Benefits of biphasic calcium phosphate hybrid scaffold-driven osteogenic differentiation of mesenchymal stem cells through upregulated leptin receptor expression

Table 1 Microarray analyses of the top 12 higher and lower gene expressions of MSCs cultured in BCP hybrid scaffolds

Gene symbol	Entrez Gene	RefSeq transcript ID	BCP hybrid scaffold/HA hybrid scaffold fold changes
(a) Higher
LEPR	3953	NM_001003679 /// NM_001003680 /// NM_002303	4.25
MAFB	9935	NM_005461	2.99
IFI16	3428	NM_005531	2.81
FLJ10159	55084	NM_018013	2.35
MMP13	4322	NM_002427	2.27
COL21A1	81578	NM_030820	2.09
EIF4A1	1973	NM_001416	2.02
SEPP1	6414	NM_005410	1.95
APOE	348	NM_000041	1.94
RUNX2	860	NM_001015051 /// NM_001024630 /// NM_004348	1.94
PTGFR	5737	NM_000959	1.93
OLFML2B	25903	NM_015441	1.89
(b) Lower
INHBA	3624	NM_002192	0.50
WSB1	26118	NM_015626 /// NM_134264 /// NM_134265	0.49
GOLGA8A	23015	NM_015003	0.48
STMN2	11075	NM_007029	0.48
RIS1	25907	NM_015444	0.48
PPAP2B	8613	NM_003713 /// NM_177414	0.47
PWP1	11137	NM_007062	0.46
IQGAP1	8826	NM_003870	0.43
COMP	1311	NM_000095	0.41
RGC32	28984	NM_014059	0.38
STC1	6781	NM_003155	0.36
PGK1	5230	NM_000291	0.33

ISSN: 1749-799X