Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague–Dawley rats

Table 1 Knee thicknesses after joint capsule exposure and maximum extensor angles detected at sacrifice

Groups	Knee thicknesses after joint capsule exposure at sacrifice (mm)	Maximum extensor angles (degrees)
Controls
Sham	7.72 ± 0.27	31.63 ± 3.46
OA	9.76 ± 0.60^a	66.88 ± 7.47^a
Diclofenac	9.16 ± 0.28^ac	47.13 ± 7.26^ac
Calcium gluconate-treated
100 mg/kg	8.96 ± 0.40^ac	39.50 ± 6.52^bc
50 mg/kg	9.16 ± 0.20^ac	47.38 ± 7.48^ac
25 mg/kg	9.52 ± 0.64^a	66.75 ± 10.33^a

After 84 days of continuous oral treatment of calcium gluconate or subcutaneous treatment of diclofenac sodium in OA rats. Values are expressed as mean ± SD of eight rats. OA, osteoarthritis; ^ap < 0.01 and ^bp < 0.05 compared with sham control; ^cp < 0.01 compared with OA control.

ISSN: 1749-799X