Fig. 3

WMP reduces RA-FLS inflammation by inhibiting the TLR4/NF-κB signaling pathway and decreases RA-FLS migration and invasion by inhibiting MMPs. A depicts the western blot illustrating the impact of WMP on the expression of RA-FLS proteins in each group. B–I depict the expression levels of TLR4, TRAF6, NF-κB, IκB-α, MMP-2, MMP-9, TIMP-1, and TIMP-2 proteins in each group of RA-FLS. Data are expressed as mean ± standard deviation (n = 3). (#) p < 0.05, (##) p < 0.01 and (###) p < 0.001 versus control. (*) p < 0.05, (**) p < 0.01 and (***) p < 0.001 versus LPS