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  1. Soft tissue balancing is essential for the success of total knee arthroplasty (TKA) and is mainly dependent on surgeon-defined assessment (SDA) or a gap-balancer (GB). However, an electronic sensor has been de...

    Authors: Ran Zhao, Yanqing Liu and Hua Tian
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:305
  2. This systematic review was conducted to gather available evidence on the effectiveness of muscle pedicle bone flap transplantation in adult patients with femoral neck fractures.

    Authors: Yipeng Wu, Muguo Song, Guangliang Peng, Yongqing Xu, Yang Li, Mingjie Wei, Hui Tang, Qian Lv, Teng Wang and Xingbo Cai
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:304
  3. Previous study showed that circular RNA Absent-Small-Homeotic-2--Like protein (circASH2L) was higher in rheumatoid arthritis (RA) patients. However, the roles and mechanisms of circASH2L in RA progression rema...

    Authors: Xia Li, Meiting Qu, Jie Zhang, Kuanyin Chen and Xianghui Ma
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:302
  4. To analyze the effect of sacrificing the posterior cruciate ligament (PCL) on the early postoperative outcome of cruciate retaining (CR) highly congruent rotating platform TKA.

    Authors: Long Chen, Jie Xu, Yuan Lin, Fen Qi Luo and Yu Guo Yu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:299
  5. We aimed to evaluate reliability, radiological outcomes, and the impacts of anterior cervical hybrid construction on the adjacent segments for the multilevel cervical degenerative disc disease (mCDDD) and spon...

    Authors: Murat Yilmaz, Kemal Yucesoy, Resat S. Erbayraktar and Rıfat S. Altinag
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:298
  6. Angiotensin II (Ang II) is associated with rheumatoid arthritis (RA) development. The present study investigated the impact of Ang II on the expression of receptor activator of nuclear factor-κB ligand (RANKL)...

    Authors: Zhiping Zhao, Yongtao Zhang, Changyao Wang, Xiangyu Wang, Yingzhen Wang and Haining Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:297
  7. To explore the impact of different repair methods for a lateral meniscus posterior root tear on the biomechanics of the knee joint using finite element analysis.

    Authors: Jian-Yu Wang, Yan-Song Qi, Hu-Ri-Cha Bao, Yong-Sheng Xu, Bao-Gang Wei, Yong-Xiang Wang, Bing-Xian Ma, Hui-Wen Zhou and Fei Lv
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:296
  8. In tibial plateau fractures (TPF) the restoration of an anatomical joint surface as well as an exact subchondral screw position for postoperative stability is crucial for the outcome.

    Authors: F. Souleiman, R. Henkelmann, J. Theopold, J. Fakler, U. Spiegl and P. Hepp
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:295
  9. Osteosarcoma is a disease with high mortality in children and adolescents, and metastasis is one of the important clinical features of osteosarcoma. N6-Methyladenosine (m6A) is the most abundant methylation modif...

    Authors: Hua Liu, Guangzhen Qin, Yanan Ji, Xiaojian Wang, Hailin Bao, Xiaojun Guan, Aichun Wei and Zhigang Cai
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:294
  10. Peritendinous adhesion is among the common complications after tendon injury. Numerous studies have been carried out to prevent its formation, including modifications of surgical procedures, postoperative care...

    Authors: Pengfei Li, Haiying Zhou, Tian Tu and Hui Lu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:293
  11. Culture-negative periprosthetic joint infections (PJIs) can complicate diagnosis and management of PJI. This study aimed to identify risk factors for culture-negative PJI and differences in clinical characteri...

    Authors: Shintaro Watanabe, Naomi Kobayashi, Akito Tomoyama, Hyonmin Choe, Etsuko Yamazaki and Yutaka Inaba
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:292
  12. Some unusual rotator cuff (RC) tears are located in more proximal tendinous portions, with substantial remnant tissue attached to the footprint. The two options for surgical repair are sacrificing or preservin...

    Authors: Hyung-Suk Choi, Byung-Ill Lee, Jae-Hyung Kim, Hyung-Ki Cho and Gi-Won Seo
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:291
  13. Osteoarthritis (OA) is a complex joint disease and chronic pain source, affecting a patient’s quality of life and posing a financial burden. As the dog is considered a nearly ideal species for translation rese...

