Articles

Recombinant TSG-6 protein inhibits the growth of capsule fibroblasts in frozen shoulder via suppressing the TGF-β/Smad2 signal pathway

The tumor necrosis factor-stimulated gene-6 (TSG-6) has been confirmed to inhibit inflammation. It is now generally accepted that local inflammatory stimulation around shoulder capsule causes proliferative fib...

Authors: Zhongfan Liu, Yongrong Pei, Hao Zeng, Yibo Yang, Meng Que, Yuhui Xiao, Jing Wang and Xiaojun Weng

The effect of preoperative hypoalbuminemia on complications after primary hip arthroplasty

To explore the risk factors of preoperative hypoalbuminemia and its’ effects on complications in the elderly with primary hip arthroplasty.

Authors: Yang Tan, Lingxiao Jiang, Hankun Liu, Zhengqi Pan, Hua Wang and Liaobin Chen

Epidemiology, classification, treatment, and mortality of adult femoral neck and basicervical fractures: an observational study of 40,049 fractures from the Swedish Fracture Register

Although femoral neck fractures (FNFs) are common in orthopedic departments, optimal treatment methods remain in dispute. There are few large nationwide studies, including basicervical FNFs (bFNFs), on epidemi...

Authors: Jonas Sundkvist, Anders Brüggeman, Arkan Sayed-Noor, Michael Möller, Olof Wolf and Sebastian Mukka

Development and validation of a nomogram for prediction of the risk of positive hidden blood loss in the perioperative period of single-level thoracolumbar burst fracture

This study aimed to develop and validate an individualized nomogram to predict the risk of positive hidden blood loss (HBL) in patients with single-level thoracolumbar burst fracture (TBF) during the periopera...

Authors: Haosheng Wang, Tingting Fan, Zhi-Ri Tang, Wenle Li, Linjing Liu and Qiang Lin

Analysis of risk factors for perioperative hidden blood loss in unilateral biportal endoscopic spine surgery: a retrospective multicenter study

Hidden blood loss (HBL) represents an important complication of unilateral biportal endoscopic (UBE) spine surgery. This study aimed to evaluate HBL and its possible risk factors among patients undergoing UBE ...

Authors: Haosheng Wang, Kai Wang, Bin Lv, Wenle Li, Tingting Fan, Jianwu Zhao, Mingyang Kang, Rongpeng Dong and Yang Qu

Does clozapine really affect bone mineral density? An experimental study

The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an expe...

Authors: Bahattin Kerem Aydin, Selim Safali, Memduha Aydin, Umran Egilmez, Hakan Cebeci, Murat Çelik and Ummuhan Abdulrezzak

Is laminoplasty or laminectomy the best strategy for C₃ segment in French-door laminoplasty? A systematic review and meta-analysis

To compare the clinical outcomes of C₃ laminectomy and C₃ laminoplasty at the C₃ segment during French-door laminoplasty.

Authors: Tiantian Chen, Xun Zhang, Fanchao Meng, Jinglong Yan, Gongping Xu and Wei Zhao

Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice

The pathogenesis of hematogenous orthopaedic implant-associated infections (HOIAI) remains largely unknown, with little understanding of the influence of the physis on bacterial seeding. Since the growth veloc...

Authors: John M. Thompson, Alyssa G. Ashbaugh, Yu Wang, Robert J. Miller, Julie E. Pickett, Daniel L. J. Thorek, Robert S. Sterling and Lloyd S. Miller

Correction to: Mini-transverse incision using a novel bush-hook versus conventional open incision for treatment of carpal tunnel syndrome: a prospective study

Authors: Tianxiao Ma, Dongyue Wang, Yuqing Hu, Xiaocui Zhao, Wei Wang and Lihua Song

Analysis of intercondylar notch size and shape in patients with cyclops syndrome after anterior cruciate ligament reconstruction

Cyclops lesion is the second most common cause of extension loss after anterior cruciate ligament reconstruction. This study focused on the correlation between the anatomy of the intercondylar notch and the in...

