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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury

Fig. 7

UC-MSC-derived exosomes inhibit the inflammatory response of rat spinal cord tissue. (A) Effects of exosomes on spinal cord inflammation in rats by Western blot. (B-E) Representative graphs showing the relative levels of IL-1β (B), TNF-α (C), INOS (D) and IL-6 (E) in spinal cord tissue to β-actin. (F) Effects of exosomes on spinal cord anti-inflammation factors in rats by Western blot. (G-H) Representative graphs showing the relative levels of IL-10 (G) and IL-4 (H) in spinal cord tissue to β-actin. (I-J) Exosomes inhibited Iba-1 expression in spinal cord tissues. (K-N) Representative graphs showing the relative production of IL-6 (K), IL-1β (L), TNF-α (M), and INOS (N) by ELISA. (O) The immunohistochemistry analysis showed that exosomes downregulated TNF-α, IL-1β, and IL-6. Scale bar = 100 μm. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X