Articles

Preliminary outcomes of allograft and hydroxyapatite as substitutes for autograft in anterior cervical discectomy and fusion with self-locking standalone cages

To investigate the efficacy and safety of allograft and hydroxyapatite (HA) as substitutes for autograft in anterior cervical discectomy and fusion (ACDF).

Authors: Changsheng Yang, Wentao Zhuo, Qingchu Li, Caiqiang Huang, Huibo Yan and Dadi Jin

A nomogram to predict arterial bleeding in patients with pelvic fractures after blunt trauma: a retrospective cohort study

Pelvic bone fractures are one of the biggest challenges faced by trauma surgeons. Especially, the presence of bleeding and hemodynamic instability features is associated with high morbidity and mortality in pa...

Authors: Myoung Jun Kim, Jae Gil Lee, Eun Hwa Kim and Seung Hwan Lee

A fibular notch approach for the treatment of ankle fractures involving the distal tibial plafond

Although efficacy is related to many factors, the surgical approach is one of the most important intervention factors for complex ankle fractures. Ankle fractures involving the distal tibial plafond frequently...

Authors: Tong Liu, Yiheng Cheng and Wenqing Qu

Preliminary proposal: a classification system for reconstruction with autologous femoral head after periacetabular tumors resection

Although researchers have adopted various methods for the resection and reconstruction of periacetabular tumors, the total incidence rate of complications remains high. Aiming for preserving the acetabulum and...

Authors: Chunzhi Yi, Jiaqian Zheng, Ruoyu Li, Yun Lan, Mincong He, Jieqing Lai, Tianan Guan, Fengxiang Pang, Zongquan Mo, Peng Chen, Yue Li, Nannan Zhou, Xingfu Yang and Bin Fang

Arthroscopically assisted evaluation of frequency and patterns of meniscal tears in operative tibial plateau fractures: a retrospective study

Despite tibial plateau fractures are often associated with meniscal tears, the association between meniscal tears and Schatzker classification remains unclear. The purpose of this study was to assess the frequ...

Authors: Xiangtian Deng, Hongzhi Hu, Yuchuan Wang, Decheng Shao and Yingze Zhang

Mesenchymal stem cell-originated exosomal lncRNA HAND2-AS1 impairs rheumatoid arthritis fibroblast-like synoviocyte activation through miR-143-3p/TNFAIP3/NF-κB pathway

Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1) was found to be elevated in rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLSs). However, whether HAN...

Authors: Yuhua Su, Yajing Liu, Chao Ma, Chunxiao Guan, Xiufen Ma and Shan Meng

Correction to: Assessing responsiveness of the EQ-5D-3L, the Oxford Hip Score, and the Oxford Knee Score in the NHS patient-reported outcome measures

An amendment to this paper has been published and can be accessed via the original article.

Authors: Sujin Kang

Response to comments on: Comparison of suprapatellar versus infrapatellar approaches of intramedullary nailing for distal tibia fractures

Authors: Yao Lu, Gen Wang, Bin Hu, Cheng Ren, Liang Sun, Zhimeng Wang, Changjun He, Hanzhong Xue, Zhong Li, Kun Zhang, Teng Ma and Qian Wang

Incidence and locations of preoperative deep venous thrombosis (DVT) of lower extremity following tibial plateau fractures: a prospective cohort study

There is still lack of data on deep vein thrombosis (DVT) following bone trauma. This study aimed to determine the epidemiologic characteristics of deep venous thrombosis (DVT) of lower extremities following tibi...

Authors: Yanbin Zhu, Wei Chen, Junyong Li, Kuo Zhao, Junzhe Zhang, Hongyu Meng, Yingze Zhang and Qi Zhang

Complications of dual growing rod with all-pedicle screw instrumentation in the treatment of early-onset scoliosis

Treatment of early-onset scoliosis (EOS) is still a challenge to patients, families, and surgeons. Previous studies have indicated that EOS patients are at high risk for complications following growth-friendly...

