Study | Combine | IA | IV | Transfusion criteria | Pneumatic tourniquet | Thromboprophylaxis | DVT screening method | |
---|---|---|---|---|---|---|---|---|
IA | IV | |||||||
Huang ZY | 1.5Ā g TXA 50Ā mL NS after implantation of the components | 1.5Ā g TXA before inflation of the tourniquet | Ā | 3Ā g TXA before inflation of the tourniquet | 7.0Ā g/dLā<āHBā<ā10Ā g/dLā+āsymptomatic anemia HBā<ā7.0Ā g/dL | Yes | LMWH | Doppler ultrasound |
Jain NP | 2Ā g TXA 30Ā mL NS 5Ā min before closure of arthrotomy | 15Ā mg/kg TXA 30Ā min before skin incision 10Ā mg/kg TXA 3 and 6Ā h after surgery | Ā | 15Ā mg/kg TXA 30Ā min before skin incision 10Ā mg/kg TXA 3 and 6Ā h after surgery | 7.0Ā g/dLā<āHBā<ā8.0Ā g/dLā+āsymptoms HBā<ā7.0Ā g/dL | No | Aspirin | Ultrasonographic + clinical symptom |
Lin SY | 1Ā g TXA after joint capsule closure | 1Ā g TXA 15Ā min before skin incision | 1Ā g TXA 20Ā mL NS after joint capsule closure | Ā | HBā<ā8.0Ā g/dL HBā<ā9.0Ā g/dL +symptoms | Yes | Rivaroxaban | Clinical symptom |
Nielsen CS | 3Ā g TXA 100Ā mL NS after closure of the capsule | 1Ā g TXA preoperative | Ā | 1Ā g of TXA | HBā<ā7.5Ā g/dL HBā<ā10Ā g/dL +symptoms postoperative Hb level was reduced >25% + symptoms | No | Rivaroxaban | NS |
Song EK | 1.5Ā g TXA 50Ā mL NS after wound close | 10Ā mg/kg 20Ā min before tourniquet application 10Ā mg/kg 3Ā h after the second dose | 1.5Ā g TXA 50Ā mL NS after wound closure | 10Ā mg/kg 20Ā min before tourniquet application 10Ā mg/kg 15Ā min before deflation of the tourniquet 10Ā mg/kg 3Ā h after the second dose | HBā<ā8Ā g/dL | Yes | LMWH | Clinical symptom + Doppler ultrasonography and CT angiography |