From: Bone regenerative medicine: classic options, novel strategies, and future directions
Reference | Model of defect | Graft options | Model of study | Effects |
---|---|---|---|---|
Emami et al. [50] | Radial bone defect | Iliac crest autograft and bone marrow plus the autograft | Experimental study in15 rabbits | Bone marrow plus the autograft caused high tolerance to maximum load and bending stiffness |
Keskin et al. [11] | Ulnar bone defect | Autograft, bovine xenograft, and xenograft-autogenous bone marrow | Experimental study in 80 rabbits | Xenograft achieved the worst results. Combination of xenograft with autogenous bone marrow led to promising outcome |
Pereira-Junior et al. [33] | Radial bone defect | Cancellous bone autograft vs. granular polyurethanes containing castor oil | Experimental study in 20 rabbits | Autograft showed higher and faster bone regeneration than castor oil-based polyurethane containing biocompatible and osteointegrative properties |
Bigham et al. [3] | Radial bone defect | Fresh autogenous cortical bone vs. xenogenic bovine DBM | Experimental study in 20 rabbits | Fast healing without complications with xenogenic bovine DBM similar to autograft, but autograft group was superior to DBM only radiographically |
Bigham et al. [51] | Radial bone defect | Xenogenic bovine DBM vs. xenogenic bovine fetal growth plate | Experimental study in 20 rabbits | With both grafting groups, healing was faster, despite the fetal growth plate which was radiographically superior to DBM |
Shafiei et al. [14] | Radial bone defect | Fresh cortical autograft vs. fresh cortical allograft | Experimental study in 20 rabbits | Autograft was radiographically but not biomechanically and histopathologically superior to allograft |
Athanasiou et al. [12] | Femoral condyle defect | Autogenous, allograft-DBM, bovine cancellous bone xenograft and calcium phosphate hydroxyapatite and calcium phosphate substitutes | Experimental study in 90 rabbits | The best results obtained with the use of autograft, followed by bovine xenografts, allograft, and ultimately, the other substitutes had similar results |
Bansal et al. [4] | Tibial plateau fracture | Bovine cancellous xenograft | Clinical study, 19 patients | Obtained promising outcome, reduced operative time and bleeding good effects on bone healing |
Putzier et al. [20] | Lumbar segmental spondylodesis | Autogenous vs. allogenic iliac crest cancellous bone graft | Clinical study, 40 patients | Both grafts attained equivalent fusion rate without implant complications and accordingly similar clinical outcome |
Keles et al. [52] | Intraosseous periodontal defect | Combined autogenous cortical bone (ACB) and guided tissue regeneration (GTR) vs. ACB alone | Clinical study, 12 patients | Both the two groups resulted in improvement in clinical and radiological characteristics |
Thuaksuban et al. [63] | Alveolar cleft defect | Autogenous bone alone vs. autogenous bone with deproteinized bovine bone (DBB) | Clinical study, 30 patients | Duration of hospital stay, the average operation time, intraoperative blood loss, and post-operative pain were less; recovery was faster in patients receiving DBB with autogenous cancellous bone graft |
Faldini et al. [53] | Aseptic forearm non-union | Bone allograft with plate | Clinical study, 14 patients | High forearm alignment rate and improved forearm function led to bone healing |
Scaglione et al. [6] | Long bone non-union | Autologous concentrated bone marrow-derived cells combined with dried bone allograft (DBM) | Clinical study, 19 patients | Complete healing in 15 patients (78.9%) |