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Table 4 ICRS histological grading scale

From: A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells

Feature Score Animal no. 1 Animal no. 2
Control site Implanted site Control site Implanted site
Surface Smooth/continuous 3 0 3 3 3
Discontinuities/irregularity 0
Matrix Hyaline 3 0 1 1 2
Mixture; hyaline/fibrocartilage 2
Fibrocartilage 1
Fibrous tissue 0
Cell distribution Columnar 3 0 0 0 2
Mixed/columnar clusters 2
Clusters 1
Individual cells/disorganized 0
Viability of cell population Predominantly viable 3 3 3 3 3
Partially viable 1
<10% viable 0
Subchondral bone Normal 3 1 2 0 2
Increased remodeling 2
Bone necrosis/granulation tissue 1
Detached/fracture/callus at base 0
Cartilage mineralization (calcified cartilage) Normal 3 0 3 3 3
Abnormal/inappropriate location 0
Average (0–3) 0.67 2 1.67 2.5