Articles

COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively

Recent studies indicate that, in addition to antibody production, lymphocyte responses to SARS-CoV-2 may play an important role in protective immunity to COVID-19 and a percentage of the general population may...

Authors: Marco S. Caicedo, Vianey Flores, Alicia Padilla, Samelko Lauryn, Joshua J. Jacobs and Nadim J. Hallab

Insufficient blood supply of fovea capitis femoris, a risk factor of femoral head osteonecrosis

A defective nutrient foramen in the fovea capitis femoris was hypothesized to reflect the blood circulation pattern of the femoral head, leading to insufficient blood supply and causing osteonecrosis of the fe...

Authors: Keyang Zhao, Fangfang Zhang, Kun Quan, Bin Zhu, Guangyi Li and Jiong Mei

Nuclear lamin A in rotator cuff tear margin tenocytes: an antiapoptotic and cell mechanostat factor

The network of intermediate filament proteins underlying the inner nuclear membrane forms the nuclear lamin. A- and B-type lamins are the major components of the nuclear lamina. Lamins function in many nuclear...

Authors: Stefano Gumina, Barbara Peruzzi, Martina Leopizzi, Natale Porta, Valeria Di Maio, Carlo Della Rocca and Vittorio Candela

Expression of miR-195 and its target gene Bcl-2 in human intervertebral disc degeneration and their effects on nucleus pulposus cell apoptosis

To investigate the expression of miR-195 and its target gene Bcl-2 in intervertebral disc degeneration (IVDD) and its effect on nucleus pulposus (NP) cell apoptosis.

Authors: Xue-Lin Lin, Zhao-Yun Zheng, Qing-Shan Zhang, Zhen Zhang and You-Zhi An

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment.

Authors: Cun Zhang, Tong Tong, De-chao Miao and Lin-feng Wang

Knockdown of long noncoding RNA HOTAIR inhibits osteoarthritis chondrocyte injury by miR-107/CXCL12 axis

Osteoarthritis (OA) is a joint disease characterized via destruction of cartilage. Chondrocyte damage is associated with cartilage destruction during OA. Long noncoding RNAs (lncRNAs) are implicated in the reg...

Authors: Jipeng Lu, Zhongxiong Wu and Ying Xiong

A novel retractor-assisted closed reduction combined with percutaneous pinning fixation for the treatment of elderly distal radius fractures: a retrospective cohort study

Percutaneous pinning fixation (PCP) has been used for the treatment of distal radius fractures for decades, especially in the elderly with fragile soft tissue. However, achieving and maintaining a sound anatom...

Authors: Bin Zhao, Wenqian Zhao, Isaac Assan, Zhenji Li and Rongxiu Bi

A comparison of thrombosis in total knee arthroplasty with and without a tourniquet: a meta-analysis of randomized controlled trials

Tourniquets are widely used in total knee arthroplasty (TKA), but the issue of their safety remains controversial. Previous studies have focused on TKA blood loss, duration of surgery, and hemostatic drugs. Th...

Authors: Jia Xie, Hao Yu, Fangyuan Wang, Juehua Jing and Jun Li

Treatment of posterolateral tibial plateau fractures with a rotational support plate and special pressurizer: technical note and retrospective case series

In tibial plateau fractures, the posterolateral segment of the tibia plateau is frequently affected and challenging to treat. Although there are many surgical approaches and fixation methods for the treatment ...

Authors: Yu-Feng Chen, Dong Ren, Lin-Dan Geng, Shuang-Quan Yao, Zhao-Hui Song, Liang Guang, Tian-Ci Wang and Peng-Cheng Wang

Preoperative risk factors for postoperative blood transfusion after hip fracture surgery: establishment of a nomogram

This study aimed to explore the preoperative risk factors related to blood transfusion after hip fracture operations and to establish a nomogram prediction model. The application of this model will likely redu...

Authors: Fu Cheng Bian, Xiao Kang Cheng and Yong Sheng An

Surgical treatment of proximal humeral fractures with the transosseous suture fixation

The surgical treatment of displaced proximal humeral fractures is commonly affected by implant-related complications. We evaluated the functional and radiographic results of transosseous suture fixation in a s...

