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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis

Fig. 7

FNDC5 overexpression improved HG-induced osteogenic differentiation in MC3T3-E1 cells. (A, B) The protein levels of ALP, RUNX2, and OCN. (C, D) Representative pictures and quantitative results of Alizarin red staining. (E) The results of the ALP activity test. *P < 0.05, **P < 0.01, ***P < 0.001 versus the con group. #P < , ##P < 0.01, ###P < 0.001 versus the HG group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X