Authors: Mohammad Zarei, Mehdi Tavakoli, Ehsan Ghadimi, Alireza Moharrami, Ali Nili, Ali Vafaei, Seyed Saeed Tamehri Zadeh and Soroush Baghdadi

Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials

We aimed to evaluate the safety and efficacy of intra-articular (IA) magnesium (Mg) for postoperative pain relief after arthroscopic knee surgery.

Authors: Lijun Shi, Haiyun Zhu, Jinhui Ma, Li-Li Shi, Fuqiang Gao and Wei Sun

Tips and tricks to achieve osteotomy healing and prevent refracture after ulnar shortening osteotomy

Parallel osteotomy is essential for favorable osteotomy reduction and healing and technically challenging during diaphyseal ulnar shortening osteotomy (USO). This study aimed to evaluate the advantages of guid...

Authors: Jong Woo Kang, Soo Min Cha, Sang-gyun Kim, In Cheul Choi, Dong Hun Suh and Jong Woong Park

Long-term survival and clinical outcomes of non-vascularized autologous and allogeneic fibular grafts are comparable for treating osteonecrosis of the femoral head

Osteonecrosis of the femoral head (ONFH) is a disabling disease, which often involves young patients. Recently, various hip-preserving surgeries were recommended to delay total hip arthroplasty (THA).

Authors: Ke Jie, Wenjun Feng, Feilong Li, Keliang Wu, Jinlun Chen, Guanming Zhou, Huiliang Zeng and Yirong Zeng

Release characteristics of enoxaparin sodium-loaded polymethylmethacrylate bone cement

This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement release system with different concentrations of enoxaparin sodium (ES) and to investigate the release characteristics of ES after loadi...

Authors: Hui Sun, Xinzhe Ma, Zhiyong Li, Jianning Liu, Wei Wang and Xiangbei Qi

Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies

This study aimed to determine the effects of denosumab treatment on the joint destruction of Japanese females with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibodies.

Authors: Yu Mori, Takuya Izumiyama, Hiroaki Kurishima, Masayuki Kamimura, Kazuyoshi Baba, Naoko Mori and Eiji Itoi

Early intravenous tranexamic acid intervention reduces post-traumatic hidden blood loss in elderly patients with intertrochanteric fracture: a randomized controlled trial

Elderly patients with intertrochanteric fractures exhibit post-traumatic hidden blood loss (HBL). This study aimed to evaluate the efficacy and safety of reducing post-traumatic HBL via early intravenous (IV) ...

Authors: Huixu Ma, Hairuo Wang, Xiaotao Long, Zexiang Xu, Xiaohua Chen, Mingjin Li, Tao He, Wei Wang, Lei Liu and Xi Liu

MiR-140-3p inhibits the cell viability and promotes apoptosis of synovial fibroblasts in rheumatoid arthritis through targeting sirtuin 3

Synovial fibroblasts (SFs) with the abnormal expressions of miRNAs are the key regulator in rheumatoid arthritis (RA). Low-expressed miR-140-3p was found in RA tissues. Therefore, we attempted to investigate t...

Authors: Beibei Zu, Lin Liu, Jingya Wang, Meirong Li and Junxia Yang

Mid-term results of bilateral synchronous total hip arthroplasty for bony ankylosis in patients with ankylosing spondylitis

Total hip arthroplasty (THA) for bony ankylosis is technically challenging in patients with ankylosing spondylitis (AS). This study aimed to determine the mid-term results of bilateral synchronous THA for bony...

Authors: Lei Han, Renfu Quan, Zhenle Pei, Guoping Cao, Yungen Hu and Jingjing Liu

Experience of clinical screening for COVID-19 among patients undergoing elective orthopedic surgeries: an alternative proposal

The coronavirus disease 2019 (COVID-19) pandemic is the largest global event in recent times, with millions of infected people and hundreds of thousands of deaths worldwide. Colombia has also been affected by ...

Authors: Edwarth Soler, Sammy Nicolás Farah, Valeria P. Bustos, Sofía Elizabeth Muñoz Medina, Jairo Fernando Gómez, Ernesto Martinez Lema and Carlos Álvarez Moreno

Correlation between weight-bearing asymmetry and bone mineral density in patients with bilateral knee osteoarthritis

Although unloading of the joint is related to reduction of the local bone mineral density (BMD), little attention had been paid to the relationship between loading asymmetry and side-to-side difference of BMD ...