Authors: J. Miquel, R. Martínez, F. Santana, P. Marimon and C. Torrens

Prevalence and risk factors of preoperative deep venous thrombosis in closed patella fracture: a prospective cohort study

The preoperative prevalence of deep venous thromboembolism (DVT) of patella fracture is not well established. The study aimed to investigate the preoperative prevalence, the associated risk factors, and the lo...

Authors: Zhanchao Tan, Hongzhi Hu, Zhongzheng Wang, Yuchuan Wang and Yingze Zhang

T-614 attenuates knee osteoarthritis via regulating Wnt/β-catenin signaling pathway

The aim of this study was to investigate the effect of Iguratimod (T-614) on rat knee osteoarthritis (KOA) and further to explore its underlying mechanism.

Authors: Shan Cong, Yan Meng, Lingrui Wang, Jiao Sun, Ta bu shi·Nu er xia ti and Li Luo

Epidemiology of proximal humerus fractures

Authors: Sandra Iglesias-Rodríguez, Diego Matías Domínguez-Prado, Alejandro García-Reza, Daniel Fernández-Fernández, Elena Pérez-Alfonso, Javier García-Piñeiro and Manuel Castro-Menéndez

Tranexamic acid given into wound reduces postoperative drainage, blood loss, and hospital stay in spinal surgeries: a meta-analysis

Although intravenous tranexamic acid administration (ivTXA) has prevailed in clinical antifibrinolytic treatment, whether it increases thromboembolic risks has remained controversial. As a potent alternative t...

Authors: Shangyi Hui, Yue Peng, Liyuan Tao, Shengru Wang, Yang Yang, You Du, Jianguo Zhang and Qianyu Zhuang

Comparison of denosumab and zoledronic acid for the treatment of solid tumors and multiple myeloma with bone metastasis: a systematic review and meta-analysis based on randomized controlled trials

To compare the efficacy and safety between denosumab and zoledronic acid for advanced cancer with bone metastasis.

Authors: Lianghai Jiang, Xianghua Cui, Haoning Ma and Xiangsheng Tang

LncRNA CASC19 accelerates chondrocytes apoptosis and proinflammatory cytokine production to exacerbate osteoarthritis development through regulating the miR-152-3p/DDX6 axis

Osteoarthritis (OA) is one kind of degenerative joint disease that happens in articular cartilage and other joint tissues. Long non-coding RNAs (lncRNAs) have been reported to serve as pivotal regulators in ma...

Authors: Chang Zhou, Tianda He and Liji Chen

Application of a targeted and quantificational foraminoplasty device in percutaneous transforaminal endoscopic discectomy for L5–S1 disc herniation: preliminary clinical outcomes

Percutaneous transforaminal endoscopic discectomy (PTED) is minimally invasive and has been widely used to treat patients with lumbar disc herniation (LDH) due to its safety and efficiency. However, due to the...

Authors: Jinlong Liu, Junlong Wu, Honglei Zhang, Rui Zuo, Jiabin Liu and Chao Zhang

Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway

Osteoporosis is a common disease closely associated with aging. In this study, we aimed to investigate the role of Cornuside I in promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs) and...

Authors: Feng Gao, Sheng-Li Xia, Xiu-Hui Wang, Xiao-Xiao Zhou and Jun Wang

Lateral entry pins and Slongo’s external fixation: which method is more ideal for older children with supracondylar humeral fractures?

The standard surgical treatment for supracondylar humeral fractures in children is closed reduction and percutaneous pinning. Given the need for greater fixation strength and higher risk of joint stiffness for...

Authors: Man He, Qian Wang, Jingxin Zhao, Yu Jin and Yu Wang

CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, and fibroblast-like synoviocytes (FLSs) are key effector cells in RA development. Mounting evidence indicates that circular RNAs (circRNAs) pa...

