Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model

Table 7 Semi-quantitative histopathological analysis of the inflammatory reaction (results)

Time period	Group		Polymorphonuclear cells	Lymphocytes	Plasma cells	Macrophages	Giant cells/osteoclasts	Fibrin	Necrosis	Osteolysis	Neovessels
6 months	Agili-C	Mean	0.0	0.6	0.0	1.3	1.0	0.9	0.0	0.0	1.6
	Agili-C	SD	0.0	0.5	0.0	0.5	0.0	0.8	0.0	0.0	0.5
	Empty defect control	Mean	0.0	0.0	0.0	0.3	1.0	1.0	0.0	0.0	1.7
	Empty defect control	SD	0.0	0.0	0.0	0.5	0.0	0.8	0.0	0.0	0.5
12 months	Agili-C	Mean	0.0	0.3	0.0	0.7	1.1	0.1	0.0	0.3	0.0
	Agili-C	SD	0.0	0.7	0.0	0.9	0.3	0.3	0.0	0.7	0.0
	Empty defect control	Mean	0.0	0.3	0.0	0.7	1.3	0.3	0.0	0.0	1.0
	Empty defect control	SD	0.0	0.5	0.0	0.5	0.5	0.5	0.0	0.0	0.8

Grading scale: 0: absence, 1: slight, 2: moderate, 3: marked, 4: severe SD: standard deviation

ISSN: 1749-799X