Articles

Comparison of lateral entry and crossed entry pinning for pediatric supracondylar humeral fractures: a meta-analysis of randomized controlled trials

Closed reduction and pinning entry fixation have been proposed as treatment strategies for displaced supracondylar humeral fractures (SCHFs) in children. However, controversy exists regarding the selection of ...

Authors: Huaguo Zhao, Song Xu, Guanyi Liu, Jingyu Zhao, Shandong Wu and Linrui Peng

Fracture of the inferior pole of the patella: tension band wiring versus transosseous reattachment

The optimal surgical technique for the fixation of inferior pole patellar fracture remains controversial. The aims of this study were (1) to compare clinical and radiological outcomes following fixation of inf...

Authors: Chih-Hsun Chang, Hao-Chun Chuang, Wei-Ren Su, Fa-Chuan Kuan, Chih-Kai Hong and Kai-Lan Hsu

NDRG1 regulates osteosarcoma cells via mediating the mitochondrial function and CSCs differentiation

Cancer stem cells (CSCs) are mainly contributed to malignancy metastatic potential and resistant therapy of osteosarcoma (OS). The mitochondria-related apoptosis was generally accepted as the target of tumor t...

Authors: Tong Zhao, Ying Meng, Yongping Wang and Wenji Wang

Accuracy of institutional orthopedic trauma databases: a retrospective chart review

Academic trauma institutions rely on fracture databases as research and quality control tools. Frequently, these databases are populated by trainees, but the completeness and accuracy of such databases has not...

Authors: Aman Chopra, Abigail C. Cortez, Ashraf El Naga, Anthony Ding and Saam Morshed

The effect of aqueous extract of Prunus dulcis on tibial bone healing in the rabbit

Bone fractures are medical emergencies that require prompt intervention to help return bone to its normal function. Various methods and treatments have been utilized to increase the speed and efficiency of bon...

Authors: Nima Anaraki, Amir Hossein Beyraghi, Abbas Raisi, Farshid Davoodi, Ghasem Farjanikish and Amin Bigham Sadegh

First metatarsophalangeal fusion with dorsal plate: clinical outcomes

First metatarsophalangeal joint (MTPJ) fusion is the most effective technique for the treatment of MTPJ primary arthritis, severe hallux valgus and failure of primary corrective surgery of these conditions. It...

Authors: Giuseppe Restuccia, Fabio Cosseddu, Andrea del Chiaro, Matteo Ceccoli, Alessandro Lippi and Sheila Shytaj

Perioperative red blood cell infusion and deep vein thrombosis in patients with femoral and pelvic fractures: a propensity score matching

The relationship between perioperative red blood cell (RBC) infusion and deep vein thrombosis (DVT) has not been determined.

Authors: Linqin Wu and Bo Cheng

Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study ai...

Authors: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang and Aijiao Ding

The short-term effectiveness and safety of second-generation patellofemoral arthroplasty and total knee arthroplasty on isolated patellofemoral osteoarthritis: a systematic review and meta-analysis

We aimed to compare second-generation patellofemoral arthroplasty (2G PFA) with total knee arthroplasty (TKA) in treating isolated patellofemoral osteoarthritis (PFOA) by assessing the percentages of revisions...

Authors: Chengxin Li, Zhizhuo Li, Lijun Shi, Fuqiang Gao and Wei Sun

Percutaneous periarticular analgesic injection at one day after simultaneous bilateral total knee arthroplasty: an open-label randomized control trial

The postoperative pain after total knee arthroplasty (TKA) remains a critical issue. The aim of this study was to assess the clinical effectiveness of percutaneous periarticular injection at 1 day following si...

Authors: Takuya Iseki, Sachiyuki Tsukada, Motohiro Wakui, Kenji Kurosaka, Shinichi Yoshiya and Toshiya Tachibana

The effect of care transition pathway implementation on patients undergoing joint replacement during the COVID-19 pandemic: a quasi-experimental study from a tertiary care hospital orthopedic department in Beijing, China

The coronavirus disease (COVID-19) pandemic has had a massive impact on individuals globally. The Chinese government has formulated effective response measures, and medical personnel have been actively respond...

Authors: Ya-ping Xu, Pei-yu Zhao, Yi-tong Bai and Shuang Li

Incidence and missed diagnosis risk of occult posterior malleolar fractures associated with the tibial shaft fractures: a systematic review

Tibial shaft fractures (TSFs) combined with occult posterior malleolar fractures (PMFs) are becoming widely recognized in the field of orthopedics. The purpose of this study was to determine the clinical incid...

Authors: Zhongzheng Wang, Wei Chen, Yanbin Zhu, Siyu Tian, Kuo Zhao, Jialiang Guo, Zhiyong Hou, Qi Zhang and Yingze Zhang

Treadmill running induces remodeling of the infrapatellar fat pad in an intensity-dependent manner

To investigate the response of the infrapatellar fat pad (IFP) to running at different intensities and further explore the underlying mechanisms of these responses under different running-induced loadings.

Authors: Ni Zeng, Tao Liao, Xin-Yuan Chen, Zhi-Peng Yan, Jie-Ting Li and Guo-Xin Ni

Measurement of operative femoral anteversion during cementless total hip arthroplasty and influencing factors for using neck-adjustable femoral stem

Placement of femoral stem in excessive anteversion or retroversion can cause reduced range of motion, prosthetic impingement, and dislocation. The aim of this study was to assess the operative femoral antevers...