Authors: Zhihuan Luo, Shaojian Chen and Xiaguang Chen

Therapeutic analysis of Herbert screw fixation for capitellar fractures via the anterior approach in adolescent patients

The aim of this study is to analyze the efficacy of open reduction and Herbert screw fixation for coronal fractures of the capitellum via the anterior approach in adolescents.

Authors: Lingpeng Ju, Linjun Jiang, Yuan Zhang, Jun Wu, Ming Li, Xing Liu and Xiangyang Qu

Intraoperative blood loss as indicated by haemoglobin trend is a predictor for the development of postoperative spinal implant infection—a matched-pair analysis

With a reported rate of 0.7–20%, postoperative spinal implant infection (PSII) is one of the most common complications after spine surgery. While in arthroplasty both haematoma formation and perioperative bloo...

Authors: Friederike Schömig, Justus Bürger, Zhouyang Hu, Axel Pruß, Edda Klotz, Matthias Pumberger and Christian Hipfl

Circ-SPG11 knockdown hampers IL-1β-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5

Osteoarthritis (OA) is responsible for the impotent disability in old people. Circular RNA (circRNA) has been reported to be related to the development of diseases. The lack of research on the role of circRNA ...

Authors: Yongqiang Liu, Qian Li, Zhida Gao, Fang Lei and Xuefeng Gao

The biomechanical effect on the adjacent L4/L5 segment of S1 superior facet arthroplasty: a finite element analysis for the male spine

The superior facet arthroplasty is important for intervertebral foramen microscopy. To our knowledge, there is no study about the postoperative biomechanics of adjacent L4/L5 segments after different methods o...

Authors: Zewen Shi, Lin Shi, Xianjun Chen, Jiangtao Liu, Haihao Wu, Chenghao Wang, Zeming Chen, Fang Yang, Sheng Yu and Qingjiang Pang

Confidence level, challenges, and obstacles faced by orthopedic residents in obtaining informed consent

The objective is to evaluate the opinions of orthopedic residents on current practices, experiences, training, confidence level, difficulties, and challenges faced when obtaining informed consent.

Authors: Abdulaziz Z. Alomar

How much improvement can satisfy patients? Exploring patients’ satisfaction 3 years after total knee arthroplasty

Despite the innovations in total knee arthroplasty (TKA), there is still a subset of patients who do not acquire significant relief or expected satisfaction after primary TKA. However, this subgroup of patient...

Authors: Xiao Yu Fan, Jin Hui Ma, Xinjie Wu, Xin Xu, Lijun Shi, Tengqi Li, Peixu Wang, Chengxin Li, Zhizhuo Li, Qing Yu Zhang and Wei Sun

The EOS 3D imaging system reliably measures posterior tibial slope

One of the values determined during the assessment of knee issues is the posterior tibial slope (PTS). A new option for measuring the PTS is the EOS 3D imaging system, which provides anteroposterior (AP) and l...

Authors: Andreas Hecker, Till D. Lerch, Rainer J. Egli, Emanuel F. Liechti and Frank M. Klenke

Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician

Hip fractures are common in elderly patients, in whom it is important to monitor blood loss; however, unnecessary transfusions should be avoided. The primary objective of this study was to assess whether the e...

Authors: Marco Quaranta, Luca Miranda, Francesco Oliva, Filippo Migliorini, Gabriela Pezzuti and Nicola Maffulli

The comparison between anterior and posterior approaches for removal of infected lumbar interbody cages and a proposal regarding the use of endoscope-assisted technique

In cases of postoperative deep wound infection after interbody fusion with cages, it is often difficult to decide whether to preserve or remove the cages, and there is no consensus on the optimal approach for ...

Authors: Yun-Da Li, Jia-En Chi, Ping-Yeh Chiu, Fu-Cheng Kao, Po-Liang Lai and Tsung-Ting Tsai

Increased acromiohumeral distance in a double-row arthroscopic rotator cuff surgery compared to a single-row surgery after 12 months

Arthroscopic rotator cuff surgery is an effective treatment for rotator cuff tears with the considered use of double-row repair techniques becoming popular in the last decade. We aim to compare the effects of ...

