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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis

Fig. 4

FNDC5/irisin treatment improved bone loss of diabetic mice. (A) Micro-CT analysis of the distal femur region and (B) the trabecular bone parameters (n = 3). (C) Serum concentrations of PINP and OCN (n = 6). (D, E) Representative Masson-stained images of the distal femur (scale: 500 μm, n = 3). (F, G) Protein levels of ALP, OCN, and RUNX2 (n = 6). **P < 0.01, ***P < 0.001 versus the CON group. #P < 0.05, ##P < 0.01, ###P < 0.001 versus the T1DM group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X