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  1. Although conservative treatment with circular plaster cast is the most commonly used method in distal radius fractures, the best method to apply it remains unclear.

    Authors: Alejandro Espejo-Reina, María T. Carrascal-Morillo and Alberto D. Delgado-Martínez
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:99
  2. In orthopedic application, stress-shielding effects of implant materials cause bone loss, which often induces porosis, delayed bone healing, and other complications. We aimed to compare the stress-shielding ef...

    Authors: Xinwen Zhao, Wensen Jing, Zhe Yun, Xun Tong, Zhao Li, Jiajia Yu, Yaohui Zhang, Yabin Zhang, Zhixue Wang, Yanhua Wen, Heping Cai, Jun Wang, Baoan Ma and Haien Zhao
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:97
  3. The concept of minimally invasive surgery (MIS) was introduced in total knee arthroplasty (TKA) in the late 1990s. The number of MIS TKAs has clearly decreased in recent years. An implant designed specifically...

    Authors: Shinya Toyoda, Takao Kaneko, Yuta Mochizuki, Masaru Hada, Kazutaka Takada, Hiroyasu Ikegami and Yoshiro Musha
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:95
  4. Intramedullary nailing (IMN) is a conventional technique for the treatment of tibial shaft fractures. It has been suggested that the suprapatellar (SP) approach holds advantages over the traditional infrapatel...

    Authors: Nikhil Ponugoti, Branavan Rudran, Amr Selim, Sam Nahas and Henry Magill
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:94
  5. The rate of postoperative infection developing is higher after limb salvage surgery (LSS) following sarcoma resection compared with conventional arthroplasty. The goal of this study is to summarize our experie...

    Authors: Tiao Lin, Qinglin Jin, Xiaolin Mo, Zhiqiang Zhao, Xianbiao Xie, Changye Zou, Gang Huang, Junqiang Yin and Jingnan Shen
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:93
  6. The central ridge of the patella is the thickest area of patella and varies among patients. This cadaveric study identified the location and thickness of the bone at the central patella ridge for bone-patellar...

    Authors: Thanathep Tanpowpong, Thun Itthipanichpong, Thanasil Huanmanop, Nonn Jaruthien and Nattapat Tangchitcharoen
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:92
  7. Limited information exists on the incidence of postoperative deep venous thromboembolism (DVT) in patients with isolated patella fractures. The objective of this study was to investigate the postoperative inci...

    Authors: Zhanchao Tan, Hongzhi Hu, Xiangtian Deng, Jian Zhu, Yanbin Zhu, Dandan Ye, Xiaodong Cheng and Yingze Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:90
  8. The transiliac-transsacral screw placement is a clinical challenge for surgeons. This study explored a point-to-point coaxial guide apparatus assisting the transiliac-transsacral screw insertion and aimed to i...

    Authors: Ze-hang Zheng, Fei Xu, Zheng-qiang Luo, Ye Ren, Tao Fu, Han-qing Xu and Bin-bin Liu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:89
  9. Regarding the repair of vertebral compression fractures, there is a lack of adequate biomechanical verification as to whether only half of the vertebral body and the upper and lower intervertebral discs affect...

    Authors: Ye Han, Xiaodong Wang, Jincheng Wu, Hanpeng Xu, Zepei Zhang, Kepeng Li, Yang Song and Jun Miao
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:88
  10. To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of c...

    Authors: Yiqin Zhou, Haobo Li, Dong Xiang, Jiahua Shao, Qiwei Fu, Yaguang Han, Jun Zhu, Yi Chen and Qirong Qian
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:87
  11. The aim of the present study was to explore the therapeutic effect and prognosis in patients with rib fractures and atelectasis after thoracic trauma in order to provide a basis for clinical decision-making in...

    Authors: Degang Yin, Jingang Lu, Jiansheng Wang, Biao Yan and Zhongshu Zheng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:86
  12. Previous studies showed overexpression of ABCG2 in a variety of tumor tissues, which could potentially indicate the probability of chemotherapy resistance. This study aimed to reveal the role of ABCG2 in the d...

    Authors: Hao Shu, Bin Yuan, Yao Huang, Lei Wang, Bing He, Qi Sun and Luning Sun
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:85
  13. Previous evidence suggested that perioperative anti-rheumatic therapy for patients receiving total knee arthroplasty (TKA) helped improve postoperative rehabilitation for rheumatoid arthritis (RA), yet long-te...

    Authors: Yi Ren, Qi Yang, Tim Luo, Jin Lin, Jin Jin, Wenwei Qian, Xisheng Weng and Bin Feng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:84
  14. Whether resurface the patella or not in total knee arthroplasty (TKA) was controversial. In 2013, we conducted a meta-analysis of randomized controlled trials (RTCs). After that, plenty of studies have been ca...

    Authors: Kai Chen, Xiaoyu Dai, Lidong Li, Zhigang Chen, Haidong Cui and Shujun Lv
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:83
  15. To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients.