Authors: Krzysztof Ficek, Jolanta Rajca, Jerzy Cholewiński, Agnieszka Racut, Paweł Gwiazdoń, Krzysztof Przednowek and Grzegorz Hajduk

Comment on “Clinical outcome of femoral neck system versus cannulated compression screws for fixation of femoral neck fracture in younger patients”

Authors: Yunfeng Tang and Guangling Wang

Anthropometric measurements of non-arthritic knees in an Egyptian population: an MRI-based study

Knee anthropometric characteristics were evaluated for different ethnicities; however, data from North African populations are deficient. The primary aim was to investigate the Egyptian knees’ anthropometric c...

Authors: Mohammad Kamal Abdelnasser, Ahmed A. Khalifa, Micheal Bassem, Mohammed Anter Abdelhameed, Mahmoud Faisal Adam, Hatem M. Bakr and Yaser E. Khalifa

Trampoline-related fractures of the proximal tibia in children

Trampoline-related fractures of the proximal tibial metaphysis are common in children and have been linked to subsequent valgus deformity of the tibia. The purpose of this study was to investigate the characte...

Authors: Changhoon Jeong, Sang Uk Lee, Hyun Gyun Kim and Sun Young Joo

Obese people benefit from lumbar spinal stenosis surgery as much as people of normal weight

Lumbar spinal stenosis (LSS) is a common degenerative condition of the spine that causes back pain radiating to the lower extremity. Surgical treatment is indicated to treat progressive radical symptoms. Obesi...

Authors: Henni Myllykangas, Leena Ristolainen, Heikki Hurri, Jouni Lohikoski, Hannu Kautiainen, Ville Puisto, Heikki Österman and Mikko Manninen

Incidence and risk factors for decreased range of motion of the knee joint after surgery for closed tibial plateau fracture in adults

The aim of this study was to quantify the incidence of and identify independent risk factors for decreased range of motion (ROM) of the knee joint after surgery for closed tibial plateau fractures in adults.

Authors: Junyong Li, Junzhe Zhang, Kuo Zhao, Yanbin Zhu, Hongyu Meng, Zhucheng Jin, Dandan Ye, Wei Chen and Yingze Zhang

Association of patellofemoral morphology and alignment with the radiographic severity of patellofemoral osteoarthritis

Risk factors for the severity of patellofemoral osteoarthritis (PFOA) are poorly understood. This research aims to evaluate the association between patellofemoral joint (PFJ) morphology and alignment with the ...

Authors: Yike Dai, Heyong Yin, Chongyang Xu, Hongrui Zhang, Ai Guo and Naicheng Diao

Complex ruptures of the quadriceps tendon: a systematic review of surgical procedures and outcomes

Chronic ruptures, ruptures following total knee arthroplasty (TKA), and re-ruptures of the quadriceps tendon (QT) are rare. A systematic review of the current literature was conducted on their treatment and ou...

Authors: Francesco Oliva, Emanuela Marsilio, Filippo Migliorini and Nicola Maffulli

Multimodal Peri-articular Injection with Tranexamic Acid can reduce postoperative blood loss versus Intravenous Tranexamic Acid in Total Knee Arthroplasty: A Randomized Controlled Trial

Tranexamic acid (TXA) has shown significant reductions in blood loss and transfusion rates in total knee arthroplasty (TKA). However, the optimal administration route continues to be debated. The aim of this t...

Authors: Hui-ming Peng, Wei Wang, Jin Lin, Xi-sheng Weng, Wen-wei Qian and Wen-da Wang

Three-dimensional mapping of distal humerus fracture

Distal humerus fractures (DHFs) constitute one-third of elbow fractures approximately. In this study, we aim to define and analyze the fracture lines and morphological features of DHFs using mapping technique.

Authors: Chao Wang, Yong Zhu, Haitao Long, Zhangyuan Lin, Ruibo Zhao, Buhua Sun, Shushan Zhao and Liang Cheng

Nomogram for predicting reoperation following internal fixation of nondisplaced femoral neck fractures in elderly patients

We aimed to evaluate risk factors and develop a nomogram for reoperation after internal fixation of nondisplaced femoral neck fractures (FNFs) in elderly patients.

