Could high-concentration rifampicin kill rifampicin-resistant M. tuberculosis? Rifampicin MIC test in rifampicin-resistant isolates from patients with osteoarticular tuberculosis

Table 2 M. tuberculosis rpoB wild-type and mutant isolates analyzed using the rpoB probe array

Clinical isolates	Resistance phenotype	MIC (μg/ml)	Mutated codon(s)
1	L	32	WT
2	L	64	516 A → G
3	L	64	516 A → G
4	L	128	513 A → C
5	H	128	526 C → G
6	H	256	513 A → C
7	H	256	531 C → T
8	H	ND	531 C → T
9	H	ND	531 C → T
10	H	ND	531 C → T
11	H	ND	531 C → T
12	H	ND	531 C → T
13	H	ND	531 C → T
14	H	ND	531 C → T
15	H	ND	531 C → T
16	H	ND	531 C → G
17	H	ND	526 C → T
18	H	ND	516 A → G
H37Rv	S	0.25	WT

S, susceptible to rifampicin; L, low-level resistance to rifampicin (resistant to 50 μg/ml rifampicin); H, high-level resistance to rifampicin (resistant to 250 μg/ml rifampicin); ND, not determined; WT, wild-type.

ISSN: 1749-799X