Fig. 5

WMP reduces inflammation in CIA rats by inhibiting the TLR4/NF-κB signaling pathway and reduces cartilage invasion by decreasing MMPs. A indicates western blot of WMP-affected synovial membrane-associated protein expression in CIA rats. B–I shows the levels of TLR4, TRAF6, NF-κB, IκB-α, MMP-2, MMP-9, TIMP-1, and TIMP-2 protein expression in the synovial membrane of each group. Data are expressed as mean ± standard deviation (n = 3). (#) p < 0.05, (##) p < 0.01 and (###) p < 0.001 versus control. (*) p < 0.05, (**) p < 0.01 and (***) p < 0.001 versus CIA