    Authors: Jian Xiang Wu, Jiang Hui Qing, Yao Yao, Dong Yang Chen and Qing Jiang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:82
  16. The aim of this study was to evaluate the efficacy of local infiltration anaesthesia (LIA) during primary total hip arthroplasty (THA) via a posterolateral approach under general anaesthesia and to compare the...

    Authors: Qiang Xiao, Bing Xu, Haoyang Wang, Zhenyu Luo, Mingcheng Yuan, Zongke Zhou and Fuxing Pei
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:81
  17. Only a few studies have described the effect of full arthroscopic surgery in treatment of excessive lateral pressure syndrome (ELPS). Therefore, the purpose of this study was to assess the clinical efficacy an...

    Authors: Cheng-Liang Wang, Ji-Bin Chen and Te Li
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:80
  18. Alumina-titanium (Al2O3-Ti) biocomposites have been recently developed with improved mechanical properties for use in heavily loaded orthopedic sites. Their biological performance, however, has not been investiga...

    Authors: Marjan Bahraminasab, Samaneh Arab, Manouchehr Safari, Athar Talebi, Fatemeh Kavakebian and Nesa Doostmohammadi
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:79
  19. Periprosthetic fractures of the distal femur above a total knee arthroplasty (TKA) have traditionally been managed by locking compression plating (LCP). This technique is technically demanding and is associate...

    Authors: Henry Magill, Nikhil Ponugoti, Amr Selim and James Platt
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:78
  20. As the ultimate method for the treatment of osteoarthritis, total knee arthroplasty (TKA) has been widely used in the clinic. Local injection of multimodal cocktails, including corticosteroids, is commonly use...

    Authors: Qi Li, Guo Mu, Xiangbo Liu and Milian Chen
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:77

    The Correction to this article has been published in Journal of Orthopaedic Surgery and Research 2021 16:200

  21. The risk factors of postoperative delirium (POD), a serious while preventable complication, developed by patients undergoing knee and replacement surgery are still under investigation. In this systematic revie...

    Authors: Xiao Rong, Zi-chuan Ding, Hao-da Yu, Shun-Yu Yao and Zong-Ke Zhou
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:76
  22. The rapid progressive cervical spondylotic myelopathy (rp-CSM) which had a course of CSM less than 1 month and suffered rapidly progressive neurological deterioration had few reports. Therefore, it is importan...

    Authors: Weiyang Zhong, Lin Wang, Tianji Huang and Xiaoji Luo
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:75
  23. Mandibular fracture healing is a complex process involving nerves and growth factors. Nerve growth factor (NGF) not only facilitates the maintenance of sympathetic neurite growth but also stimulates other grow...

    Authors: Sen Yang, Jiao Cheng, Cheng Man, Lian Jiang, Guogeng Long, Wenjun Zhao and Dexin Zheng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:74
  24. Percutaneous vertebroplasty (PVP) is a routine operation for the treatment of osteoporotic lumbar compression fractures (OLCFs). As is well known, unilateral puncture is a common method. However, with the conv...

    Authors: Wenwu Zhang, Shenpeng Liu, Xianhua Liu, Xiang Li, Le Wang and Yong Wan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:73
  25. Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling ...

    Authors: Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa and Haruhiko Tokuda
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:72
  26. Bone neoplasms present poor prognosis due to recurrence and metastasis. Although the role microRNAs (miRNAs) in inhibiting growth and metastasis of bone neoplasms has been investigated, the underlying potentia...

    Authors: Yang Li, Xiaotao Long, Ji Wang, Jing Peng and Kai Shen
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:71
  27. To retrospectively analyze the clinical efficacy of PFNA combined with a cerclage wire in the treatment of 52 patients with unstable subtrochanteric fracture of the femur and to analyze the biomechanical effec...

    Authors: Xiaowei Huang, Fangxue Zhang and Yong Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:70
  28. This study was performed to compare the advantage and disadvantage of posterolateral approach (PLA) and direct anterior approach (DAA) in total hip arthroplasty (THA).

    Authors: Xuedong Sun, Xueli Zhao, Licheng Zhou and Zheng Su
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:69
  29. Osteoarthritis (OA) is a leading cause of disability. The incidence of OA is progressively rising due to the diminishing levels of physical activity and ever-expanding aging population. However, the mainstay f...

    Authors: Zhenxing Si, Shifeng Zhou, Zilong Shen, Feiyu Luan and Jinglong Yan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:68
  30. Short tapered stem placement has been extensively employed in total hip arthroplasty (THA). Suboptimal fixation tends to cause postoperative complications, such as thigh pain. However, it remains unclear wheth...

    Authors: Zhijie Chen, Bin Li, Kaizhe Chen, Jianmin Feng, Yi Wang, Zhihong Liu and Chuan He
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:67
  31. The purpose of this study was to investigate the correction error associated with soft tissue balance in high tibial osteotomy (HTO) and the difference between opening wedge HTO (OWHTO) and closed wedge HTO (C...

    Authors: Ken Kumagai, Hiroshi Fujimaki, Shunsuke Yamada, Shuntaro Nejima, Joji Matsubara and Yutaka Inaba
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:66
  32. Percutaneous kyphoplasty is the main method in the treatment of thoracolumbar osteoporotic compression fractures. However, much radiation exposure during the operation harms the health of surgeons and patients...