    Authors: J. C. Alves, Ana Margarida Moniz Pereira dos Santos, Patrícia Jorge, Catarina Falcão Trigoso Vieira Branco Lavrador and L. Miguel Carreira
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:290
  14. Lateral tibial plateau fractures (TPFs) are often treated with conventional open reduction and internal fixation (ORIF) through standard anterolateral sub-meniscal arthrotomy. There has been increasing support...

    Authors: Xiangtian Deng, Hongzhi Hu, Yiran Zhang, Weijian Liu, Qingcheng Song, Xiaodong Cheng, Jian Zhu, Sifan Yang, Zhipeng Ye, Haitao Guan, Boyu Zhang, Zhanle Zheng and Yingze Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:289
  15. The long pentraxin PTX3 is generating great interest given the recent discovery of its involvement in bone metabolism. This study investigates the role of circulating PTX3 as a marker of bone-related phenotype...

    Authors: Virginia Veronica Visconti, Chiara Greggi, Simona Fittipaldi, Donato Casamassima, Mariagrazia Tallarico, Francesco Romano, Annalisa Botta and Umberto Tarantino
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:288

    The Correction to this article has been published in Journal of Orthopaedic Surgery and Research 2021 16:331

  16. To describe a new technique for implanting a double-bundle titanium cable to treat acromioclavicular (AC) joint dislocation via the new guider, and evaluate clinic outcomes.

    Authors: Jun Wang, Yongfeng Cui, Yuhang Zhang and Hang Yin
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:287
  17. This study is to describe the design and surgical techniques of three- dimensional-printed porous implants for proximal giant cell tumors of bone and evaluate the short-term clinical outcomes.

    Authors: Yuqi Zhang, Minxun Lu, Li Min, Jie Wang, Yitian Wang, Yi Luo, Yong Zhou, Hong Duan and Chongqi Tu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:286
  18. To investigate the clinical efficacy of locking compression plate fixation for the treatment of femoral intertrochanteric fractures in patients with preexisting proximal femoral deformity.

    Authors: Shan Fan, Mingming Yin, Yibo Xu, Cheng Ren, Teng Ma, Yao Lu, Ming Li, Zhong Li and Kun Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:285
  19. To evaluate the effect of postoperative BP treatment on improving the fusion rate after lumbar spinal fusion surgery by performing a meta-analysis of randomized controlled trials (RCTs) and other comparative c...

    Authors: Jun Mei, Xiaoxu Song, Xiaoming Guan, Dou Wu, Junjie Wang and Qiang Liu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:284
  20. Platelet-rich plasma (PRP) has been used to favor anterior cruciate ligament (ACL) healing after reconstruction surgeries. However, clinical data are still inconclusive and subjective about PRP. Thus, we propo...

    Authors: Allan Felipe Fattori Alves, José Ricardo de Arruda Miranda, Sérgio Augusto Santana de Souza, Ricardo Violante Pereira, Paulo Roberto de Almeida Silvares, Seizo Yamashita, Elenice Deffune and Diana Rodrigues de Pina
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:283
  21. Osteoarthritis of the knee is a common degenerative joint disorder in our ageing population. A combination of thermal therapy with a self-management exercise have shown a positive effect in the management of o...

    Authors: Kevin Ki-Wai Ho, Anthony Wai-Leung Kwok, Wai-Wang Chau, S. M. Xia, Y. L. Wang and Jack Chun-Yiu Cheng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:282
  22. Nonunion is a rare complication for distal fibular fractures. However, when there is a high degree of comminution, nonunion may occur. In this article, we describe a novel technique that uses the oblong hole o...

    Authors: Young Uk Park, Sung Jae Kim and Hyong Nyun Kim
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:281
  23. The overarching goal of our research was to compare the clinical and radiological outcomes with different sizes of cages implantation in anterior cervical discectomy and fusion (ACDF), and to evaluate the effe...

    Authors: Changyan Wu, Xiaojuan Yang, Xu Gao, Liwei Shao, Fang Li, Yunxin Sun, Xiaoyu Liu, Shuaihao Yao and Yifu Sun
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:280
  24. Curculigoside is a natural phenolic glycoside compound produced by Curculigo orchioides Gaertn. This study aimed to explore the effects of curculigoside in promoting the osteogenic differentiation of adipose-deri...

