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Table 2 Identified differential Fecal metabolites between SONFH patients and AONFH patients

From: Non-traumatic osteonecrosis of the femoral head induced by steroid and alcohol exposure is associated with intestinal flora alterations and metabolomic profiles

Metabolites

Mean SONFH

Mean AONFH

VIP

P-valuea

FC

L-Lysine

1.11E + 08

1.63E + 08

1.73

0.047

1.47

Oxoglutaric acid

1.29E + 06

3.30E + 06

2.33

0.010

2.57

L-Serine

2.97E + 07

4.77E + 07

1.73

0.021

1.61

L-Glutamic acid

5.50E + 06

9.14E + 06

1.89

0.017

1.66

L-Valine

9.72E + 08

1.40E + 09

2.72

0.034

1.44

L-(-)-Methionine

1.44E + 08

2.00E + 08

1.41

0.017

1.39

D-Glutamine

4.06E + 07

7.08E + 07

2.25

0.014

1.75

Phosphoaspartate

2.70E + 05

1.24E + 06

1.83

0.049

4.59

(2R)-2,3-Dihydroxypropanoic acid

2.88E + 06

7.18E + 06

2.69

0.004

2.50

Phenylpyruvic acid

1.95E + 06

4.28E + 06

2.00

0.006

2.19

Xanthosine

3.18E + 05

1.68E + 06

3.55

0.001

5.29

4-Hydroxyphenylpyruvic acid

1.01E + 06

2.07E + 06

1.66

0.002

2.05

Gluconic acid

1.50E + 06

8.95E + 05

1.21

0.042

0.60

Phosphoric acid

9.49E + 06

4.21E + 06

2.84

0.024

0.44

ribulose 5-phosphate

6.31E + 05

2.55E + 05

1.35

0.040

0.40

phosphoglycolate

1.05E + 06

3.94E + 05

1.92

0.046

0.38

  1. VIP, variable importance in the projection; FC, fold change.aP-value was calculated by Student’s t-test