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  1. Accumulating articles demonstrate that circular RNAs play pivotal functions in tumorigenesis. However, the working mechanism of circ_0136666 in osteosarcoma (OS) progression remains to be further clarified.

    Authors: Xiang Gao, Nanwei Xu, Kaisong Miao, Gao Huang and Yong Huang
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:421
  2. Hip labral tear (LT) causes various degrees of hip pain, for which there are few objective measures. Bone marrow oedema (BME), characterized by a diffuse, widely spreading change in the bone marrow, is observe...

    Authors: Tomohisa Koyama, Kensuke Fukushima, Kentaro Uchida, Yoshihisa Ohashi, Katsufumi Uchiyama, Naonobu Takahira and Masashi Takaso
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:420
  3. It is recorded in the Chinese Pharmacopoeia that deer antlers can be used to tonify the kidney and strengthen bone. Although numerous studies have demonstrated that deer antler has protective effects on the ki...

    Authors: Zhenwei Zhou, Tiancheng Wang, Yuyan Jia, Tingting Wang, Enjing Luo, Jinghong Zhong, Jingcheng Zhang, Jianyu Wang, Yuchi Wei, Daqing Zhao and Baojin Yao
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:419
  4. As an important mediator of intercellular interaction and formation of extracellular bone matrix, porous scaffolds are widely used for bone regeneration. Accumulating evidences demonstrate that microRNA are in...

    Authors: Li Deng, Shuang Lai, Liyuan Fan, Xinlun Li, Hao Huang and Yandong Mu
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:418
  5. Primary purpose of this study was to determine the validity and reliability of the OneStep smartphone application in healthy adults. Secondary purpose was to determine the feasibility of measuring gait dysfunc...

    Authors: Jesse C. Christensen, Ethan C. Stanley, Evan G. Oro, Hunter B. Carlson, Yuval Y. Naveh, Rotem Shalita and Levi S. Teitz
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:417
  6. Because the patients undergoing medial patellofemoral ligament reconstruction (MPFLr) combined with medial tibial tubercle transfer (TTT) procedure are usually young and active, the quality of life (QoL) is al...

    Authors: Kuo Hao, Ao Feng, Lingce Kong and Fei Wang
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:416
  7. The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. This systematic review updated the current evidence on MSCs augmentation for chondral pro...

    Authors: Migliorini Filippo, Mangiavini Laura, Giorgino Riccardo, Vismara Valeria, Jörg Eschweiler and Nicola Maffulli
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:415
  8. To develop a magnetic resonance imaging (MRI)-based radiomics predictive model for the identification of knee osteoarthritis (OA), based on the tibial and femoral subchondral bone, and compare with the trabecu...

    Authors: Zhihao Xue, Liao Wang, Qi Sun, Jia Xu, Ying Liu, Songtao Ai, Lichi Zhang and Chenglei Liu
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:414
  9. To investigate the effect of the dorsal nerve fascial island (DNFI) flap on repairing finger soft tissue defects at the distal segments.

    Authors: Xun Wang, Jingdan Lv, Shujiao Liu, Shuangyue Xu and Guoliang Yan
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:413
  10. The femoral anteversion angle is an important factor in performing surgery in the proximal part of the femur. Predicting the femoral anteversion angle based on the morphology of the proximal femur is clinicall...

    Authors: Masahiro Suzuki, Koichi Kinoshita, Tetsuya Sakamoto, Hajime Seo, Sakae Kinoshita, Ichiro Yoshimura and Takuaki Yamamoto
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:412
  11. Comparisons between various conservative managements of spastic equinus deformity in cerebral palsy demonstrated limited evidences, to evaluate the efficacy of conservative treatment among cerebral palsy child...

    Authors: Krongkaew Klaewkasikum, Tanyaporn Patathong, Patarawan Woratanarat, Thira Woratanarat, Kunlawat Thadanipon, Sasivimol Rattanasiri and Ammarin Thakkinstian
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:411
  12. Malunion and nonunion of vertically displaced pelvic fractures result in lower limb length discrepancies, claudication, and pain. There have been few previous reports of this type of corrective surgery for the...

