Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague–Dawley rats

Table 3 Histomorphometrical scores detected at sacrifice

Groups	Thickness of articular cartilages
Groups	Femur	Tibia
Controls
Sham	570.69 ± 63.08	887.40 ± 75.03
OA	317.82 ± 77.79^a	354.80 ± 46.41^a
Diclofenac	472.56 ± 63.04^ab	486.90 ± 41.78^ab
Calcium gluconate treated
100 mg/kg	574.06 ± 55.77^b	689.43 ± 93.78^ab
50 mg/kg	471.21 ± 47.69^ab	482.43 ± 65.10^ab
25 mg/kg	335.92 ± 40.20^a	356.14 ± 52.71^a

After 84 days continuous oral treatment of calcium gluconate or subcutaneous treatment of diclofenac sodium in OA rats. Values are expressed as mean ± SD of eight rats, μm; OA, osteoarthritis. ^ap < 0.01 compared with sham control; ^bp < 0.01 compared with OA control.

ISSN: 1749-799X