    Authors: Boyao Wang, Jiang Cao, Jie Chang, Guoyong Yin, Weihua Cai, Qingqing Li, Zhenfei Huang, Lipeng Yu and Xiaojian Cao
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:65
  33. Knowledge regarding the pathogenesis of osteoarthritis (OA) is very limited. Previous studies have shown that matrix metalloproteinase (MMP) 8 and MMP9 were upregulated in patients with diabetic OA. However, t...

    Authors: Simin Luo, Wuji Li, Wenrui Wu and Qiping Shi
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:64
  34. Osteoarthritis (OA) is a chronic degenerative joint disease and the most frequent type of arthritis. This study aimed to identify the key miRNAs and genes associated with OA progression.

    Authors: Pei-yan Huang, Jun-guo Wu, Jun Gu, Tie-qi Zhang, Ling-feng Li, Si-qun Wang and Minghai Wang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:63
  35. Inequalities in leg length result in functional disorders, as they impair the biomechanics of the musculoskeletal system, significantly reducing the quality of life (QoL). This study used the WHOQoL-BREF quest...

    Authors: Łukasz Pawik, Malwina Pawik, Zdzisława Wrzosek, Felicja Fink-Lwow and Piotr Morasiewicz
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:62
  36. Persistent post-operative pain (PPOP) has detracted from some otherwise successful knee arthroplasties. This study investigated medial abrasion syndrome (MAS) as a cause of PPOP after knee arthroplasty. The su...

    Authors: Shaw-Ruey Lyu, Chia-Chen Hsu and Jung-Pin Hung
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:61
  37. Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress and ...

    Authors: Jiajia Zhang, Ya-nan Wang, Tingting Jia, Haiyun Huang, Dongjiao Zhang and Xin Xu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:59
  38. Fractures of the base of the coracoid process are relatively rare, but an increasing number of studies have reported using screws to fix coracoid process base fractures. This study was performed to simulate th...

    Authors: Zhongye Sun, Hao Li, Bei Wang, Jun Yan, Liren Han, Shizhang Han, Xiaofei Yang and Bei Zhao
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:58
  39. Recent work has shed light on the potential benefits of cannabinoids for multimodal pain control following orthopedic procedures. The objective of this review was to summarize the available evidence of analges...

    Authors: Bradley J. Vivace, Allyson N. Sanders, Steven D. Glassman, Leah Y. Carreon, Joseph L. Laratta and Jeffrey L. Gum
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:57
  40. Particulated juvenile allograft cartilage (PJAC) has a good short-term clinical efficacy in repairing articular cartilage defects, but the proliferation ability of PJAC and the biological characteristics of tr...

    Authors: Changgui Zhang, Xingyu Zhao, Yunong Ao, Jin Cao, Liu Yang and Xiaojun Duan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:56
  41. Intervertebral disk degeneration (IDD) is a degenerative disease characterized by cytoplasm loss and extracellular matrix degradation. Numerous evidence reported that miRNAs participated in IDD development. Ne...

    Authors: Jianmin Xue, Baoyang Hu, Wenhua Xing, Feng Li, Zhi Huang, Wenkai Zheng, Bo Wang, Yong Zhu and Xuejun Yang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:55
  42. Femoral neck fractures are still unsolved problems nowadays; sliding hip screw (SHS) and cannulated compression screw (CCS) are the most commonly used devices. We evaluated the clinical outcomes and complicati...

    Authors: Yutong Xia, Wendong Zhang, Zhen Zhang, Jingcheng Wang and Lianqi Yan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:54
  43. This study aimed to evaluate the efficacy and safety of using high-dose intravenous tranexamic acid (TXA) to reduce blood loss in idiopathic scoliosis surgery.

    Authors: Indra K. Shrestha, Tian-Yi Ruan, Lan Lin, Miao Tan, Xue-Qing Na, Qi-Cai Qu, Jian-Chun Chen, Yong-Yu Si and Jian-Ping Tao
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:53
  44. No large series have analysed distally based sural fasciocutaneous (DBSF) flaps in paediatric patients. The aims of this study were to assess the reliability and analyse the potential risk factors for these fl...

    Authors: Zhaobiao Luo, Jiangdong Ni, Guohua Lv, Jianwei Wei, Lihong Liu, Ping Peng and Zhonggen Dong
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:52
  45. Osseointegration is the premise of the chewing function of dental implant. Nerve growth factor (NGF), as a neurotrophic factor, can induce bone healing. However, the influence of NGF-chondroitin sulfate (CS)/h...

    Authors: Jun Ye, Bo Huang and Ping Gong
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:51
  46. Circular RNAs (circRNAs) have been shown to participate in the chemoresistance and tumorigenesis of multiple cancers. The purpose of this research was to investigate the function of circ_0081001 in methotrexat...

    Authors: Wei Wei, Liefeng Ji, Wanli Duan and Jiang Zhu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:50

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