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  1. COVID-19 was declared a global emergency in the first quarter of 2020. It is has resulted in and continues in over a million deaths worldwide and halted medical systems and particularly elective surgeries worl...

    Authors: Maciej J. K. Simon and William D. Regan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:161
  2. This study was designed to observe the expression of important hedgehog (Hh) signal factors in the bone tissue of rats with chronic fluorosis and cultured osteoblasts in order to investigate the role and signi...

    Authors: Chaonan Deng, Lin Xu, Ying Zhang, Lina Zhao, Yan Linghu and Yanni Yu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:160
  3. Computer-assisted three-dimensional (3D) planning is increasingly delegated to biomedical engineers. So far, the described fracture reduction approaches rely strongly on the performance of the users. The goal ...

    Authors: Christoph Zindel, Philipp Fürnstahl, Armando Hoch, Tobias Götschi, Andreas Schweizer, Ladislav Nagy and Simon Roner
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:159
  4. Adult developmental dysplasia of the hip is an untreated congenital hip dysplasia that results in adult hip pain. One of the usual and effective methods for the treatment of this condition is periacetabular os...

    Authors: Rui Luo, Guomin Li, Bo Li, Ruyin Hu and Yankun Li
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:157
  5. Accurate preoperative planning is an important step for accurate reconstruction in total hip arthroplasty (THA). Presently, preoperative planning is completed using either a two-dimensional (2D) template or th...

    Authors: Jiabang Huo, Guangxin Huang, Dong Han, Xinjie Wang, Yufan Bu, Ya Chen, Daozhang Cai and Chang Zhao
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:156
  6. On the 11th March 2020, the World Health Organization declared the COVID-19 outbreak a pandemic. Multiple new guidelines were proposed and existing models of social, domestic and hospital care altered. Most he...

    Authors: Alice Wignall, Vasileios Giannoudis, Chiranjit De, Andrea Jimenez, Simon Sturdee, Sohail Nisar, Hemant Pandit, Aashish Gulati and Jeya Palan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:155
  7. The coronavirus disease 2019 (COVID-19) pandemic has led to dramatic disruptions to orthopedic services. The purpose of this study is to quantify the reinstatement of elective orthopedic surgeries of our insti...

    Authors: Teng-fei Lou, Zun Ren, Zheng-hua Sun, Wei Wang and Cun-yi Fan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:154
  8. This study aims to analyze the clinical outcome of a new ultrasound-guided surgery for partial plantar fasciotomy performed with a needle for treatment of plantar fasciitis.

    Authors: A. Iborra, M. Villanueva, P. Sanz-Ruiz, Antonio Martin and Concepción Noriega
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:153
  9. Elderly patients with femoral neck fractures are at a higher risk of dislocation after hip arthroplasty procedures. In comparison with total hip arthroplasty (THA), bipolar hemiarthroplasty (HA) and dual-mobil...

    Authors: Hsuan-Hsiao Ma, Te-Feng Arthur Chou, Fu-Yuan Pai, Shang-Wen Tsai, Cheng-Fong Chen, Po-Kuei Wu and Wei-Ming Chen
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:152
  10. Spina bifida occulta (SBO) is one of the most common congenital spinal deformities. Although many studies have demonstrated the influence of lumbosacral dysplasia on low back pain (LBP) in young athletes, ther...

    Authors: Wenhao Li, Zhencheng Xiong, Chunke Dong, Jipeng Song, Liubo Zhang, Jun Zhou, Yanlei Wang, Ping Yi, Feng Yang, Xiangsheng Tang and Mingsheng Tan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:151
  11. We aimed to investigate the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow mesenchymal stem cells (BMSCs) following peroxidative damage and to explore the underly...

