Table 2 Overview on comparative clinical trials of kyphoplasty
Author | Year | Design | Level of evidence | Control Group | Control n (levels) | Kyphoplasty n (levels) | Follow-up | Outcome |
|---|---|---|---|---|---|---|---|---|
Weisskopf et al. [54] | 2003 | Retrospective | IIIb | non-surgical | 20 (35) | 22 (37) | 10 days | Improvement in VAS (p < 0.001) Reduced days in hospital (p < 0.01) |
Fourney et al. [55] | 2003 | Retrrospective | IIIb | vertebroplasty | 34 (65) | 15 (32) | 4,5 months | No significant differences in VAS and ODI Improvement of kyphosis with kyphoplasty (p < 0.01) |
Komp et al. [56] | 2004 | Prospective | IIb | non-surgical | 19(19) | 21(21) | 6 months | Improvement of VAS and ODI with kyophoplasty (p < 0.01) |
Kasperk et al [57] | 2005 | Prospective | IIb | non-surgical | 20 (33) | 40 (72) | 12 months | Improvement of VAS (p < 0.01) and improvement of kyphosis (p < 0.001) with kyphoplasty |
Grohs et al. [58] | 2005 | Prospective | IIb | vertebroplasty | 23 (29) | 28 (35) | 24 months | No significant difference in ODI, but improvement of VAS with kyphoplasty (p < 0.05). No significant improvement of kyphosis |
Masala et al. [59] | 2005 | Retrospective | IIIb | vertebroplasty | 26 (33) | 7 (7) | 6 months | No significant difference in VAS. |
Pflugmacher et al [30] | 2005 | Prospective | IIb | vertebroplasty | 20 (32) | 22 (35) | 12 months | No significant difference in VAS and ODI. Improvement of kyphosis with kyphoplasty (p < 0.05) |
De Negri et al. [60] | 2007 | Prospective | IIb | vertebroplasty | 10 (18) | 11 (15) | 6 months | No significant difference in VAS and ODI. |
Zhou et al. [61] | 2008 | Prospective | IIIb | vertebroplasty | 42 | 56 | 12 months | No significant differences in VAS, operation time and blood loss. Improved vertebral height restoration with kyphoplasty (p < 0.01). |
Wardlaw et al. [13] | 2009 | Randomised | Ib | non-surgical | 149 | 151 | 12 months | Significant improvement in EQ-5D (p < 0.05), RMDQ (p < 0.001) VAS (p < 0.0001). |
Schmelzer-Schmied et al. [51] | 2009 | Prospective | IIb | non-surgical | 20 | 20 | 12 months | Significant greater improvement of VAS (p < 0.05) with kyphoplasty, which was lost after 3 months, and vertebral height preservation after 12 months (p < 0.01) |
Schofer et al. [62] | 2009 | Prospective | IIIb | vertebroplasty | 30 | 30 | 13 months | No significant differences in VAS and SF-36. Greater improvement of kyphotic angle with kyphoplasty (p < 0.001) |
Li X et al [63] | 2011 | Prospective | IIIb | vertebroplasty | 40 | 45 | 12 months | No significant differences in VAS and ODI. Significantly greater improvement of kyphotic angle with kyphoplasty (p < 0.01) |