Authors: Jian Zhu, Hongzhi Hu, Xiangtian Deng, Yiran Zhang, Xiaodong Cheng, Zhanchao Tan, Yanbin Zhu and Yingze Zhang

Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis

Focal chondral defects of the knee are common. Several surgical techniques have been proposed for the management of chondral defects: microfractures (MFX), osteochondral autograft transplantation (OAT), autolo...

Authors: Filippo Migliorini, Jörg Eschweiler, Hanno Schenker, Alice Baroncini, Markus Tingart and Nicola Maffulli

Relationship between pain intensity, pain catastrophizing, and self-efficacy in patients with frozen shoulder: a cross-sectional study

Pain catastrophizing and self-efficacy are useful for predicting pain; these are associated with pain intensity and facilitate evaluation of psychological factors. However, it remains unclear whether the effec...

Authors: Junya Hirata, Minori Tomiyama, Yasuhiro Koike, Manabu Yoshimura and Keiko Inoue

A mouse model of ankle-subtalar joint complex instability induced post-traumatic osteoarthritis

Ankle-subtalar joint complex instability is not uncommonly presented in the clinic, but symptoms and signs similar to other conditions can easily lead to its misdiagnosis. Due to the lack of appropriate animal...

Authors: Peixin Liu, Kaiwen Chen, Shuo Wang, Chunzhuo Hua, Hongtao Zhang and Jia Yu

Lack of in-brace x-rays in compliant AIS patients wearing full-time TLSO braces associates with failure

In-brace correction and brace compliance with thoraco-lumbo-sacral orthotic (TLSO) braces are associated with successful treatment of adolescent idiopathic scoliosis (AIS). This paper compares patients who had...

Authors: Isabel Alvarez, Kiley Poppino, Lori Karol and Amy L. McIntosh

Increasing transforming growth factor-beta concentrations with age decrease apelin in the rat rotator cuff

The rotator cuff undergoes natural degeneration with age, leading to age-related rotator cuff tear; however, the precise mechanism remains unclear. Transforming growth factor-beta (TGF-β) concentrations rise w...

Authors: Ryo Tazawa, Kentaro Uchida, Tomonori Kenmoku, Mitsufumi Nakawaki, Kyoko Muneshige, Daisuke Ishii, Gen Inoue and Masashi Takaso

A novel classification for medial malleolar fracture based on the 3-D reconstruction CT

Fracture of the medial malleolus is one of the most frequent injuries treated surgically; however, the classification of the fracture has not attracted much attention and a good classification system is still ...

Authors: Fangke Hu, Guoyun Bu, Jun Liang, Haijing Huang and Jinquan He

Footprint measurement methods for the assessment and classification of foot types in subjects with Down syndrome: a systematic review

Musculoskeletal disorders, especially in the feet, are common in people with Down syndrome (DS). Evaluation of podiatric footprints is important to prevent and manage orthopedic symptoms. The reliability of a ...

Authors: Lourdes Gutiérrez-Vilahú and Myriam Guerra-Balic

Efficacy and cost-effectiveness of universal pre-operative iron studies in total hip and knee arthroplasty

The prevalence of anaemia in patients planned for total hip and knee arthroplasty is about 20%. Optimising pre-operative haemoglobin levels by iron supplementation has been shown to decrease transfusion rates,...

Authors: Viju Daniel Varghese, David Liu, Donald Ngo and Suzanne Edwards

Factors affecting the outcome of lower extremity osteomyelitis treated with microvascular free flaps: an analysis of 65 patients

Free flaps have been a useful modality in the management of lower extremity osteomyelitis particularly in limb salvage. This study aimed to determine the factors affecting the outcome of free flap reconstructi...

Authors: Duy Quang Thai, Yeon Kyo Jung, Hyung Min Hahn and Il Jae Lee

Return to work in patients with lumbar disc herniation undergoing fusion

Lumbar disc herniation (LDH) is a common problem. When surgical treatment is required, the intervention is typically decompression without fusion. Successful return-to-work (RTW) is a standard expectation with...