Authors: Kaya Turan, Haluk Çabuk, Cenk Köroğlu and Çağatay Öztürk

Comparison of SDSG and CARDS classifications for L5/S1 lumbar degenerative spondylolisthesis: an independent inter- and intra-observer agreement study

Lumbar degenerative spondylolisthesis (DS) has been a common disease that makes increasing patients to suffer from different degrees of low back pain and radicular symptoms. The Spinal Deformity Study Group (S...

Authors: Zhengwang Sun, Chongqing Xu, Mengchen Yin and Wangjun Yan

Accuracy of tibial tuberosity-trochlear groove distance and tibial tuberosity-posterior cruciate ligament distance in terms of the severity of trochlear dysplasia

Increased tibial tubercle-trochlear groove distance (TT-TG) was proposed as one of the main risk factors for patellofemoral instability (PFI). The increased TT-TG distance indicated externalization of the tibi...

Authors: Conglei Dong, Chao Zhao, Ming Li, Chongyi Fan, Xunkai Feng, Kang Piao, Kuo Hao and Fei Wang

Efficacy and safety of a self-developed home-based enhanced knee flexion exercise program compared with standard supervised physiotherapy to improve mobility and quality of life after total knee arthroplasty: a randomized control study

This randomized controlled study compared standard supervised physiotherapy (SPT) with a self-developed, home-based, enhanced knee flexion exercise program involving a low stool (KFEH) in patients who underwen...

Authors: Tianyang Xu, Dong Yang, Kaiyuan Liu, Qiuming Gao, Hengli Lu, Yue Qiao, Chunyan Zhu and Guodong Li

Patellar retraction versus eversion on functional outcomes in total knee replacement: a randomized controlled study protocol

Patellar mobilization technique during total knee replacement (TKR) has been debated, with some suggesting that lateral retraction, rather than eversion, of the patella may be beneficial. This randomized contr...

Authors: Zhao Wang, Yong Ji, Hongwei Bao, Jingzhao Hou and Yan-xiao Cheng

Biportal endoscopic posterior lumbar decompression and vertebroplasty for extremely elderly patients affected by lower lumbar delayed vertebral collapse with lumbosacral radiculopathy

Lower lumbar osteoporotic vertebral compression fracture in extremely elderly patients can often lead to lumbosacral radiculopathy (LSR) due to delayed vertebral collapse (DVC). Surgical intervention requires ...

Authors: Min-Seok Kang, Dong-Hwa Heo, Hoon-Jae Chung, Ki-Han You, Hyong-Nyun Kim, Jun-Young Choi and Hyun-Jin Park

Expression of VEGF-A Signaling Pathway in Cartilage of ACLT-induced Osteoarthritis Mouse Model

Anterior cruciate ligament transection surgery (ACLT)-induced OA model was often used to investigate the molecular mechanism of knee osteoarthritis (KOA). Researches have shown that vascular endothelial growth...

Authors: Jia-jia Qian, Qi Xu, Wei-min Xu, Ren Cai and Gui-cheng Huang

Conservative versus tailored surgical treatment in patients with first time lateral patella dislocation: a randomized-controlled trial

Patellar instability has a high incidence and occurs particularly in young and female patients. If the patella dislocates for the first time, treatment is usually conservative. However, this cautious approach ...

Authors: M. Liebensteiner, A. Keiler, R. El Attal, P. Balcarek, F. Dirisamer, J. Giesinger, G. Seitlinger, M. Nelitz, A. Keshmiri, J. Frings, Ch. Becher, P. Kappel, D. Wagner and G. Pagenstert

Sonication fluid culture of antibiotic-loaded bone cement spacer has high accuracy to confirm eradication of infection before reimplantation of new prostheses

Sonication fluid culture of antibiotic-loaded bone cement spacer has been used to predict reinfection of two-stage revision, but its value remains disputable. This study aims to evaluate the association betwee...

Authors: Qingyu Zhang, Baocong Ding, Jinglin Wu, Jun Dong and Fanxiao Liu

Suprascapular nerve block is a clinically attractive alternative to interscalene nerve block during arthroscopic shoulder surgery: a meta-analysis of randomized controlled trials

The interscalene brachial plexus block (ISB) is a commonly used nerve block technique for postoperative analgesia in patients undergoing shoulder arthroscopy surgery; however, it is associated with potentially...

