Table 1 Characteristics of the included studies in the meta-analysis

Chen [23]

Rat

Female

NA

略 NA

8/8

Ovariectomy

Two weeks after OVX procedures; intragastric administration of 0.2 μM RES once;about 10 weeks

Bmd

Jing Feng [25]

Rat

Female

280–350

3 3 months

8/8(low-dose)/8(middle)/8(high)

Ovariectomy

Orally administrated at the dosage of 5, 25and 45 mg/kg/d, respectively, 7 days after operation for 8 weeks

Bmd,BV/TV, Tb.Th,Tb.N, Tb.Sp, alp,oc

Omnia Ameen [21]

Rat

Male

350–400

18–20 months

10/10

Aging-dependent male osteoporosis

Receiving resveratrol; 20 mg/kg/day for 6 weeks

Balp

Wei Wan [34]

Rat

Female

250 ± 10

10–12 weeks

10/10(low-dose)/10(middle)/10(high)

Ovariectomy

Res dissolved in 5 ml of normal saline and administered at the dosage of 10, 20, and 40 mg/kg/d to rats intragastrically for 8 weeks

Bmd

Liwei Wei [36]

Rat

Female

NA

6 months

8/8

Ovariectomy

Two weeks after ovariectomy, rats in OVX and Res groups were received, respectively, Res solution at 10 mg/kg body weight by daily intraperitoneal injection or saline for 12 weeks

Bmd,BV/TV, Tb.Th,Tb.N, Tb.Sp, balp, pg, TRACP-5b, CTX-1

Alka Khera [28]

Rat

Female

NA

3 months

6/6

Ovariectomy

The diet was mixed with resveratrol (625 µg/Kg body weight/day) and administered orally to experimental animals as diet pellets for 4 weeks

Bmd

Zamai et al. [38]

Rat

Female

NA

4 months

10/10

Ovariectomy

The administration of Res (10 mg/Kg) and placebo was performed via gavage during all experiment period after ovariectomy surgery; 22 weeks

Tb.N,Tb.Sp, BV/TV

Qian Lin [29]

Rat

Female

254.91 ± 18.01

3 months

8/8

Ovariectomy

OVX rats with Res 5 mg, 15 mg, 45 mg × kgbw-1 × day-1, respectively, for 13 weeks

Bmd

Yan-Ling Feng [26]

Rat

Female

220 ± 19.27

3 months

10/10

Ovariectomy

RES solution (40 mg/kg body weight, once daily; 10 weeks

Bmd,BV/TV, Tb.Th,Tb.N, Tb.Sp

Elseweidy et al. [24]

Rat

Female

200–220

3 months

6/6

Ovariectomy

OVX rats that received 80 mg/kg/day of Res orally for 8 weeks (Res)

Bmd, CTX-1, alp

Yixuan Jiang [27]

Mice

Female

NA

8 weeks

4/4

Ovariectomy

RES (40 mg/kg body weight) was performed intraperitoneally once every day for 8 weeks

BV/TV,Tb.N, Tb.Sp, CTX-1

Liu et al. [17]

Rat

Female

220–250

NA

11/11

Ovariectomy

RES group treated with 0.7 mg/kg of body weight of resveratrol. Tested materials were given by gavage for 12 weeks after ovariectomy

Bmd

Haifeng Zhao [19]

Rat

Female

200–220

3–4 months

10/10(low-dose)/10(middle)/10(high)

Ovariectomy

Res(20, 40,,80 mg/kg/day) was orally administered, respectively, through a custom-made stomach tube for 12 weeks

Bmd,Tb.Th, Tb.N, Tb.Sp, alp

Lee et al. [15]

Rat

Male

NA

6 months

7/7

Ageing rats

20 mg/kg/day; 3 months

BV/TV,OC,alp, CTX-1

Tresguerres et al. [33]

Rat

Male

NA

22 months

10/10

Ageing rats

Treated with Res at dosages of 10 mg/kg per day; 10 weeks

BV/TV,Tb.Th, Tb.N,Tb.Sp, CTX-1, OC

Sehmisch et al. [32]

Rat

Female

220–260

3 months

11/11(low-dose)/11(high)

Ovariectomy

The rats received daily doses of 5 mg/kg bw for RES low and 50 mg/kg bw for RES high; 3 months

Bmd

Ye Zhang [39]

Rat

Female

NA

NA

8/8(low-dose)/8(middle)/8(high)

Ovariectomy

Given orally with RES (50, 100, and 200 mg/day); 12 weeks

Bmd,balp, opg, TRAP-5b, CTX-1, alp,BV/TV, Tb.Th, Tb.N, Tb.Sp

Yujin Zhang [40]

Rat

Female

220 ± 18

3 months

8/8(low-dose)/8(middle)/8(high)

Ovariectomy

RES-L, RES-M and RES-H treatment group were, respectively, given RES (dimethyl sulfoxide, DWSO), the concentration of DWSO in the solution was 0.5% of 5 mg/(kg.d), 15 mg/(kg.d) and 45 mg/(kg.d) by gavage; 12 weeks

Bmd,oc,alp, CTX-1

Wang(35)

Rat

Female

300

12 weeks

8/8(low-dose)/8(high)

Ovariectomy

Resveratrol(5 mg/kg/day)/ (45 mg/kg/day) was administered orally, respectively, to rats for 10 weeks

Bmd,BV/TV, Tb.Th,Tb.N, Tb.Sp, opg

Yuquan Shi[37]

Mice

Female

NA

8 weeks

8/8

Ovariectomy

The mice received treatment with Res (7 mg/kg) on the second day after OVX surgery; 6 weeks

BV/TV,Tb.Th, Tb.N,Tb.Sp, balp, TRAP-5b

Sakr et al. [31]

Rat

Male

300 ± 25

14 weeks

8/8

Orchiectomy

Res time-release pellets (50 mg, Cat. No. NX-999) were implanted subcutaneously (one pellet/animal) to release the whole concentration of Res over 90 days

Bmd,opg,TRAP-5b, OC, alp

Osturk et al. [30]

Rat

Female

200–250

3 months

12/12(low-dose)/12(high)

Ovariectomy

Res was administered by oral gavage (40 and 80 mg/kg/day) for ten weeks

Bmd, Alp, OC, BV/TV,Tb.Th, Tb.Sp

Zuozhong Liu [41]

Mice

Female

NA

8 weeks

6/6

Ovariectomy

The mice received treatment with Res (7 mg/kg) on the second day after OVX surgery; 6 weeks

BV/TV,Tb.Th, Tb.N, Tb.Sp

Basem [22]

Rat

Female

365 ± 10

12–14 weeks

10/10

Ovariectomy

45 µg/kg/day, orally by gavage; 16 weeks

Bmd,opg,TRAP-5b, OC, alp