 | S. aureus | Yes | Pos (3.5) | Yes | 3 | – | – | Pos (1.8) | – | Yes |
692 | S. aureus | Yes | Pos (1.4) | Yes | 3 | Pos (1.5) | Pos (1.6) | Neg (0.8) | – | No |
704 | S. aureus | Yes | Pos (1.9) | Yes | 3 | Pos (3.6) | – | Pos (3.8) | – | Yes |
705 | S. aureus | Yes | Pos (2.0) | Yes | 3 | Pos (1.8) | – | Pos (1.9) | – | Yes |
708 | S. aureus | Yes | Pos (3.4) | Yes | 6 | – | – | – | Pos (1.6) | Yes |
709 | S. aureus | Yes | Pos (2.5) | Yes | 6 | – | – | – | Pos (1.8) | Yes |
716 | S. aureus | Yes | Pos (4.8) | Yes | 6 | – | – | – | Neg (0.8) | No |
718 | S. aureus | Yes | Pos (0.9) | Yes | 6 | – | Pos (1.7) | Pos (2.8) | Pos (2.6) | Yes |