Authors: Kohei Nishizawa, Kengo Harato, Yutaro Morishige, Shu Kobayashi, Yasuo Niki and Takeo Nagura

A precise navigation device for fixation of patella fractures with modified K-wire tension band:a comparative retrospective study

Traditionally, the technique of modified tension band wires (MTBW) has been the most commonly used surgical procedure. The purpose of this study is to design a precise navigation device that can obtain a stand...

Authors: Fuming Wang, Haolan Xiong, Xiaotao Long, Yang Li, Xiaohua Chen and Gang Wang

Drug resistance of pathogens causing nosocomial infection in orthopedics from 2012 to 2017: a 6-year retrospective study

Hospital-acquired infections (HAIs) are an emerging global problem that increases in-hospital mortality, length of stay, and cost. We performed a 6-year retrospective study to provide valuable insight into app...

Authors: Xiaowei Yang, Runsheng Guo, Banglin Xie, Qi Lai, Jiaxiang Xu, Niya Hu, Lijun Wan, Min Dai and Bin Zhang

Comparison of two different ways to apply a circular plaster cast for distal radius fractures: biomechanical study

Although conservative treatment with circular plaster cast is the most commonly used method in distal radius fractures, the best method to apply it remains unclear.

Authors: Alejandro Espejo-Reina, María T. Carrascal-Morillo and Alberto D. Delgado-Martínez

Risk factors for femoral fracture in lateral decubitus direct anterior approach total hip arthroplasty using conventional stems: a retrospective analysis

To provide guidelines for surgery and reduce the incidence of fracture, this study analyzed the relationship between femoral fracture and related factors in direct anterior approach (DAA) total hip arthroplast...

Authors: Guanjun Sun, Yi Yin, Yongjie Ye and Qingshan Li

An experimental study on stress-shielding effects of locked compression plates in fixing intact dog femur

In orthopedic application, stress-shielding effects of implant materials cause bone loss, which often induces porosis, delayed bone healing, and other complications. We aimed to compare the stress-shielding ef...

Authors: Xinwen Zhao, Wensen Jing, Zhe Yun, Xun Tong, Zhao Li, Jiajia Yu, Yaohui Zhang, Yabin Zhang, Zhixue Wang, Yanhua Wen, Heping Cai, Jun Wang, Baoan Ma and Haien Zhao

Letter to the editor: Modified Stoppa as an alternative surgical approach for fixation of anterior fracture acetabulum: a randomized control clinical trial

Authors: Ahmed A. Khalifa

Minimally invasive surgery total knee arthroplasty is less popular, but the prosthesis designed specifically for MIS provides good survival and PROMs with a minimum follow-up of 10 years

The concept of minimally invasive surgery (MIS) was introduced in total knee arthroplasty (TKA) in the late 1990s. The number of MIS TKAs has clearly decreased in recent years. An implant designed specifically...

Authors: Shinya Toyoda, Takao Kaneko, Yuta Mochizuki, Masaru Hada, Kazutaka Takada, Hiroyasu Ikegami and Yoshiro Musha

Infrapatellar versus suprapatellar approach for intramedullary nailing of the tibia: a systematic review and meta-analysis

Intramedullary nailing (IMN) is a conventional technique for the treatment of tibial shaft fractures. It has been suggested that the suprapatellar (SP) approach holds advantages over the traditional infrapatel...

Authors: Nikhil Ponugoti, Branavan Rudran, Amr Selim, Sam Nahas and Henry Magill

Experience with periprosthetic infection after limb salvage surgery for patients with osteosarcoma

The rate of postoperative infection developing is higher after limb salvage surgery (LSS) following sarcoma resection compared with conventional arthroplasty. The goal of this study is to summarize our experie...

Authors: Tiao Lin, Qinglin Jin, Xiaolin Mo, Zhiqiang Zhao, Xianbiao Xie, Changye Zou, Gang Huang, Junqiang Yin and Jingnan Shen

A cadaveric study of the location and morphology of the central patellar ridge for bone-patellar tendon-bone graft

The central ridge of the patella is the thickest area of patella and varies among patients. This cadaveric study identified the location and thickness of the bone at the central patella ridge for bone-patellar...