    Authors: Wei-Li You and Zheng-Long Xu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:279
  25. The association of the severity of clinical symptoms and level of functional performance with the degree of magnetic resonance imaging abnormalities in patients with lateral epicondylitis has not been fully el...

    Authors: Seok Woo Hong, Jeong-Hyun Kang, Jin Hun Park, Ji Na Kim, Hee Jin Park and Eugene Kim
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:278
  26. To explore the clinical efficacy of posterior LFF for cervical OPLL with radicular pain of upper limbs

    Authors: Bao Su, Jieliang Shen, Xiaoji Luo, Zhengxue Quan, Dianming Jiang, Xiaohua Peng and Ke Tang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:277
  27. Higher pedicle screw density posterior spinal fusion (PSF) constructs have not been shown to result in improved curve correction in Lenke 1 and 5 adolescent idiopathic scoliosis (AIS) but do increase cost. The...

    Authors: Timothy J. Skalak, Joel Gagnier, Michelle S. Caird, Frances A. Farley and Ying Li
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:276
  28. Hemophilic pseudotumor (HPT)-related fracture is a rare but severe complication in patients with HPTs. These fractures often occur in femurs. There is no consensus on the standard surgical protocol for HPT-rel...

    Authors: Keyu Chen, Guiyong Jiang, Yaowen Xu, Yunping Yang, Zexiong Mao, Jiaxin Lv, Fei Liu and Bin Chen
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:275
  29. To develop and validate a nomogram useful in predicting recurrent lumbar disk herniation (rLDH) within 6 months after percutaneous endoscopic lumbar discectomy (PELD).

    Authors: Mengxian Jia, Yadong Sheng, Guoliang Chen, Wenbin Zhang, Jiajin Lin, Sheng Lu, Fayi Li, Jinwei Ying and Honglin Teng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:274
  30. The purpose of present study was to identify the differentially expressed genes (DEGs) associated with BMP-9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by using bioinformatics methods.

    Authors: Jia-qi Wu, Lin-bo Mao, Ling-feng Liu, Yong-mei Li, Jian Wu, Jiao Yao, Feng-huan Zhang, Ting-yu Liu and Ling Yuan
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:273
  31. The purpose of the current study was to explore the role and underlying mechanism of cellular retinoic acid binding protein 2 (CRABP2) in dexamethasone (DEX)-induced apoptosis in human osteoblast cells.

    Authors: Haiping Zhang, Ziliang Yu, Farui Sun and Jin Jin
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:272
  32. Posterior hemivertebra resection and short-segment fusion with pedicle screws are an established treatment in congenital scoliosis, which require pediatric-specific instrumentation. The purpose of this study w...

    Authors: Mohammad Zarei, Ehsan Ghadimi, Nima Bagheri, Seyed Mir Mansour Moazen Jamshidi, Alireza Moharrami, Mersad Moosavi and Soroush Baghdadi
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:271
  33. Implant-associated infections depict a major challenge in orthopedics and trauma surgery putting a high burden on the patients and health care systems, strongly requiring improvement of infection prevention an...

    Authors: Nike Walter, Daniel Popp, Viola Freigang, Michael Nerlich, Volker Alt and Markus Rupp
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:270
  34. Sacral insufficiency fracture (SIF) is rarer than osteoporotic vertebral compression fracture that occurs at other levels of the thoracolumbar spine. Percutaneous sacroplasty can effectively relieve pain and i...

    Authors: Feng-Chen Kao, Yao-Chun Hsu, Tzu-Shan Chen, Pao-Hsin Liu and Yuan-Kun Tu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:269
  35. To analyze and compare the effects of peri-treatment analgesics on acute and chronic pain and postoperative functional recovery of patients with thoracolumbar fractures, so as to guide the clinical drug use.

    Authors: Hao Yuan, Quan-Yuan Chang, Jie Chen, Ya-Ting Wang, Zong-Jin Gan, Song Wen, Ting-Ting Li and Liu-Lin Xiong
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:268
  36. The objectives of this study were to assess radiolucent lines around a highly porous titanium cup (Tritanium) using digital tomosynthesis and to investigate the clinical and radiographic factors associated wit...

