Correlation between vascular endothelial growth factor A gene polymorphisms and tendon and ligament injury risk: a systematic review and meta-analysis

Table 6 Pooled estimates of association of VEGFA rs699947, rs1570360, and rs2010963 polymorphisms and the risk of tendon injury

Genetic model	Test of association	Tests for heterogeneity		Egger’s test
Genetic model	OR (95% CI)	P	P_h	I² (%)	P_E
VEGFA rs699947
A versus C	1.08 (0.88–1.33)	0.455	0.029	59.90	0.184
AA+AC versus CC	1.16 (0.74–1.80)	0.514	0.001	78.30	0.423
AA versus CC	1.13 (0.75–1.71)	0.550	0.048	55.30	0.232
AA versus AC+CC	1.03 (0.83–1.28)	0.792	0.706	0	0.189
AA+CC versus AC	0.90 (0.65–1.26)	0.556	0.005	69.90	0.330
VEGFA rs1570360
A versus G	0.95 (0.81–1.11)	0.511	0.431	0	0.943
AA+AG versus GG	0.96 (0.70–1.31)	0.791	0.088	54.1	0.905
AA versus GG	0.88 (0.63–1.25)	0.484	0.857	0	0.212
AA versus AG+GG	0.88 (0.63–1.22)	0.426	0.661	0	0.117
AA+GG versus AG	1.53 (0.90–2.61)	0.115	0.001	84.4	0.520
VEGFA rs2010963
C versus G	1.07 (0.92–1.25)	0.364	0.163	41.5	0.997
CC+CG versus GG	1.07 (0.87–1.32)	0.523	0.502	0	0.555
CC versus GG	1.16 (0.83–1.62)	0.393	0.124	47.9	0.744
CC versus CG+GG	1.15 (0.84–1.57)	0.371	0.140	45.3	0.580
CC+GG versus CG	1.00 (0.81–1.23)	0.978	0.808	0	0.324

rs699947: allele model: A versus C, dominant model: AA + AC versus CC, additive model: AA versus CC, recessive model: AA versus AC + CC, over-dominant model: AA + CC versus AC
rs1570360: allele model: A versus G, dominant model: AA + AG versus GG, additive model: AA versus GG, recessive model: AA versus AG + GG, over-dominant model: AA + GG versus AG
rs2010963: allele model: C versus G, dominant model: CC + CG versus GG, additive model: CC versus GG, recessive model: CC versus CG + GG, over-dominant model: CC + GG versus CG

ISSN: 1749-799X