Cortical thickness and total bone area at the femoral neck measured by pQCT densitometry. Effects of alendronate (ALN), calcitriol (VitD), and combined alendronate and calcitriol treatments (ALN+VitD) on the pQCT densitometric parameters of cortical thickness and total bone area at the femoral neck in OVX rats after 12 weeks of treatment are shown. The data are presented as mean ± SD (n = 6 per group). ### P < 0.001 as compared with corresponding values in saline-treated OVX (unpaired t-test). *** P < 0.001 as compared with corresponding values in saline-treated OVX (Tukey's multiple comparison test). Total bone area was significantly decreased by OVX. Calcitriol single and the combined treatment induced a significant improvement in total bone area.