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Table 7 Commercially available bone graft substitutes: part 3

From: Bone regenerative medicine: classic options, novel strategies, and future directions

Company Commercially available product Composition Commercially available forms Claimed mechanisms of action Level of evidence FDA status
Medtronic Spinal & Biologics Progenix™ DBM Putty DBM in type1 bovine collagen and sodium alginate Ready to use injectable putty Osteoconduction Animal studies 510(k) cleared
Bioresorbable
Osteoinduction
Osteofil® DBM DBM in porcine gelatin Injectable paste and moldable strips Osteoconduction Animal studies 510(k) cleared
Bioresorbable Case reports
Osteoinduction
MTF/Synthes DBX® DBM in sodium hyaluronate carrier Paste, putty mix, and strip Osteoconduction Human studies 510(k) cleared
Bioresorbable Case reports
Osteoinduction Animal studies
NovaBone/ MTF NovaBone® Bioactive silicate Particulate and putty Osteoconduction Case reports 510(k) cleared
Bioresorbable Animal studies
Osteostimulation
Orthovita Vitoss® 100% β-TCP and 80% β-TCP/20% collagen Putty, strip, flow, morsels, and shapes Osteoconduction Published human studies 510(k) cleared
Bioresorbable Case reports
Animal studies
Osteotech Grafton® DBM combined with glycerol Formable putty, injectable gel, putty mixed with chips, flexible sheets, and matrix Osteoconduction Published human studies 510(k) cleared
Bioresorbable Case reports
Osteoinduction Animal studies
Graft on Plus® DBM combined with a starch carrier Paste Osteoconduction Case reports 510(k) cleared
Bioresorbable Animal studies
Osteoinduction
Regeneration Technologies BioSet™ DBM combined with natural gelatin carrier Injectable paste, injectable putty, strips, and blocks with cortical cancellous chips Osteoconduction Human studies 510(k) cleared
Bioresorbable Case reports
Osteoinduction Animal studies
Every lot tested in vivo for osteoinduction
Smith & Nephew VIAGRAF DBM combined with glycerol Putty, paste, gel, crunch, and flex Osteoconduction Animal studies 510(k) cleared
Bioresorbable
Osteoinduction
Stryker Biotech OP-1® Implant rhBMP-7 with type 1 bone collagen Lyophilized powder reconstituted to form wet sand Bioresorbable scaffold Human studies (level I data) HDE approval for long bone non-unions
Osteoinduction Case reports
Animal studies
OP-1® Putty rhBMP-7 with type 1 bone collagen Lyophilized powder reconstituted to form putty Bioresorbable scaffold Human studies (level I data) HDE approval for revision posterolateral fusion
Osteoinduction Case reports
Animal studies
Calstrux™ Tricalcium phosphate with carboxymethylcellulose Moldable putty Osteoconduction Animal studies 510(k) cleared
Bioresorbable
  1. Data were extracted based on the reports of FDA, American Academy of Orthopedic Surgeons, and information provided by the manufacturers.