Table 5 Examples of various MRI techniques used in OA animal models
From: Animal models of osteoarthritis: classification, update, and measurement of outcomes
MRI technique | Animal model | OA subset studied |
|---|---|---|
T1-rho | Rabbit-ACLT | Cartilage degeneration [326] |
Rat-meniscectomy | Decrease in cartilage thickness and loss of cartilage [327] | |
Rat-ACLT | Loss of proteoglycans, collagens and hydration changes [328] | |
Canine-stifle model | Osteophytosis and synovial thickening [329] | |
Guinea pig model | Cartilage thickness to study age related OA [330] | |
Rabbit model | Proteoglycan loss, disruption of collagen network [239] | |
T2-mapping | Rabbit-antigen induced OA | Synovitis, macrophages [331] |
Goat knee-papain induced OA | Cartilage damage [332] | |
Guinea pigs-aging | Cysts, osteophytes, sclerosis, cartilage degeneration [333] | |
Rabbit-papain induced | Cartilage thickness, loss of proteoglycan [334] | |
Rabbit-medial meniscectomy | Collagen order [335] | |
dGEMRIC | Goat-osteochondral defect | Glycosaminoglycan content [336] |
2D spin echo and 3D gradient echo | Canine model | OA bone abnormalities, intraosseous cysts [337] |
Rabbit-ACLT | Articular cartilage degradation, osteophyte formation, subchondral bone changes [338] | |
Rabbit-ACLT and meniscectomy | Synovial effusion, meniscus and ACL lesions, and osteophytes [339] | |
Rat-ACLT | Cartilage volume/thickness [242] | |
Rat-meniscectomy | Cartilage degeneration, subchondral bone defects, and osteophytes [235] | |
Goat-osteochondral defect | Osteochondral repair and bone lesions [340] | |
Mouse (C57BL/6) | Articular synovial space, subchondral bone [317] | |
Sodium MRI | Porcine (intra-articular injection (IL-1beta) | Proteoglycan content [341] |
Magnetization transfer | Rat model (antigen induced) | Macrophage infiltration, changes in water content [342] |
Goat knee-papain | Collagen concentration, proteoglycan depletion [332] | |
Rabbit-medial meniscectomy | Collagen framework, proteoglycan loss [239] |