    Authors: Kazuki Oishi, Yuji Yamamoto, Yoshifumi Harada, Ryo Inoue, Eiji Sasaki and Yasuyuki Ishibashi
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:266
  37. Surgical site infection (SSI) is a risk in every operation. Infections negatively impact patient morbidity and mortality and increase financial demands. The aim of this study was to analyse SSI and its risk fa...

    Authors: Vera Spatenkova, Ondrej Bradac, Zdenek Jindrisek, Jan Hradil, Daniela Fackova and Milada Halacova
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:265
  38. Isolated patellofemoral osteoarthritis (PF-OA) is a common subtype of knee osteoarthritis, leading to a huge economic burden on health care systems. Although previous studies have shown that patellofemoral art...

    Authors: Guanrong Peng, Min Liu, Zhenhua Guan, Yunfei Hou, Qiang Liu, Xiaobo Sun, Xingyang Zhu, Wenjun Feng, Jianchun Zeng, Zhangrong Zhong and Yirong Zeng
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:264
  39. Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are commonly used for preventing venous thrombosis of the lower extremity in patients with traumatic spinal cord injury. Although, LMWH is t...

    Authors: Ze Lin, Yun Sun, Hang Xue, Lang Chen, Chenchen Yan, Adriana C. Panayi, Bobin Mi and Guohui Liu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:262
  40. Many non-union animal models have been developed to explore the problems surrounding fracture healing. However, the existing models are not perfect and cannot satisfy all non-union studies. This study aimed to...

    Authors: Xue-Qiang Wu, Dong Wang, Yang Liu and Jun-Lin Zhou
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:261
  41. This study was aimed to utilize a modified anterior drawer test (MADT) to detect the anterior cruciate ligament (ACL) ruptures and investigate its accuracy compares with three traditional tests.

    Authors: Guang-lei Zhao, Jin-yang Lyu, Chang-quan Liu, Jian-guo Wu, Jun Xia and Gang-yong Huang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:260
  42. Osteoarthritis (OA) is a worldwide musculoskeletal disorder. However, disease-modifying therapies for OA are not available. Here, we aimed to characterize the molecular signatures of OA and to identify novel t...

    Authors: Song Shi, Fuyin Wan, Zhenyu Zhou, Ran Tao, Yue Lu, Ming Zhou, Fan Liu and Yake Liu
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:259
  43. The management of complex diabetic foot wounds with large skin defects poses a challenge for surgeons. We presented a simple skin stretching system and negative pressure wound therapy for the repair of complex...

    Authors: Yaojun Wu, Liang Chen, Shaokun Wu, Liying Yu, Mimi Chen, Jingnan Wang, Jiejie Chen and Qingjiang Pang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:258
  44. Acromial fractures are rare and there is no consensus on fixation, but an increasing number of studies have reported using two screws to fix Ogawa type I acromial fractures. The objective of this study was to ...

    Authors: Wei Zhang, Zhongye Sun, Weiyan Li, Jun Yan, Liren Han, Shizhang Han, Xiaofei Yang and Bei Zhao
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:257
  45. Accurate femoral neck anteversion angle (FNA) measurement is of great significance in the diagnosis and treatment of developmental dysplasia of the hip (DDH) in children. The FNA measurement still remains a co...

    Authors: Zhencun Cai, Chengzhe Piao, Tianyu Zhang, Lianyong Li and Liangbi Xiang
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:256
  46. Circular RNA (circRNA) has been shown to be associated with osteoarthritis (OA) progression. Circ_0116061 has been found to be highly expressed in OA cartilage tissues, but its role and mechanism in OA progres...

    Authors: Wei Zheng, Guanhua Hou and Yong Li
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:253
  47. The experiment was undertaken to estimate the effect of BMSC seeding in different scaffold incorporation with HBO on the repair of a seawater-immersed bone defect. And future compared n-HA/PLGA with β-TCP/PLGA...

    Authors: Gan Zhang, Xiaosong Chen, Xunsheng Cheng, Wuxiu Ma and Congcong Chen
    Citation: Journal of Orthopaedic Surgery and Research 2021 16:249

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