Correlation between vascular endothelial growth factor A gene polymorphisms and tendon and ligament injury risk: a systematic review and meta-analysis

Table 7 Pooled estimates of the association of VEGFA rs699947, rs1570360, and rs2010963 polymorphisms with tendon injury risk in Europeans

Genetic model	Test of association	Tests for heterogeneity		Egger’s test
Genetic model	OR (95% CI)	P	P_h	I² (%)	P_E
VEGFA rs699947
A versus C	0.98 (0.88–1.10)	0.758	0.109	50.50	0.356
AA + AC versus CC	0.92 (0.86–0.98)	0.015	0.225	33.00	0.075
AA versus CC	0.95 (0.81–1.12)	0.534	0.112	50.00	0.059
AA versus AC+CC	0.99 (0.83–1.17)	0.877	0.377	3.1	0.022
AA+CC versus AC	1.01 (0.83–1.24)	0.910	0.010	73.7	0.787
VEGFA rs1570360
A versus G	0.95 (0.84–1.09)	0.467	0.186	40.5	0.133
AA+AG versus GG	1.01 (0.82–1.24)	0.953	0.085	59.5	0.555
AA versus GG	0.86 (0.61–1.21)	0.381	0.844	0	0.875
AA versus AG+GG	0.84 (0.59–1.19)	0.326	0.678	0	0.006
AA+GG versus AG	1.29(1.14–1.45)	0.001	0.388	0	Na
VEGFA rs2010963
C versus G	1.15 (1.00–1.32)	0.045	0.388	0	Na
CC+CG versus GG	1.03 (0.93–1.13)	0.583	0.351	4.4	0.877
CC versus GG	1.40 (1.00–1.94)	0.049	0.273	16.7	Na
CC versus CG+GG	1.12 (0.69–1.82)	0.642	0.094	57.6	0.568
CC+GG versus CG	1.01 (0.91–1.13)	0.799	0.702	0	0.544

rs699947: allele model: A versus C, dominant model: AA+AC versus CC, additive model: AA versus CC, recessive model: AA versus AC+CC, over-dominant model: AA+CC versus AC
rs1570360: allele model: A versus G, dominant model: AA+AG versus GG, additive model: AA versus GG, recessive model: AA versus AG+GG, over-dominant model: AA+GG versus AG
rs2010963: allele model: C versus G, dominant model: CC+CG versus GG, additive model: CC versus GG, recessive model: CC versus CG+GG, over-dominant model: CC+GG versus CG
Statistical significance values are shown in bold, NA: not available

ISSN: 1749-799X