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Table 3 Examples of calculation of MCID or CID in pain scores in patients with painful spine conditions

From: Determining the clinical importance of treatment benefits for interventions for painful orthopedic conditions

Reference (treatment)

Method

Categories in anchor

Definition of MCID or CID for improvement

MCID or CID a

Distribution-based approaches

Carreon 2013 (lumbar fusion surgery) [17]

MDC

N/A—no anchor used

MDC defines the MCID

1.16 pt—back pain, 1.36 pt—leg pain

Gum 2013 (lumbar fusion surgery) [18]

MDC

N/A—no anchor used

MDC defines the MCID

0.20 pt—back pain, 0.23 pt—leg pain

Anchor-based approaches

Gum 2013 (lumbar fusion surgery) [18]

ROC—health transition item on SF-36

Much worse, somewhat worse, about the same, somewhat better, and much better

Change in pain score for patients being “somewhat better” (MCID)

3.08 pt—back pain, 2.83 pt—leg pain

Change in pain score for patients being “much better” (CID)

5.32 pt—back pain, 4.98 pt—leg pain

Carreon 2010 (cervical spine fusion) [19]

ROC—Health transition item of SF-36

Much better, somewhat better, about the same, somewhat worse, much worse

Distinguish the “somewhat better” from the “about the same” patients (MCID)

2.5 pt—arm and neck pain

Copay 2008 (lumbar spine surgery) [20]

Anchor—satisfaction with results scale

Answers: definitively true, mostly true, don’t know, mostly false, or definitively false to the following five items: 1. “I can do the things I thought I would be able to do after surgery”; 2. “I was helped as much as I thought I would be by my surgery”; 3. “My pain was reduced as much as I expected it to be after surgery”; 4. “The benefits of my care outweighed the setbacks it caused me”; 5. “All things considered, I would have the surgery again for the same condition”

Patients classified as “satisfied” and “don’t know”

1.2 pt—back pain, 1.6 pt—leg pain

Solberg 2013 (lumbar discectomy) [21]

Anchor—global perceived scale of change

Completely recovered, much improved, slightly improved, no change, slightly worse, much worse, and worse than ever

Patient reporting to be “completely recovered” or “much better” (CID)

2.5 pt—back pain, 3.5 pt—leg pain

Parker 2013 (anterior cervical discectomy and fusion) [22]

ROC—NASS

1) The treatment met my expectations; 2) I did not improve as much as I had hoped, but I would undergo the same treatment for the same outcome; 3) I did not improve as much as I had hoped, and I would not undergo the same treatment for the same outcome; and 4) I am the same or worse than before treatment

Patients with choice 1 classified as responders; choices 2–4 are non-responders (CID)

4.0 pt—VAS neck pain, 4.0 pt—VAS arm pain

Combination: NASS anchor + MDCb

2.6 pt—VAS neck pain, 4.1 pt—VAS arm pain

  1. NASS North American Spine Society patient satisfaction scale, N/A not applicable.
  2. aAll MCID and CID data presented in this table are for the 0–10 NRS, except for Parker 2013 which uses a 0–10 mm VAS.
  3. bThe MDC approach defines the MCID value as the upper value of the 95% CI for the average change score seen in non-responders (defined based on the anchor).