Articles

Knockdown of miR-660 protects nucleus pulposus cells from TNF-a-induced apoptosis by targeting serum amyloid A1

Intervertebral disc degeneration (IVDD) is a well-known cause of lower back pain, which is induced by multiple factors including increased apoptosis and decreased survival of nucleus pulposus cells. In this st...

Authors: Hao Jie Zhang, Xue Hai Ma, Song Lin Xie, Shu lian Qin, Cong Zhi Liu and Zhen Guo Zhang

Mid-term results after proximal humeral fractures following angular stable plate fixation in elderly patients—which scores can be evaluated by a telephone-based assessment?

The aim was to evaluate postsurgical outcome in elderly patients (> 70 years) after open reduction and internal fixation (ORIF) of proximal humeral fractures and compare the test-retest agreement of scores whi...

Authors: Patrick Ziegler, Kim Stierand, Christian Bahrs and Marc-Daniel Ahrend

Monteggia-like lesions in adults treated with radial head arthroplasty—mid-term follow-up of 27 cases

The aim of the study was to analyze the functional and radiological outcome of Monteggia-like lesions in adults with unreconstructible fracture of the radial head and treatment with radial head arthroplasty.

Authors: Matthias Jung, Corinna Groetzner-Schmidt, Felix Porschke, Paul A. Grützner, Thorsten Guehring and Marc Schnetzke

Endoscopic rhizotomy for chronic lumbar zygapophysial joint pain

Chronic lumbar zygapophysial joint pain is a common cause of chronic low back pain. Percutaneous radiofrequency ablation (RFA) is one of the effective management options; however, the results from the traditio...

Authors: Yuntao Xue, Tao Ding, Dajie Wang, Jianli Zhao, Huilin Yang, Xiaofeng Gu, Dehong Feng, Yafeng Zhang, Hao Liu, Fenglin Tang, Wanyi Wang, Miao Lu and Chao Wu

Different spinal subtypes with varying characteristics of lumbar disc degeneration at specific level with age: a study based on an asymptomatic population

The relationship between spinal sagittal subtypes and lumbar disc degeneration is unclear. Thus, we aimed to investigate the relationship between lumbar intervertebral disc degeneration and age in asymptomatic...

Authors: Shao-qing Chen, Qing-ping Li, Ying-ying Huang, An-na Guo, Rui-fang Zhang, Pei-pei Ye, Zhi-han Yan and Jia-wei He

Predictive formula of cervical lordosis in asymptomatic young population

Not a large number of previous studies have reported the normal sagittal balance of the cervical spine and physiological cervical lordosis (CL) has not been clearly defined yet.

Authors: Yuchen Zhu, Zhongcheng An, Yingjian Zhang, Hao Wei and Liqiang Dong

Pedicle screw placement in spinal neurosurgery using a 3D-printed drill guide template: a systematic review and meta-analysis

Many surgeons believe that the use of a 3D-printed drill guide template shortens operative time and reduces intraoperative blood loss compared with those of the free-hand technique. In this study, we investiga...

Authors: Chengqiang Yu, Yufu Ou, Chengxin Xie, Yu Zhang, Jianxun Wei and Xiaoping Mu

Below-elbow or above-elbow cast for conservative treatment of extra-articular distal radius fractures with dorsal displacement: a prospective randomized trial

Distal radial fractures are common traumatic injuries, but their management remains controversial also in case of conservative treatment regarding the type of immobilisation. Hence, we conducted a two-arm, par...

Authors: Gaetano Caruso, Francesco Tonon, Alessandro Gildone, Mattia Andreotti, Roberto Altavilla, Alessandra Valentini, Giorgia Valpiani and Leo Massari

Topping-off surgery vs posterior lumbar interbody fusion for degenerative lumbar disease: a finite element analysis

Adjacent segment disease (ASD) is a common complication after posterior lumbar interbody fusion (PLIF). Recently, a topping-off surgery (non-fusion with Coflex) has been developed to reduce the risk of ASD, ye...

Authors: Yunpeng Fan, Shaobo Zhou, Tao Xie, Zefeng Yu, Xiao Han and Liulong Zhu

Comparison of the operative time for open door laminoplasty using titanium plate spacers or hydroxyapatite block spacers: a retrospective study

Titanium plate (TP) and hydroxyapatite (HA) spacers are widely used during open-door laminoplasty, performed with the patient in a prone position. Reducing operative time is an important consideration, particu...

