Fig. 8
From: Several first-line anti-hypertensives act on fibrosarcoma progression and PD1ab blockade therapy
Hydrochlorothiazide exerts its promoting effect through SLC12A3. (A–B) Data from the GEO were utilized to analyze the association between overall survival and SLC12A3 expression in sarcoma patients. (C) WB analysis of the SLC12A3 protein level in HT1080 after applying different concentrations of HCTZ. (D) The CCK8 assay detected the proliferation ability of HT1080 (shRNA#1 and shRNA#2) when adding HCTZ. (E–G) The xenograft growth assay indicated the tumor mass (F) and weight (G) of the HT1080 tumor (shRNA#1 and shRNA#2) when treated with HCTZ