Authors: Thanathep Tanpowpong, Thun Itthipanichpong, Thanasil Huanmanop, Nonn Jaruthien and Nattapat Tangchitcharoen

Letter to the Editor: Comparison of suprapatellar versus infrapatellar approaches of intramedullary nailing for distal tibia fractures

Authors: Ke Lu, Rong-xun Qian and Yi Yin

Incidence and risk factors for deep venous thrombosis of lower extremity after surgical treatment of isolated patella fractures

Limited information exists on the incidence of postoperative deep venous thromboembolism (DVT) in patients with isolated patella fractures. The objective of this study was to investigate the postoperative inci...

Authors: Zhanchao Tan, Hongzhi Hu, Xiangtian Deng, Jian Zhu, Yanbin Zhu, Dandan Ye, Xiaodong Cheng and Yingze Zhang

A useful intraoperative technique for transiliac-transsacral screws: a point-to-point coaxial guide apparatus

The transiliac-transsacral screw placement is a clinical challenge for surgeons. This study explored a point-to-point coaxial guide apparatus assisting the transiliac-transsacral screw insertion and aimed to i...

Authors: Ze-hang Zheng, Fei Xu, Zheng-qiang Luo, Ye Ren, Tao Fu, Han-qing Xu and Bin-bin Liu

Biomechanical finite element analysis of vertebral column resection and posterior unilateral vertebral resection and reconstruction osteotomy

Regarding the repair of vertebral compression fractures, there is a lack of adequate biomechanical verification as to whether only half of the vertebral body and the upper and lower intervertebral discs affect...

Authors: Ye Han, Xiaodong Wang, Jincheng Wu, Hanpeng Xu, Zepei Zhang, Kepeng Li, Yang Song and Jun Miao

The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study

To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of c...

Authors: Yiqin Zhou, Haobo Li, Dong Xiang, Jiahua Shao, Qiwei Fu, Yaguang Han, Jun Zhu, Yi Chen and Qirong Qian

Analysis of the therapeutic effect and prognosis in 86 cases of rib fractures and atelectasis

The aim of the present study was to explore the therapeutic effect and prognosis in patients with rib fractures and atelectasis after thoracic trauma in order to provide a basis for clinical decision-making in...

Authors: Degang Yin, Jingang Lu, Jiansheng Wang, Biao Yan and Zhongshu Zheng

High expression of ABCG2 is associated with chemotherapy resistance of osteosarcoma

Previous studies showed overexpression of ABCG2 in a variety of tumor tissues, which could potentially indicate the probability of chemotherapy resistance. This study aimed to reveal the role of ABCG2 in the d...

Authors: Hao Shu, Bin Yuan, Yao Huang, Lei Wang, Bing He, Qi Sun and Luning Sun

Better clinical outcome of total knee arthroplasty for rheumatoid arthritis with perioperative glucocorticoids and disease-modifying anti-rheumatic drugs after an average of 11.4-year follow-up

Previous evidence suggested that perioperative anti-rheumatic therapy for patients receiving total knee arthroplasty (TKA) helped improve postoperative rehabilitation for rheumatoid arthritis (RA), yet long-te...

Authors: Yi Ren, Qi Yang, Tim Luo, Jin Lin, Jin Jin, Wenwei Qian, Xisheng Weng and Bin Feng

Patellar resurfacing versus nonresurfacing in total knee arthroplasty: an updated meta-analysis of randomized controlled trials

Whether resurface the patella or not in total knee arthroplasty (TKA) was controversial. In 2013, we conducted a meta-analysis of randomized controlled trials (RTCs). After that, plenty of studies have been ca...

Authors: Kai Chen, Xiaoyu Dai, Lidong Li, Zhigang Chen, Haidong Cui and Shujun Lv

Performance of age-adjusted D-dimer values for predicting DVT before the knee and hip arthroplasty

To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients.

