Fig. 4

WMP significantly reduced joint inflammation in CIA rats. A indicates the arthritis index score of rats in each group. B and C display the spleen and thymus immunity index of CIA rats in each group. D indicates H&E staining (green arrow indicates synovial hyperplasia, yellow arrow indicates inflammatory infiltrate). E indicates safranin O/fast green staining (orange arrow indicates cartilage band erosion). F and G depict the expression of TNF-α and IL-6 in the serum of rats in each group. Data are expressed as mean ± standard deviation (n = 5). (#) p < 0.05, (##) p < 0.01 and (###) p < 0.001 versus control. (*) p < 0.05, (**) p < 0.01 and (***) p < 0.001 versus CIA