The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization

Table 1 Effect of growth factors on protein synthesis in wounded mineralized osteoblasts.

Treatment	Thymidine incorporation DPM × 10³/ug protein
con	37.6 ±2.9
IGF-1	42.3 ± 4.2
FGF-2	114.3 ± 11
TGFβ	65.2 ± 12
PDGF	39.8 ± 7.2
BMP-2	41.5 ± 5.6
PGE2	84.1 ± 23.1

Representative experiment showing the effects of IGF-1 (20 ng/ml), FGF-2 (2.0 ng/ml), TGFβ (2 ng/ml), PDGF (3 ng/ml), BMP-2 (100 ng), PGE₂ (2 μg/ml) on proliferation/mg protein of MC3T3-E1 osteoblasts after 24 hours of treatment (n = 4).

ISSN: 1749-799X