Authors: Takahiro Inui, Koichi Inokuchi, Yoshinobu Watanabe, Kentaro Matsui, Yuhei Nakayama, Keisuke Ishii, Takashi Suzuki, Taketo Kurozumi and Hirotaka Kawano

Overstuffing in resurfacing hemiarthroplasty is a potential risk for failure

Literature describes the concern of an overstuffed shoulder joint after a resurfacing humeral head implant (RHHI). The purpose of this study was to evaluate inter-observer variability of (1) the critical shoul...

Authors: Pieter C. Geervliet, Jore H. Willems, Inger N. Sierevelt, Cornelis P. J. Visser and Arthur van Noort

The factors driving self-efficacy in intractable chronic pain patients: a retrospective study

The fear-avoidance model is a theoretical paradigm for explaining acute and chronic pain. In this model, pain catastrophizing plays an important role. On the other hand, self-efficacy influences whether patien...

Authors: Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Haruo Misawa and Toshifumi Ozaki

Clavicle hook plate versus distal clavicle locking plate for Neer type II distal clavicle fractures

The purpose of this meta-analysis was to compare clavicle hook plates versus distal clavicle locking plates for the treatment of Neer type II distal clavicle fractures.

Authors: Liang Li, Tian-yan Li, Peichao Jiang, Guizhen Lin, Hongxiao Wu, Xiaochuan Han and Xuezhong Yu

Prediction of time to prosthesis implantation as a function of joint anatomy in patients with developmental dysplasia of the hip

Developmental dysplasia of the hip (DDH) can lead to pain and premature secondary osteoarthritis at an early stage. Joint-preserving osteotomy is an established solution to this problem. In contrast, a conserv...

Authors: Michael Müller, Anasthasia Rakow, Georgi I. Wassilew, Tobias Winkler and Carsten Perka

Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway

Platelet-rich plasma (PRP) provides a nonsurgical approach for treating osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been studied extensively. Here, we investigated t...

Authors: Xuchang Liu, Lubo Wang, Chengshan Ma, Guozong Wang, Yuanji Zhang and Shui Sun

The short- to midterm effectiveness of stemless prostheses compared to stemmed prostheses for patients who underwent total shoulder arthroplasty: a meta-analysis

To systematically compare the short- to midterm effectiveness of stemless prostheses to that of stemmed prostheses for patients who underwent total shoulder arthroplasty (TSA) and to provide a guideline for cl...

Authors: Wei Peng, Yufu Ou, Chenglong Wang, Jianxun Wei, Xiaoping Mu and Zhian He

Effect of hospital volume on outcomes of total hip arthroplasty: a systematic review and meta-analysis

A shift in the healthcare system towards the centralization of common yet costly surgeries, such as total hip arthroplasty (THA), to high-volume centers of excellence, is an attempt to control the economic bur...

Authors: Syed Hamza Mufarrih, Muhammad Owais Abdul Ghani, Russell Seth Martins, Nada Qaisar Qureshi, Sayyeda Aleena Mufarrih, Azeem Tariq Malik and Shahryar Noordin

Posterior percutaneous endoscopic lumbar discectomy combined with the vertical anchoring technique for lumbar disc herniation with distant upward migration

Posterior percutaneous endoscopic lumbar discectomy (PELD) has become a preferred procedure for the treatment of simple lumbar disc herniation (LDH) but has rarely been reported for distant upward migration. T...

Authors: Yu Xia, Qiongyue Zhang, Xiang Gao, Keran Wang, Xun Zhang, Yu Du and Liang Chen

Plate-related results of opening wedge high tibial osteotomy with a carbon fiber reinforced poly-ether-ether-ketone (CF-PEEK) plate fixation: a retrospective case series of 346 knees

While open wedge high tibial osteotomy (owHTO) is an established standard procedure to treat medial osteoarthritis of the knee in combination with varus deformity, it bears the risk of postoperative hardware f...

Authors: Claudia Hartz, Ralph Wischatta, Eckhardt Klostermeier, Malte Paetzold, Klaus Gerlach and Frank Pries

Tape suture for stabilization of incomplete posterior pelvic ring fractures—biomechanical analysis of a new minimally invasive treatment for incomplete lateral compression pelvic ring fractures

Incomplete lateral compression fractures (including AO Type B2.1) are among the most common pelvic ring injuries. Although the treatment of choice remains controversial, sacroiliac (SI) screws are commonly use...