    Authors: Meiling Liu, Haifeng Ding, Hongzhi Wang, Manfeng Wang, Xiaowei Wu, Lu Gan, Luyang Cheng and Xianglu Li
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:150
  12. Knee osteoarthritis associated with extra-articular deformity (EAD) can confront the arthroplasty surgeons with challenges of bone resection and soft tissue balancing. The aim of this study was to describe a s...

    Authors: Jing-yang Sun, Guo-qiang Zhang, Jun-min Shen, Yin-qiao Du, Tie-jian Li, Zong-jie Geng, Yong-gang Zhou and Yan Wang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:149
  13. Popliteomeniscal fascicles (PMF) are considered the posterolateral meniscocapsular extensions which connect the lateral meniscus to the edge of the tibia. PMFs disruption leads to hypermobility of the lateral ...

    Authors: Alessio D’Addona, Andrea Izzo, Giovanni Di Vico, Donato Rosa and Nicola Maffulli
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:148
  14. Silymarin (SMN), a polyphenolic flavonoid, is involved in multiple bioactive functions including anti-inflammation. Pretreatment with SMN demonstrated chondroprotection against tumour necrosis factor-alpha (TN...

    Authors: Wen-Tien Wu, Yi-Ru Chen, Dai-Hua Lu, Fedor Svyatoslavovich Senatov, Kai-Chiang Yang and Chen-Chie Wang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:147
  15. A great deal of evidence has supported that growth differentiation factor 5 (GDF5) is associated with the occurrence of knee osteoarthritis (KOA), while their results are not consistent. In the present study, ...

    Authors: Bin Jia, Yaping Jiang, Yingxing Xu, Yingzhen Wang and Tao Li
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:146
  16. Muscle strength around the hip after total hip arthroplasty (THA) is crucial for preventing dislocation and limping. This study aimed to assess and compare muscle volume and degeneration after THA using the po...

    Authors: Taku Ukai, Goro Ebihara, Haruka Omura and Masahiko Watanabe
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:145
  17. The purpose of this study was to investigate the role of synovial fluid interleukin (IL)-1β in diagnosing chronic periprosthetic joint infection (PJI) and to identify the optimal threshold of synovial fluid IL...

    Authors: Hai Wang, Leilei Qin, Jiawei Wang and Wei Huang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:144
  18. Osteoarthritis (OA) is the most common joint disorder in the USA, and knee OA has the highest prevalence. Inflammation and decrease in vascularization are key factors in the degeneration of articular cartilage...

    Authors: Ashim Gupta, Nicola Maffulli, Hugo C. Rodriguez, Cassidy E. Lee, Howard J. Levy and Saadiq F. El-Amin III
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:143
  19. Leg length inequalities (LLI) are a common condition that can be associated with detrimental effects like low back pain and osteoarthritis. Inertial measurement units (IMUs) offer the chance to analyze daily a...

    Authors: Hannah Lena Siebers, Jörg Eschweiler, Valentin M. Quack, Markus Tingart and Marcel Betsch
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:142
  20. Half of osteonecrosis of the femoral head (ONFH) patients suffer femoral head collapse at initial diagnosis, and more than half are bilaterally affected. This study developed a percutaneous autologous impactio...

    Authors: Yutaka Kuroda, Manabu Nankaku, Yaichiro Okuzu, Toshiyuki Kawai, Koji Goto and Shuichi Matsuda
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:141
  21. To clarify contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty (THA) for addressing potential issues with cementless THA.

    Authors: Goro Motomura, Satoshi Hamai, Satoshi Ikemura, Masanori Fujii, Shinya Kawahara, Soichiro Yoshino and Yasuharu Nakashima
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:140
  22. To investigate osteointegration at the graft-bone interface and the prevention of osteoarthritis after anterior cruciate ligament (ACL) reconstruction using a silk-collagen scaffold with both ends modified by ...

    Authors: Fanggang Bi, Yangdi Chen, Junqi Liu, Yafei Wang, Danfeng Xu and Ke Tian
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:139
  23. Biomechanical comparison of wedge and biconcave deformity of different height restoration after augmentation of osteoporotic vertebral compression fractures was analyzed by three-dimensional finite element ana...