    Authors: Yangxing Luo, Li He, Yue Li, Jie Xie, Song Gong, Qian Zhang, Enzhi Yin, Meiqi Gu and Chengla Yi
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:409
  13. The occurrence of nonunion after tibial fracture surgery is mainly related to insufficient blood supply. Therefore, anatomical study of the internal and external tibial artery is very important, but there is n...

    Authors: Hongyu Wang, Jiaming Wan, Kailong Geng, Xiangnan Zhang and Ruixing Hou
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:408
  14. Mobile-bearing unicompartmental knee arthroplasty (MB-UKA) is an effective treatment for anteromedial knee osteoarthritis. Meticulous intraoperative soft tissue balancing remains challenging yet consequential ...

    Authors: Shaokui Nan, Zheng Cao, Yue Song, Xiangpeng Kong, Haifeng Li and Wei Chai
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:407
  15. Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration, synovial inflammation, osteophytes, and subchondral osteosclerosis. This study investigated the effects of resveratrol (RE...

    Authors: ChuanCai Liang, Hengte Xing, ChenYu Wang, XiongFeng Xu, Yarong Hao and Bo Qiu
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:406
  16. The objective of present study was to investigate the therapeutic effects of high tibial osteotomy (HTO) combined with platelet-rich plasma (PRP) for severe knee osteoarthritis (KOA).

    Authors: Conglei Dong, Chao Zhao and Fei Wang
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:405
  17. Immune checkpoint protein (ICP), which is a central factor group of the immune system, has been reported to have a correlation between the degree of its expression and the prognosis of patients with malignant ...

    Authors: Yumi Matsuyama, Kunihiro Asanuma, Keisuke Yoshida, Tomohito Hagi, Takahiro Iino, Tomoki Nakamura and Akihiro Sudo
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:404
  18. The purpose of this study was to evaluate the reproducibility of planned component positioning including tibial rotational alignment in patient-specific instrumentation (PSI) for total knee arthroplasty (TKA).

    Authors: Masaichi Sotozawa, Ken Kumagai, Shunsuke Yamada, Shuntaro Nejima and Yutaka Inaba
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:403
  19. Osteoporosis (OP) patients complicated with type II diabetes mellitus (T2DM) has a higher fracture risk than the non-diabetic patients, and mesenchymal stem cells (MSCs) from T2DM patients also show a weaker o...

    Authors: Sheng-li Xia, Zi-yuan Ma, Bin Wang, Feng Gao, Sheng-yang Guo and Xu-han Chen
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:402
  20. Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease; cellular glutamine metabolism in fibroblast-like synoviocytes (FLSs) of RA was known to be essential for RA pathogenesis and progression. NEA...

    Authors: Mei Zhang, Ning Lu, Hong-Jun Li, Xiao-Yun Guo, Lu Lu and Ying Guo
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:401
  21. Osteoarthritis (OA) presents cartilage damage in addition to chronic inflammation. However, self-recovery of damaged cartilage in an inflammatory environment is not possible. Mesenchymal stem cells (MSCs) in t...

    Authors: Rong Chen, Xiangwei Li, Zhibo Sun, Junyi Yin, Xiaowei Hu, Jingwen Deng and Xinghui Liu
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:400
  22. Open reduction and plate fixation are the preferred treatment options for most distal humerus fractures in adults. However, it is often challenging for orthopedic surgeons because of the complex anatomy and th...

    Authors: Soo-Hong Han, Jin Sung Park, Jong Hun Baek, Segi Kim and Ki Hyeok Ku
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:399
  23. Cholesterol can trigger degenerative processes in the chondrocytes. The internal layer of the hip labral consists of cartilage-specific type II collagen-positive fibrocartilage. The purpose of this study was t...