Authors: Christopher Alexander Becker, Adrian Cavalcanti Kussmaul, Eduardo Manuel Suero, Markus Regauer, Matthias Woiczinski, Christian Braun, Wilhelm Flatz, Oliver Pieske, Christian Kammerlander, Wolfgang Boecker and Axel Greiner

Modern instant messaging platform for postoperative follow-up of patients after total joint arthroplasty may reduce re-admission rate

Follow-up after artificial joint replacement greatly helps achieve surgical outcomes. Mobile internet technology and mobile terminal equipment may increase the effectiveness of artificial joint replacement. Ho...

Authors: Qing-Yuan Zheng, Lei Geng, Ming Ni, Jing-Yang Sun, Peng Ren, Quan-Bo Ji, Jun-Cheng Li and Guo-Qiang Zhang

Rates of periprosthetic infection and surgical revision in Beijing (China) between 2014 and 2016: a retrospective multicenter cross-sectional study

Periprosthetic joint infection (PJI) is a rare but devastating complication after total joint arthroplasty. There is a paucity of data on the incidence and prevalence of periprosthetic infection in mainland Ch...

Authors: Hui-ming Peng, Long-chao Wang, Ji-ying Cheng, Yi-xin Zhou, Hua Tian, Jian-hao Lin, Wan-shou Guo, Yuan Lin, Tie-bing Qu, Ai Guo, Yong-ping Cao and Xi-sheng Weng

The BMP signaling pathway enhances the osteoblastic differentiation of bone marrow mesenchymal stem cells in rats with osteoporosis

This study was conducted with the aim of exploring the effect of the BMP signaling pathway on osteoblastic differentiation in rat bone marrow mesenchymal stem cells (rBMSCs) in rats with osteoporosis (OP).

Authors: Bin Zhao, Gengyan Xing and Aiyuan Wang

Anterior percutaneous full-endoscopic transcorporeal decompression of the spinal cord for single-segment cervical spondylotic myelopathy: The technical interpretation and 2 years of clinical follow-up

ACDF is the standard procedure for treatment of cervical spondylotic myelopathy (CSM), but a long-term follow-up has been revealed some associated complications of swallowing discomfort, displacement of the fu...

Authors: Weijun Kong, Zhijun Xin, Qian Du, Guangru Cao and Wenbo Liao

Correction to: Arthroscopic treatment of focal osteochondral lesions of the first metatarsophalangeal joint

This article [2] was published twice [1] due to a production error. The original article [1] should be considered the version of record and used for citation purposes. The publisher apologizes to the authors a...

Authors: Ersin Kuyucu, Harun Mutlu, Serhat Mutlu, Baris Gülenç and Mehmet Erdil

Open reduction and compression with double Kirschner wires for the treatment of old bony mallet finger

The management of old bony mallet fingers is complicated. The aim of the study is to present a new method of open reduction and compression with double Kirschner wires (K-wires) in treating old bony mallet fin...

Authors: Junjun Tang, Kejian Wu, Jinchang Wang and Jian Zhang

Associations between serum calcium, 25(OH)D level and bone mineral density in older adults

Calcium and vitamin D play important roles in bone health as essential nutrients. We explored whether serum calcium, 25(OH)D were associated with bone mineral density (BMD) in older adults.

Authors: Minbo Liu, Xiaocong Yao and Zhongxin Zhu

Risk factors for refracture after plate removal for midshaft clavicle fracture after bone union

Open reduction and internal fixation (ORIF) with plates and screws is one of the treatment options for clavicle fractures. However, an additional operation for implant removal after union of the fracture is co...

Authors: Shang-Wen Tsai, Hsuan-Hsiao Ma, Fang-Wei Hsu, Te-Feng Arthur Chou, Kun-Hui Chen, Chao-Ching Chiang and Wei-Ming Chen

Minimally invasive percutaneous plate osteosynthesis versus intramedullary nail fixation for distal tibial fractures: a systematic review and meta-analysis

The treatment for distal tibial fractures remains controversial to date. Minimally invasive percutaneous plate osteosynthesis (MIPPO) and intramedullary nailing (IMN) are well-accepted and effective methods fo...

Authors: Bo Wang, Yang Zhao, Qian Wang, Bin Hu, Liang Sun, Cheng Ren, Zhong Li, Kun Zhang, Dingjun Hao, Teng Ma and Yao Lu

One-stage simultaneous hip-preserving surgeries for the management of bilateral femoral head osteonecrosis: a mean 7.0-year follow-up

A retrospective study was conducted to evaluate and compare the clinical and radiological outcomes of one-stage fibular impaction allografting and vascularized greater trochanter flap autografting for the trea...

