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Table 1 Combined cartilage and bone repair score evaluation (from ICRS II-2010 and O’Driscoll et al.)

From: Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model

Nature of predominant tissue Structural characteristics Freedom from cellular changes of degeneration Freedom from degenerative changes in adjacent cartilage Immunohistochemistry labeling Overall assessment
Tissue morphology (including use of polarized light) Safranin-O staining of the matrix Surface regularity Structural integrity Thickness Bonding to the adjacent cartilage Basal integration Formation of a tidemark Subchondral bone abnormalities/marrow fibrosis Cancellous bone regeneration Abnormal calcification/ossification (cartilage tissue) Hypocellularity Chondrocyte clustering
Fibrous tissue or bone : 0 None: 0 Severe disruption, including fibrillation: 0 Severe disintegration: 0 0–50 % of normal cartilage: 0 Not bonded: 0 No basal integration: 0 Absence of visible interface: 0 Irregular subchondral plate, fracture, sclerosis, intense remodeling: 0 Slight: 1 No ectopic change: 0 Severe hypocellularity: 0 25–100 % of the cells: 0 Severe hypocellularity, poor or no staining: 0 -: No labeling Fibrous tissue: 0
Incompletely differentiated mesenchyme: 2 Slight: 1 Fissures 25–100 % of the thickness : 1 Slight disruption, including cysts: 1 50–100 % of normal cartilage: 1 Bonded at one end, or partially at both ends: 1 Partial integration: 2 Slight to moderate calcification front/tidemark: 2 Absence of abnormality: 3 Moderate (with residual fibrous tissue/cyst): 2 Presence of changes: 3 Moderate hypocellularity: 1 <25 % of the cells: 1 Mild or moderate hypocellularity, slight staining: 1 1: Slight labeling Fibrocartilage tissue: 2
Hyaline articular cartilage: 4 Moderate: 2 Superficial horizontal lamination : 2 Normal: 2 100 % of normal adjacent cartilage: 2 Bonded at both ends of graft : 2 Full integration: 4 A single tidemark (signs of maturation): 3 / Marked (limited residual fibrocartilage tissue): 3 / Slight hypocellularity: 2 No clusters: 2 Normal cellularity, mild clusters, moderate staining: 2 2: Moderate labeling Articular and hyaline cartilage tissue: 4
/ Normal or nearly normal: 3 Smooth and intact: 3 / / / / / / Complete: 4 / Normal cellularity: 3 / Normal cellularity, no clusters, normal staining: 3 3: Marked labeling /