Fig. 1
From: Several first-line anti-hypertensives act on fibrosarcoma progression and PD1ab blockade therapy
Verapamil showed enhanced effects on fibrosarcoma and tumor immune responses to PD1ab. A CCK8 experiment was used to detect the proliferation ability of MCA-205 after verapamil treatment. B Elisa kit was used to detect the VEGF production after verapamil treatment. C A double therapy (verapamil and PD1ab) or monotherapies were used for curing MCA-205 neoplasms on mice. D–F Tumor mass (D) and weight (E) from MCA-205-neoplasm mice (n = 10) were demonstrated. F Survival of mice (n = 10) was monitored biweekly after treatment. G–H The level of CD8+ T cells infiltration after treatment. Scale bars, 20 μm