Authors: Wenjun Feng, Pengcheng Ye, Shihao Ni, Peng Deng, Lu Lu, Jinlun Chen, Jianchun Zeng, Xinyu Qi, Jie Li, Ke Jie, Houran Cao, Zhijun Yue, Haitao Zhang and Yirong Zeng

The prototype BS-II for computer measurement of biomechanical characteristics of the human cadaverous lumbar spine

The new second-generation computer system BS-II (Bio-Spine-II) based on the National Instruments’ development environment has been designed and constructed for evaluating the stability of various surgical fixa...

Authors: Vladislav Janák, Luděk Bartoněk, Lumír Hrabálek, Jiří Keprt and Jiří Charamza

Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis

Synovial fluid proteins had been applied as diagnostic biomarkers for periprosthetic joint infection (PJI) in recent research papers. Thus, this meta-analysis aimed to estimate the diagnostic efficiency of syn...

Authors: Yisheng Chen, Xueran Kang, Jie Tao, Yunpeng Zhang, Chenting Ying and Weiwei Lin

Therapeutic effect of percutaneous kyphoplasty combined with anti-osteoporosis drug on postmenopausal women with osteoporotic vertebral compression fracture and analysis of postoperative bone cement leakage risk factors: a retrospective cohort study

The purpose of this study is to explore the therapeutic effect of percutaneous kyphoplasty (PKP) combined with anti-osteoporosis drug, zoledronic acid, on postmenopausal women with osteoporotic vertebral compr...

Authors: Shuaihao Huang, Xiaowen Zhu, Dan Xiao, Jianxiong Zhuang, Guoyan Liang, Changxiang Liang, Xiaoqing Zheng, Yuhong Ke and Yunbing Chang

Response to Letter to the Editor: Concerns on modeling postmenopausal osteoporosis in young female rats

Authors: Juan Marcelo Rosales Rocabado, Masaru Kaku, Kosuke Nozaki, Takako Ida, Megumi Kitami, Yujin Aoyagi and Katsumi Uoshima

Concerns on modeling postmenopausal osteoporosis on young female rats

Authors: Pavlos Lelovas and Ismene Dontas

Intramedullary nailing for pertrochanteric fractures of proximal femur: a consecutive series of 323 patients treated with two devices

Pertrochanteric fractures (PFs) frequently affect the lower limb of osteoporotic patients and represent an important cause of morbidity and mortality in the elderly. In this prospective randomized controlled t...

Authors: Pompeo Catania, Daniele Passaretti, Giorgio Montemurro, Simone Ripanti, Stefano Carbone, Vittorio Candela, Michele Carnovale, Stefano Gumina and Francecsco Pallotta

Artesunate prevents knee intraarticular adhesion via PRKR-like ER kinase (PERK) signal pathway

Intraarticular scar adhesion refers to a serious complication caused by knee surgery or trauma, leading to various sequelae (e.g., articular cartilage degeneration and knee joint stiffness). Artesunate (ART) h...

Authors: Hui Chen, Jin Tao, Jingcheng Wang and Lianqi Yan

Correction to: Total hip arthroplasty with modular stem for Crowe I and II developmental dysplasia of the hip

In the original publication of this article [1], an sentence needs to be added in the end of the caption of Figure 1 and Figure 3: cited in our previous study [18].

Authors: Xiangpeng Kong, Yunming Sun, Minzhi Yang, Yonggang Zhou, Jiying Chen, Wei Chai and Yan Wang

Design and evaluation of nano-hydroxyapatite/poly(vinyl alcohol) hydrogels coated with poly(lactic-co-glycolic acid)/nano-hydroxyapatite/poly(vinyl alcohol) scaffolds for cartilage repair

Poly(vinyl alcohol) (PVA) hydrogels have been widely used in synthetic cartilage materials. However, limitations of PVA hydrogels such as poor biomechanics and limited cell ingrowth remain challenges in this f...

Authors: Weiping Su, Yihe Hu, Min Zeng, Mingqing Li, Shaoru Lin, Yangying Zhou and Jie Xie

Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies

Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes ...

Authors: Feifan Lu, Pei Liu, Qidong Zhang, Weiguo Wang and Wanshou Guo

The appropriate hybrid surgical strategy in three-level cervical degenerative disc disease: a finite element analysis

The purpose of this FE study was to analyze the biomechanical characteristics of different HS strategies used in the treatment of three-level CDDD (one-level CDA and two-level ACDF).