    Authors: Fan Yang, Hong-Jie Huang, Zhu Zhang, Xin Zhang and Jian-Quan Wang
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:398
  24. Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used as an alternative bone graft in spine fusion surgery. However, clinical outcome such as effects and complications has not yet been ...

    Authors: Jun-Young Choi, Hyun-Jin Park, Sang-Min Park, Chang-Nam Kang and Kwang-Sup Song
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:397
  25. Patient-Reported Outcomes Measurement Information System (PROMIS) domains for sleep disturbance, anxiety, and dyspnea have been under-reported for total joint arthroplasty (TJA). The aims of this study were to...

    Authors: Steven Z. George, Michael P. Bolognesi, Sean P. Ryan and Maggie E. Horn
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:396
  26. We aimed to compare the postoperative clinical efficacy and safety of medial pivot (MP) prosthesis and posterior-stabilized (PS) prosthesis in the treatment of knee osteoarthritis (KOA).

    Authors: Weipeng Shi, Yaping Jiang, Yingzhen Wang, Xuan Zhao, Tengbo Yu and Tao Li
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:395
  27. The etiology of ischiofemoral impingement (IFI) syndrome, an unusual and uncommon form of hip pain, remains uncertain. Some patients demonstrate narrowing of the space between the ischial tuberosity and lesser...

    Authors: Madhan Jeyaraman, Jayanth Murugan, Nicola Maffulli, Naveen Jeyaraman, Anish G. Potty and Ashim Gupta
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:393
  28. Total hip arthroplasty is a common orthopedic surgery for treating primary or secondary hip osteoarthritis. Bilateral total hip replacement could be performed in a single stage or two separate stages. Each sur...

    Authors: Akam Ramezani, Amirhossein Ghaseminejad Raeini, Amirmohammad Sharafi, Mehrdad Sheikhvatan, Seyed Mohammad Javad Mortazavi and Seyyed Hossein Shafiei
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:392
  29. There is still much controversy about whether transforaminal or interlaminar fully endoscopic spine surgery can better treat lumbar 4/5 disc herniation. Therefore, this study intends to compare the clinical ef...

    Authors: Quanlai Zhao, Liang Xiao, Zhongxuan Wu, Chen Liu and Yu Zhang
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:391
  30. Posterior minimally invasive surgery has been increasingly used in in recent years for the clinical treatment of cervical spondylosis. However, this treatment remains challenging and has not been comprehensive...

    Authors: Junqiao Lv, Jun Mei, Xiaoning Feng, Xuefeng Tian and Lin Sun
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:389
  31. Pyogenic vertebral osteomyelitis (PVO), which is a potentially life-threatening condition and is associated with significant morbidity and mortality, is a cause of back pain that can lead to neurologic deficit...

    Authors: Hong-Qi Zhang, Yu-Xiang Wang, Chao-feng Guo, Ming-xing Tang, Shao-hua Liu, Ang Deng and Qile Gao
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:388
  32. Several studies have suggested that the addition of iPACK block (the popliteal artery and the posterior knee capsule have been given interspace local anesthetic infiltration) might get better analgesia than ad...

    Authors: Jiao Guo, Minna Hou, Gaixia Shi, Ning Bai and Miao Huo
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:387
  33. Bridging bone defects in revision total hip arthroplasty is a challenge to orthopedic surgeons. The eccentric revision cup is a progression of jumbo cup. Our aim is to confirm the optimal screw-hole positions ...

    Authors: Yanchao Zhang, Haiyang Ma, Yang Liu, Junmin Shen, Bohan Zhang and Yonggang Zhou
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:386
  34. In this study, we investigated the potential acceleration of fracture healing and bone mineral density-increasing effects of romosozumab and active vitamin D3 combination therapy for fractures in ovariectomized r...