    Authors: Xiao-Hua Zuo, Yin-Bing Chen, Peng Xie, Wen-Dong Zhang, Xiang-Yun Xue, Qian-Xi Zhang, Ben Shan, Xiao-Bing Zhang, Hong-Guang Bao and Yan-Na Si
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:138
  24. Periprosthetic infection is a major cause of failure after segmental endoprosthetic reconstruction. The purpose of this study is to determine whether certain aspects of drain output affect infection risk, part...

    Authors: Jiayong Liu, Zhengfu Fan, Marc El Beaino, Valerae O. Lewis, Bryan S. Moon, Robert L. Satcher, Justin E. Bird, Spencer J. Frink and Patrick P. Lin
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:137
  25. The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment o...

    Authors: Ke Zhang, Zhuoying Li, Yunyang Lu, Linyi Xiang, Jiadong Sun and Hong Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:136
  26. To evaluates the efficacy and safety of rivaroxaban versus aspirin in prevention of venous thromboembolism (VTE) following total hip (THA) or knee arthroplasty (TKA) or hip fracture surgery.

    Authors: Bangsheng Hu, Lianxiang Jiang, Haixia Tang, Meizhu Hu, Jun Yu and Zeping Dai
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:135
  27. The aim of this study is to investigate the prognostic value of tibial component coverage (over-hang and under-hang) and the alignment of total knee arthroplasty (TKA) components 1 week after surgery. We selec...

    Authors: Changquan Liu, Guanglei Zhao, Kangming Chen, Jinyang Lyu, Jie Chen, Jingsheng Shi, Gangyong Huang, Feiyan Chen, Yibing Wei, Siqun Wang and Jun Xia
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:134
  28. Osteoarthritis (OA) is thought to be the most prevalent chronic joint disease, especially in Tibet of China. Here, we aimed to explore the integrative lncRNA and mRNA landscape between the OA patients of Tibet...

    Authors: Junming Luo, Xiaoqin Luo, Zhili Duan, Wenbin Bai, Xiaoming Che, Zhongshu Shan, Xiaona Li and Jinwu Peng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:133
  29. Osteoarthritis (OA) is a kind of systemic musculoskeletal disorder and a most important factor for causing disability and physical painfulness. Nevertheless, due to the fact that OA can be triggered by multipl...

    Authors: Chao Li, Li Li and Tian Lan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:132
  30. Three-dimensional preoperative planning was applied for the osteosynthesis of distal radius fractures. The objective of this study was to evaluate the reproducibility of three-dimensional preoperative planning...

    Authors: Yuichi Yoshii, Takeshi Ogawa, Atsuo Shigi, Kunihiro Oka, Tsuyoshi Murase and Tomoo Ishii
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:131
  31. Although integrated traditional Chinese medicine (TCM) has long been indicated to be effective in the treatment of sciatica and is widely used in the management of this condition, the mechanism by which integr...

    Authors: Yi Wang, Guogang Dai, Yan Xu, Ling Jiang, Zhibin Fu, Jiao Xia, Guogang Tian and Wanli Du
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:130
  32. Secreted frizzled-related protein 5 (SFRP5) is an endogenous inhibitor of Wnt5a (wingless-type family member 5a), which has been implicated in anti-inflammatory response. In this study, we aimed to investigate...

    Authors: Minghui Sun, Weijun Wang, Lingtian Min, Cheng Chen, Qing Li and Wenjie Weng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:129
  33. Whether vastus medialis obliquus atrophy exists in patients with patellofemoral pain syndrome and whether the amount of atrophy differs between the vastus medialis obliquus and vastus lateralis muscles remain ...