Authors: Changjiao Sun, Xiaolin Ji, Xiaofei Zhang, Qi Ma, Peng Yu, Xu Cai and Huadong Yang

Long-term outcomes of cementless femoral stem revision with the Wagner cone prosthesis

The procedure of femoral stem revision is challenging, and bone conservation with less stress shielding is a mandatory effort in these cases. Although there are several reports of stem revision with stems desi...

Authors: Kyung-Soon Park, Sheng-Yu Jin, Jun-Hyuk Lim and Taek-Rim Yoon

Logistic regression analysis on risk factors of augmented vertebra recompression after percutaneous vertebral augmentation

To explore the high-risk factors of augmented vertebra recompression after percutaneous vertebral augmentation (PVA) in the treatment of osteoporotic vertebral compression fracture (OVCF) and analyze the corre...

Authors: Zhongcheng An, Chen Chen, Junjie Wang, Yuchen Zhu, Liqiang Dong, Hao Wei and Lianguo Wu

The efficacy and safety of tranexamic acid in high tibial osteotomy: a systematic review and meta-analysis

The present meta-analysis was conducted to evaluate the efficacy and safety of the application of tranexamic acid (TXA) in patients undergoing high tibial osteotomy (HTO).

Authors: Jimin Ma, Hanli Lu, Xinxing Chen, Dasai Wang and Qiang Wang

Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among midd...

Authors: Haoyu He, Huaxiang Lu, Shuzhen Liu, Jiansheng Cai, Xu Tang, Chunbao Mo, Xia Xu, Quanhui Chen, Min Xu, Chuntao Nong, Qiumei Liu, Junling Zhang, Jian Qin and Zhiyong Zhang

MiR-24-3p attenuates IL-1β-induced chondrocyte injury associated with osteoarthritis by targeting BCL2L12

MiR-24-3p has been reported to be involved in an osteoarthritis (OA)-resembling environment. However, the functional role and underlying mechanism of miR-24-3p in chondrocyte injury associated with OA remains ...

Authors: Jin Xu, Xiaozhong Qian and Ren Ding

Clinical outcome of femoral neck system versus cannulated compression screws for fixation of femoral neck fracture in younger patients

The clinical outcome of a new fixation device (femoral neck system, FNS) for femoral neck fractures remains unclear. The main purpose of this study was to evaluate two different internal fixation methods for t...

Authors: Huaijian Hu, Jingbo Cheng, Mingli Feng, Zhihua Gao, Jingwei Wu and Shibao Lu

The use of extracorporeal shock wave therapy for the treatment of bone marrow oedema — a systematic review and meta-analysis

Extracorporeal shock wave therapy (ESWT) has been used for various pathologies associated with bone marrow oedema (BME). However, it is still not clear whether ESWT may be favourable in the treatment of BME. T...

Authors: Jonathan Häußer, Juliane Wieber and Philip Catalá-Lehnen

Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration ...

Authors: Qi Sun, Xin-Yu Nan, Fa-Ming Tian, Fang Liu, Shao-Hua Ping, Zhuang Zhou and Liu Zhang

Abstaining from symptomatic implants of modified tension band wiring by nonabsorbable suture fixation for transverse patella fractures

Modified tension band fixation has become commonly used for transverse patella fractures. The conventional stainless steel wire provides sufficient stability but may be associated with complications.

Authors: Puripun Jirangkul and Arkaphat Kosiyatrakul

Comparison of lateral entry and crossed entry pinning for pediatric supracondylar humeral fractures: a meta-analysis of randomized controlled trials

Closed reduction and pinning entry fixation have been proposed as treatment strategies for displaced supracondylar humeral fractures (SCHFs) in children. However, controversy exists regarding the selection of ...

Authors: Huaguo Zhao, Song Xu, Guanyi Liu, Jingyu Zhao, Shandong Wu and Linrui Peng