Authors: Lauren A. Protzer, Steven D. Glassman, Praveen V. Mummaneni, Mohamad Bydon, Erica F. Bisson, Mladen Djurasovic and Leah Y. Carreon

Effect of drugs on bone mineral density in postmenopausal osteoporosis: a Bayesian network meta-analysis

Osteoporosis affects mostly postmenopausal women, leading to deterioration of the microarchitectural bone structure and low bone mass, with an increased fracture risk with associated disability, morbidity and ...

Authors: Filippo Migliorini, Nicola Maffulli, Giorgia Colarossi, Jörg Eschweiler, Markus Tingart and Marcel Betsch

Application of the “telescopic rod” in a combined surgical technique for the treatment of congenital pseudarthrosis of the tibia in children

The current surgical treatment of choice is the combination surgical technique, involving tibial intramedullary fixation to maintain the mechanical axis and mechanical stability of tibial pseudarthrosis. In tr...

Authors: Yaoxi Liu, Ge Yang, Guanghui Zhu, Qian Tan, Jiangyan Wu, Kun Liu, Jin Tang and Haibo Mei

In reply to the letter to the editor regarding “Cemented versus uncemented hemiarthroplasty for femoral neck fractures in patients with neuromuscular diseases: a minimum of 2 years’ follow-up study”

Authors: Yuchuan Wang, Zhongzheng Wang, Siyu Tian, Zhanchao Tan, Yanbin Zhu, Wei Chen and Yingze Zhang

Single volar locking plating for the intra- and extra-articular distal radius fractures with dorsal metaphyseal comminution

Volar locking plating remains a popular method for the surgical management of distal radius fractures. Dorsal metaphyseal comminution (DMC) is a common fracture pattern which weakens the stability during fract...

Authors: Xue-yang Gui, Zhao-hui Cheng, Hong-fei Shi, Yi-xin Chen, Jin Xiong, Jun-fei Wang, Xu-sheng Qiu and Zi-tao Zhang

Reliability and validity of the novel self-reported spine functional scale (SSFS) in healthy participants

To develop the novel self-reported spine functional scale (SSFS) and conduct reliability and validity analysis, so that the public can better understand their own spine function in a more simple and scientific...

Authors: Wei Li, Jie Ding, Xiujuan Hao, Wenjun Jiang, Hongqiang Song, Yanming Zhang and Yan Tan

External fixation versus elastic stable intramedullary nailing in the treatment of open tibial shaft fractures in children

External fixator (EF) is a popular choice for open tibial fractures, but pin tract infection (PTI) and refracture are common complications. Elastic stable intramedullary nail (ESIN) has been reported in the tr...

Authors: Pan Hong, Saroj Rai, Xin Tang, Ruikang Liu and Jin Li

The biomechanical effect of preexisting different types of disc herniation in cervical hyperextension injury

Preexisting severe cervical spinal cord compression is a significant risk factor in cervical hyperextension injury, and the neurological function may deteriorate after a slight force to the forehead. There are...

Authors: Jian-jie Wang, Meng-lei Xu, Hui-zi Zeng, Liang-dong Zheng, Shi-jie Zhu, Chen Jin, Zhi-li Zeng, Li-ming Cheng and Rui Zhu

Failure load of the femoral insertion site of the anterior cruciate ligament in a porcine model: comparison of different portions and knee flexion angles

This study compared the failure load of the femoral insertion site of the anterior cruciate ligament between different portions and knee flexion angles.

Authors: Shohei Yamauchi, Kyohei Ishibashi, Eiji Sasaki, Shizuka Sasaki, Yuka Kimura and Yasuyuki Ishibashi

Iron accumulation deteriorated bone loss in estrogen-deficient rats

Postmenopausal osteoporosis is characterized by an imbalance of bone resorption exceeding bone formation, resulting in a net loss of bone mass. Whether a menopause-related excess of iron contributes to the dev...