    Authors: Conglei Dong, Ming Li, Kuo Hao, Chao Zhao, Kang Piao, Wei Lin, Chongyi Fan, Yingzhen Niu and Wang Fei
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:128
  34. With the fourth largest metropolitan population density, motor vehicle drivers in Adelaide, South Australia, record the most number of motor vehicle insurance claims in Australia. Previous studies have shown a...

    Authors: John M. Abrahams, Christopher Sagar and Mark Rickman
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:127
  35. This study was conducted with the aim to compare the effect of posterior condyle offset (PCO) changes on knee joint function of patients following total knee replacement (TKR).

    Authors: Yimin Zhang, Jun Wang, Miao Zhang and Yun Xu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:126
  36. Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected ...

    Authors: Keisuke Oe, Feibi Zeng, Tomoaki Fukui, Munenobu Nogami, Takamichi Murakami, Tomoyuki Matsumoto, Ryosuke Kuroda and Takahiro Niikura
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:125
  37. Osteoarthritis (OA) is a multiple factorial disease with unidentified specific markers. The alternate method such as biochemical and genetic markers for the diagnosis of osteoarthritis is an undeniable need of...

    Authors: Yasmin Badshah, Maria Shabbir, Hunza Hayat, Zoha Fatima, Asad Burki, Sidra Khan and Shafiq ur Rehman
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:124
  38. To investigate the efficacy and safety of allograft and hydroxyapatite (HA) as substitutes for autograft in anterior cervical discectomy and fusion (ACDF).

    Authors: Changsheng Yang, Wentao Zhuo, Qingchu Li, Caiqiang Huang, Huibo Yan and Dadi Jin
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:123
  39. Pelvic bone fractures are one of the biggest challenges faced by trauma surgeons. Especially, the presence of bleeding and hemodynamic instability features is associated with high morbidity and mortality in pa...

    Authors: Myoung Jun Kim, Jae Gil Lee, Eun Hwa Kim and Seung Hwan Lee
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:122
  40. Although efficacy is related to many factors, the surgical approach is one of the most important intervention factors for complex ankle fractures. Ankle fractures involving the distal tibial plafond frequently...

    Authors: Tong Liu, Yiheng Cheng and Wenqing Qu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:120
  41. This study was performed to investigate the change in the bony alignment of the foot after tendo-Achilles lengthening (TAL) and the factors that affect these changes in patients with planovalgus foot deformity.

    Authors: Nak Tscheol Kim, Young Tae Lee, Moon Seok Park, Kyoung Min Lee, Oh Sang Kwon and Ki Hyuk Sung
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:118
  42. Despite tibial plateau fractures are often associated with meniscal tears, the association between meniscal tears and Schatzker classification remains unclear. The purpose of this study was to assess the frequ...

    Authors: Xiangtian Deng, Hongzhi Hu, Yuchuan Wang, Decheng Shao and Yingze Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:117
  43. Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1) was found to be elevated in rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLSs). However, whether HAN...

    Authors: Yuhua Su, Yajing Liu, Chao Ma, Chunxiao Guan, Xiufen Ma and Shan Meng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:116
  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sujin Kang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:115

    The original article was published in Journal of Orthopaedic Surgery and Research 2021 16:18

  45. There is still lack of data on deep vein thrombosis (DVT) following bone trauma. This study aimed to determine the epidemiologic characteristics of deep venous thrombosis (DVT) of lower extremities following tibi...

    Authors: Yanbin Zhu, Wei Chen, Junyong Li, Kuo Zhao, Junzhe Zhang, Hongyu Meng, Yingze Zhang and Qi Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:113
  46. Treatment of early-onset scoliosis (EOS) is still a challenge to patients, families, and surgeons. Previous studies have indicated that EOS patients are at high risk for complications following growth-friendly...

    Authors: Mohammad Zarei, Mehdi Tavakoli, Ehsan Ghadimi, Alireza Moharrami, Ali Nili, Ali Vafaei, Seyed Saeed Tamehri Zadeh and Soroush Baghdadi
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:112

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