Fig. 2

Effects of miR-98-5p overexpression on IL‐1β‐caused inflammatory, apoptosis and ECM degradation in chondrocytes. A The expression of miR-98-5p was determined in CHON-001 cells transfected with miR-98-5p mimics or miR-NC after treatment of IL-1β. ***p < 0.001 indicates IL-1β + miR-98-5p mimics versus IL-1β + miR-NC; The inflammatory cytokines (B), cell viability (C), and caspase-3 activity (D) in CHON-001 cells transfected with miR-98-5p mimics or miR-NC after treatment of IL-1β. **p < 0.01 and ***p < 0.001 indicate IL-1β versus Control; #p < 0.05, ##p < 0.01, ###p < 0.001 indicates IL-1β + miR-98-5p mimics versus IL-1β + miR-NC; E The protein levels of Bcl-2, Bax, COL2A1, MMP-13 and β-catenin were detected in CHON-001 cells transfected with miR-98-5p mimics or miR-NC after treatment of IL-1β. **p < 0.01 and ***p < 0.001 indicate IL-1β versus Control; #p < 0.05 and ##p < 0.01 indicate IL-1β + miR-98-5p mimics versus IL-1β. All data are shown as means ± SD of three independent experiments