    Authors: Ryota Takase, Yuta Tsubouchi, Takefumi Otsu, Takashi Kataoka, Tatsuya Iwasaki, Masashi Kataoka and Hiroshi Tsumura
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:384
  35. In this letter to the editor, we discuss the article by Bigdon et al., published recently in the Journal of Orthopaedic Surgery and Research, about their accurate single-centre cohort study of 8000 vertebral frac...

    Authors: Dietrich Doll and Markus M. Luedi
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:382
  36. Insufficient pain control after lower limb arthroplasty results in delayed recovery and increased risk for pain chronicization. The ideal kind of analgesia is still discussed controversially. We conducted a re...

    Authors: Alina Yurutkina, Sven Klaschik, Pascal Kowark, Annette Gass, Carolina Link, Thomas Martin Randau, Jorge Jiménez-Cruz, Mark Coburn and Tobias Hilbert
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:381
  37. To investigate the effect of the degree of displacement of a femoral shaft fracture with the third fragment on fracture healing after intramedullary nailing.

    Authors: Shuo Yang, Yelin Yang, Yongfeng Huo, Jian Yu, Luxin Sheng, Xiao Sun, Xinhui Liu, Jian Yin and Zhaoyang Yin
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:380
  38. To determine the rates and risk factors of pedicle screw placement accuracy and the proximal facet joint violation (FJV) using TINAVI robot-assisted technique.

    Authors: Ren-Jie Zhang, Lu-Ping Zhou, Lai Zhang, Hua-Qing Zhang, Jian-Xiang Zhang and Cai-Liang Shen
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:379
  39. Coronal alignment after total knee arthroplasty (TKA) would influence the implant survival. Coronal alignment could be measured on short and full-length X-rays. The goal of the current study was to assess the ...

    Authors: Seyyed-Morteza Kazemi, Seyyed-Mohammad Qoreishi, Arash Maleki, Reza Minaei-Noshahr and Seyyed-Mohsen Hosseininejad
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:378
  40. The aim of this study was to analyze the clinical characteristics of older fracture patients with chronic kidney disease (CKD) and to determine the risk factors of perioperative cardiovascular complications.

    Authors: Yao Meng, Mingming Fu, Junfei Guo, Zhiqian Wang, Yingze Zhang and Zhiyong Hou
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:377
  41. Physiological saline (0.9% NaCl) and acetone are extensively used for storage (as well as hydration) and removal of bone marrow, respectively, of cancellous bone during preparation and mechanical testing. Our ...

    Authors: Fangxing Wang, Florian Metzner, Leyu Zheng, Georg Osterhoff and Stefan Schleifenbaum
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:376
  42. The risk of perioperative complications remains high in patients with intertrochanteric fractures. Immobilization after injury may predispose these patients to deep vein thrombosis (DVT) while waiting for surg...

    Authors: Kai Song, Bowen Zhu, Yao Yao, Qing Jiang, Jin Xiong and Hongfei Shi
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:375
  43. To investigate differences in the effectiveness of two lag screws, a regular bone plate, and locking bone plate fixation in treating horizontal oblique metacarpal shaft fractures.

    Authors: Yung-Cheng Chiu, Cheng-En Hsu, Tsung-Yu Ho, Yen-Nien Ting, Ming-Tzu Tsai and Jui-Ting Hsu
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:374
  44. For olecranon fractures, the choice of tension band wire (TBW) or plate fixation has long been controversial. Therefore, this study aimed to evaluate the efficacy and safety of TBW and plate in the treatment o...

    Authors: Yizhen Jia, Aifeng Liu, Tianci Guo, Jixin Chen, Weijie Yu and Jingbo Zhai
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:373
  45. The length of hospital stay after lower limb arthroplasty has rapidly decreased in the last decade, largely in part due to the rise of improved perioperative protocols, but also as a response to the increased ...

    Authors: Larissa Sattler, Luke Kisaloff, Taiyler Cragnolini, Radd Peters and Wayne Hing
    Citation: Journal of Orthopaedic Surgery and Research 2022 17:372

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