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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients

Fig. 4

Effects of EP agonists on CGRP and CGRP receptors in synovial cell culture. Real-time polymerase chain reaction analysis for a calcitonin gene-related peptide (CGRP), b receptor activity-modifying protein 1 (RAMP1), and c calcitonin receptor-like receptor (CLR) gene expression in synovial cell culture. Synovial cells were stimulated with 10 μM iloprost (EP1), butaprost (EP2), sulprostone (EP3), or CAY10598 (EP4) for 24 h prior to the extraction and analysis of total RNA. All data are presented as the mean ± standard error (n = 6). *p < 0.05 compared with the untreated control

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X