Authors: Jian Xiang Wu, Jiang Hui Qing, Yao Yao, Dong Yang Chen and Qing Jiang

Analgesic effect of single-shot ropivacaine at different layers of the surgical site in primary total hip arthroplasty: a randomised, controlled, observer-blinded study

The aim of this study was to evaluate the efficacy of local infiltration anaesthesia (LIA) during primary total hip arthroplasty (THA) via a posterolateral approach under general anaesthesia and to compare the...

Authors: Qiang Xiao, Bing Xu, Haoyang Wang, Zhenyu Luo, Mingcheng Yuan, Zongke Zhou and Fuxing Pei

Outcome and experience of arthroscopic lateral retinacular release combined with lateral patelloplasty in the management of excessive lateral pressure syndrome

Only a few studies have described the effect of full arthroscopic surgery in treatment of excessive lateral pressure syndrome (ELPS). Therefore, the purpose of this study was to assess the clinical efficacy an...

Authors: Cheng-Liang Wang, Ji-Bin Chen and Te Li

In vivo performance of Al₂O₃-Ti bone implants in the rat femur

Alumina-titanium (Al₂O₃-Ti) biocomposites have been recently developed with improved mechanical properties for use in heavily loaded orthopedic sites. Their biological performance, however, has not been investiga...

Authors: Marjan Bahraminasab, Samaneh Arab, Manouchehr Safari, Athar Talebi, Fatemeh Kavakebian and Nesa Doostmohammadi

Locked compression plating versus retrograde intramedullary nailing in the treatment of periprosthetic supracondylar knee fractures: a systematic review and meta-analysis

Periprosthetic fractures of the distal femur above a total knee arthroplasty (TKA) have traditionally been managed by locking compression plating (LCP). This technique is technically demanding and is associate...

Authors: Henry Magill, Nikhil Ponugoti, Amr Selim and James Platt

Efficacy of additional corticosteroids to multimodal cocktail periarticular injection in total knee arthroplasty: a meta-analysis of randomized controlled trials

As the ultimate method for the treatment of osteoarthritis, total knee arthroplasty (TKA) has been widely used in the clinic. Local injection of multimodal cocktails, including corticosteroids, is commonly use...

Authors: Qi Li, Guo Mu, Xiangbo Liu and Milian Chen

Risk factors of postoperative delirium in the knee and hip replacement patients: a systematic review and meta-analysis

The risk factors of postoperative delirium (POD), a serious while preventable complication, developed by patients undergoing knee and replacement surgery are still under investigation. In this systematic revie...

Authors: Xiao Rong, Zi-chuan Ding, Hao-da Yu, Shun-Yu Yao and Zong-Ke Zhou

Risk factors for rapid progressive neurological deterioration in patients with cervical spondylotic myelopathy

The rapid progressive cervical spondylotic myelopathy (rp-CSM) which had a course of CSM less than 1 month and suffered rapidly progressive neurological deterioration had few reports. Therefore, it is importan...

Authors: Weiyang Zhong, Lin Wang, Tianji Huang and Xiaoji Luo

Effects of exogenous nerve growth factor on the expression of BMP-9 and VEGF in the healing of rabbit mandible fracture with local nerve injury

Mandibular fracture healing is a complex process involving nerves and growth factors. Nerve growth factor (NGF) not only facilitates the maintenance of sympathetic neurite growth but also stimulates other grow...

Authors: Sen Yang, Jiao Cheng, Cheng Man, Lian Jiang, Guogeng Long, Wenjun Zhao and Dexin Zheng

Unilateral percutaneous vertebroplasty for osteoporotic lumbar compression fractures: a comparative study between transverse process root-pedicle approach and conventional transpedicular approach

Percutaneous vertebroplasty (PVP) is a routine operation for the treatment of osteoporotic lumbar compression fractures (OLCFs). As is well known, unilateral puncture is a common method. However, with the conv...

Authors: Wenwu Zhang, Shenpeng Liu, Xianhua Liu, Xiang Li, Le Wang and Yong Wan

HSP22 (HSPB8) positively regulates PGF2α-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts

Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling ...

Authors: Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa and Haruhiko Tokuda