Authors: Y. M. Xie, Y. C. Zheng, S. J. Qiu, K. Q. Gong and Y. Duan

Correlation analysis between the pulmonary function test and the radiological parameters of the main right thoracic curve in adolescent idiopathic scoliosis

Scoliosis causes thoracic deformities, and it is necessary to assess these changes in pulmonary function test (PFT). To determine how measurements of spinal and thoracic cage deformities are related to pulmona...

Authors: Yonggang Wang, Fengguang Yang, Dongmin Wang, Haiyan Zhao, Zhanjun Ma, Peifen Ma, Xuchang Hu, Shixiong Wang, Xuewen Kang and Bingren Gao

Osteogenic differentiation of follicular stem cells on nano-Saghez scaffold containing BMP2

Bone tissue is one of the tissues that are capable of self-regeneration. However, bone self-regeneration is defeated in the case of broad lesion of bone structure. Isolated stem cells from wisdom tooth follicl...

Authors: Hananeh Bayat, Hassan Shahabinejad, Mohammad Bayat, Sadegh Shirian, Abdolreza Mohamadnia, Mohammadreza Alijani, Arash Godarzi, Pegah Shojaei, Sahar Shojaei, Abolfazl Shevidi and Naghmeh Bahrami

Autologous bone marrow expanded mesenchymal stem cells in patellar tendinopathy: protocol for a phase I/II, single-centre, randomized with active control PRP, double-blinded clinical trial

Patellar tendon overuse injuries are common in athletes. Imaging may show a change in tissue structure with tendon thickening and disruption of the intratendinous substance. We wish to test the hypothesis that...

Authors: Gil Rodas, Robert Soler, Ramón Balius, Xavier Alomar, Xavier Peirau, Mercedes Alberca, Ana Sánchez, Javier García Sancho, Clementina Rodellar, Antonio Romero, Lorenzo Masci, Lluís Orozco and Nicola Maffulli

Gamma 3 U-Blade lag screws in patients with trochanteric femur fractures: are rotation control lag screws better than others?

Intramedullary hip nails may be classified as blades or screws depending on the type of lag screw used. Recently, a combination of lag screw types with a U-clip insertion has also been used. The purpose of thi...

Authors: Jehyun Yoo, Sangmin Kim, Junyoung Choi and Jihyo Hwang

Total cross-sectional area of the femoral neck nutrient foramina measured to assess arterial vascular beds in the femoral head

A detailed understanding of the blood supply to the femoral head is required to plan the surgery in the femoral neck and head area. However, information about the blood vessel networks in the femoral head is i...

Authors: Jiong Mei, Kun Quan, Hua Wang, Yahui Dai, Fangfang Zhang and Ming Ni

A new single nucleotide polymorphism affects the predisposition to thoracic ossification of the posterior longitudinal ligament

Thoracic ossification of the posterior longitudinal ligament (T-OPLL) is one of the common factors that cause thoracic spinal stenosis, which results in intractable myelopathy and radiculopathy. Our previous s...

Authors: Peng Wang, Ze Teng, Xiaoguang Liu, Xiao Liu, Chao Kong and Shibao Lu

Patient-specific instrumentation improved three-dimensional accuracy in total knee arthroplasty: a comparative radiographic analysis of 1257 total knee arthroplasties

The purpose of this study was to compare restoration of mechanical limb alignment and three-dimensional component-positioning between conventional and patient-specific instrumentation in total knee arthroplasty.

Authors: Leo Pauzenberger, Martin Munz, Georg Brandl, Julia K. Frank, Philipp R. Heuberer, Brenda Laky, Eva Schwameis and Werner Anderl

Angle of approach to the superior rotator cuff of arthroscopic instruments depends on the acromial morphology: an experimental study in 3D printed human shoulders

Portal placement is a key factor for the success of arthroscopic procedures, particularly in rotator cuff repair. We hypothesize that the acromial anatomy may strongly determine the position of the shoulder bo...

Authors: Menduri Hoessly, Samy Bouaicha, Thorsten Jentzsch and Dominik C. Meyer

The regulatory mechanism of p38/MAPK in the chondrogenic differentiation from bone marrow mesenchymal stem cells

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation and joint inflammation, in which growth factors are significantly involved. The extracellular signal-regulat...

Authors: Ning Ma, Xiao Teng, Qi Zheng and Peng Chen