Table 4 ICRS histological grading scale
Feature | Score | Animal no. 1 | Animal no. 2 | |||
|---|---|---|---|---|---|---|
Control site | Implanted site | Control site | Implanted site | |||
Surface | Smooth/continuous | 3 | 0 | 3 | 3 | 3 |
Discontinuities/irregularity | 0 | |||||
Matrix | Hyaline | 3 | 0 | 1 | 1 | 2 |
Mixture; hyaline/fibrocartilage | 2 | |||||
Fibrocartilage | 1 | |||||
Fibrous tissue | 0 | |||||
Cell distribution | Columnar | 3 | 0 | 0 | 0 | 2 |
Mixed/columnar clusters | 2 | |||||
Clusters | 1 | |||||
Individual cells/disorganized | 0 | |||||
Viability of cell population | Predominantly viable | 3 | 3 | 3 | 3 | 3 |
Partially viable | 1 | |||||
<10% viable | 0 | |||||
Subchondral bone | Normal | 3 | 1 | 2 | 0 | 2 |
Increased remodeling | 2 | |||||
Bone necrosis/granulation tissue | 1 | |||||
Detached/fracture/callus at base | 0 | |||||
Cartilage mineralization (calcified cartilage) | Normal | 3 | 0 | 3 | 3 | 3 |
Abnormal/inappropriate location | 0 | |||||
Average (0–3) | 0.67 | 2 | 1.67 | 2.5 | ||