Authors: Lu-lin Liu, Gong-wen Liu, Hui Liu, Kai Zhao and You-jia Xu

Intraarticular bone grafting in atlantoaxial facet joints via a posterior approach: nonstructural or structural—a minimum 24-month follow-up

To investigate the necessity of nonstructural or structural intraarticular bone grafting in atlantoaxial facet joints via a posterior approach and the influence by the presence of basilar invagination (BI).

Authors: Jun Zhu, Jian Wu, Keyu Luo, Zhong Wang, Huaijian Jin, Yufei Jin, Yingbo Wang, Mingyong Liu and Peng Liu

Comprehensive analysis of metabolism-related lncRNAs related to the progression and prognosis in osteosarcoma from TCGA

Osteosarcoma is one of the most common malignant neoplasms in children and adolescents. Studies have shown that metabolism-related pathways are vital for the development and metastasis of osteosarcoma. Long no...

Authors: Xingyin Chen, Zhengyun Ye, Pan Lou, Wei Liu and Ying Liu

Radiographic analysis of the sacral-2-alar screw trajectory

To explore the feasibility of sacral-2-alar (S2-alar) screw placement by measuring the length, diameter, and angle of the screw trajectory on computed tomography (CT).

Authors: Yulin Zhao, Baisheng Yuan, Yijun Han and Binglei Zhang

A comparative study of total knee arthroplasty outcome for stiff knee with or without sequential antirheumatic drug treatment

The aim of this study was to evaluate the influence of antirheumatic drug treatment on knee function of stiff knee patients after total knee arthroplasty (TKA).

Authors: Cheng-Qi Jia, Xiao-Rui Guan, Zhi-Lai Zhao, Ji-Ying Chen and Xiang Li

Efficacy of ultra-early rehabilitation on elbow function after Slongo’s external fixation for supracondylar humeral fractures in older children and adolescents

To evaluate the efficacy of ultra-early rehabilitation on elbow function after Slongo’s external fixation for supracondylar humeral fractures in older children and adolescents.

Authors: Man He, Qian Wang, Jingxin Zhao and Yu Wang

Nomogram to predict collapse-free survival after core decompression of nontraumatic osteonecrosis of the femoral head

Nontraumatic osteonecrosis of the femoral head (NONFH) is a devastating disease, and the risk factors associated with progression into collapse after core decompression (CD) remain poorly defined. Therefore, w...

Authors: En-Ze Zhao, Zun-Han Liu, Wei-Nan Zeng, Zi-Chuan Ding, Zhen-Yu Luo and Zong-Ke Zhou

Validation of the Spanish version of the Goodman score in total hip arthroplasty

Currently, patient-reported outcome measures (PROMs) are the standard instruments used to compare arthroplasty results. Goodman et al. recently published a well-constructed scale with excellent psychometric pr...

Authors: Julián Brañes, Maximiliano Barahona, Sebastián Carvajal, Rodrigo Wulf and Cristián Barrientos

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (...

Authors: Weikun Liu and Yanfu Wang

Letter to the Editor: Cemented versus uncemented hemiarthroplasty for femoral neck fractures in patients with neuromuscular diseases: a minimum of 2 years’ follow-up study

Authors: Wang Xing, Huang Qiang and Pei Fuxing

Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis: study protocol for a preliminary non-randomized, open-label, multi-center feasibility and safety study

Musculoskeletal conditions are highly prevalent, and knee OA is most common. Current treatment modalities have limitations and either fail to solve the underlying pathophysiology or are highly invasive. To add...

Authors: Ashim Gupta, Nicola Maffulli, Hugo C. Rodriguez, R. Justin Mistovich, Kristin Delfino, Craig Cady, Anne-Marie Fauser, Echo D. Cundiff, Marte A. Martinez and Anish G. Potty

Functional outcome and complication following THA through modified direct anterior approach correlated to cadaveric study: are there any differences in Asian hip?

Direct anterior approach (DAA) has several advantages including shorter length of hospital stay, faster recovery, and better functional outcome while this approach may cause damage to the lateral femoral cutan...

Authors: Ong-art Phruetthiphat, Vasin Sangthumprateep, Songpol Trakulngernthai, Noppadol Aegakkatajit, Thanainit Chotanaphuti and Malee Chanpoo