Figure 4

Cortical BMC and BMD at the femoral neck measured by pQCT densitometry. Effects of alendronate (ALN), calcitriol (VitD), and combined alendronate and calcitriol treatments (ALN+VitD) on the pQCT densitometric parameters of cortical BMC and BMD at the femoral neck in OVX rats after 12 weeks of treatment are shown. The data are presented as mean ± SD (n = 6 per group). ^### P < 0.001 as compared with corresponding values in saline-treated OVX (unpaired t-test). * P < 0.05, ** P < 0.01, *** P < 0.001 as compared with corresponding values in saline-treated OVX (Tukey's multiple comparison test). Cortical BMC was significantly lower in the saline-treated OVX than in the sham group. Cortical BMC in OVX rats was significantly improved by alendronate, calcitriol single treatment, and the combined treatment.