Authors: Jingyang Sun, Bohan Zhang, Lei Geng, Qingyuan Zheng, Juncheng Li, Wenzhe Cao, Ming Ni and Guoqiang Zhang

Safety and efficacy of umbilical cord-derived Wharton’s jelly compared to hyaluronic acid and saline for knee osteoarthritis: study protocol for a randomized, controlled, single-blind, multi-center trial

Osteoarthritis (OA) is the most common joint disorder in the United States of America (USA) with a fast-rising prevalence. Current treatment modalities are limited, and total knee replacement surgeries have sh...

Authors: Ashim Gupta, Nicola Maffulli, Hugo C. Rodriguez, Eric W. Carson, Randa A. Bascharon, Kristin Delfino, Howard J. Levy and Saadiq F. El-Amin III

Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review

Biochemical markers of bone turnover (BTMs), such as the bone alkaline phosphatase (bALP), procollagen type I N propeptide (PINP), serum cross-linked C-telopeptides of type I collagen (bCTx), and urinary cross...

Authors: Filippo Migliorini, Nicola Maffulli, Filippo Spiezia, Giuseppe Maria Peretti, Markus Tingart and Riccardo Giorgino

Minimally invasive internal fixation for unstable pelvic ring fractures: a retrospective study of 27 cases

This study aimed to evaluate the radiographic and clinical outcomes of anterior subcutaneous internal fixation (INFIX) with or without posterior fixation for the treatment of unstable pelvic fractures.

Authors: Shuang Wu, Jialei Chen, Yun Yang, Wei Chen, Rong Luo and Yue Fang

Catastrophic failure and metallosis of the acetabular component in total hip arthroplasty

To evaluate the clinical features and results of the revision total hip arthroplasties (THA) in patients with catastrophic failures and metallosis.

Authors: Fırat Ozan, Murat Kahraman, Ali Baktır and Kürşat Gençer

Genes associated with inflammation and bone remodeling are highly expressed in the bone of patients with the early-stage cam-type femoroacetabular impingement

Recent studies have shown high expression levels of certain inflammatory, anabolic, and catabolic genes in the articular cartilage from the impingement zone of the hips with femoroacetabular impingement (FAI),...

Authors: Guanying Gao, Ruiqi Wu, Rongge Liu, Jianquan Wang, Yingfang Ao and Yan Xu

miR-520c-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GAS2

MicroRNAs (miRNAs) have been shown to be associated with osteoarthritis (OA) progression. This study aimed to explore the role of miR-520c-3p in OA progression.

Authors: Le Peng, Ming Deng, Yonggang Ma, Wei Hu and Fan Liang

Anatomical basis of the support of fibula to tibial plateau and its clinical significance

The fibula is only indirectly involved in the composition of the human knee joint and has therefore been neglected in the research on knee osteoarthritis. Nonuniform settlement of the proximal tibia plateau is...

Authors: Wen-Bin Jiang, Shi-Zhu Sun, Chan Li, Philip Adds, Wei Tang, Wei Chen, Sheng-Bo Yu and Hong-Jin Sui

Retraction Note: Comparison of bone morphogenetic protein and autologous grafting in the treatment of limb long bone nonunion: a systematic review and meta-analysis

Authors: Yong-Qiang Zhou, Hong-Liang Tu, Yan-Ji Duan and Xiao Chen

Evaluation of sleep disorder in orthopedic trauma patients: a retrospective analysis of 1129 cases

In the trauma center wards, it is not unusual for patients to have sleep disorders, especially patients with an acute injury. Meanwhile, there is substantial evidence that sleep disorder is a predictor of depr...

Authors: Hai Yang, Yi-jia Liu, Jia-lu Ye, Li-hong Zhao, Ling-li Li and Xiao-ling Hou

3D printing guide plate for accurate hemicortical bone tumor resection in metaphysis of distal femoral: a technical note

Surgical resection and reconstruction for low-grade bone sarcoma in the metaphysis of the distal femur remain challenging. We hypothesized that 3D printing osteotomy guide plate could assist to accurately rese...

Authors: Hongwei Wu, Shuo Yang, Jianfan Liu, Linqin Li, Yi Luo, Zixun Dai, Xin Wang, Xinyu Yao, Feng Zhou and Xian’an Li

Improvement of sleep quality 6 months after total knee arthroplasty: a systematic review and meta-analysis

Total knee arthroplasty (TKA) is an accepted, effective treatment to restore function, relieve pain, and improve the quality of life in patients with advanced osteoarthritis. One complication of this major sur...

Authors: Ali Alipourian, Negin Farhadian, Ehsan Zereshki and Habibollah Khazaie

Gastrocnemius muscle flap with vancomycin/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery

To investigate the clinical effect of gastrocnemius muscle flaps combined with vancomycin/gentamicin-calcium sulfate combined and autologous iliac bone graft in the phase I treatment of traumatic focal osteomy...

Authors: Weiwei Ruan, Menglu Li, Qiaofeng Guo and Bingyuan Lin

Radical treatment of severe open fractures of extremities by orthoplastic surgery: a 10-year retrospective study

This study aimed to retrospectively analyze clinical data of a series of patients with severe open fractures of extremities (Gustilo IIIb or IIIc), who achieved a satisfactory outcome through radical orthoplas...

Authors: Zhao Yang, Chao Xu, Yong-Gang Zhu, Jun Li, Zi-Xiang Wu, Ji-Wei Zou, Bao-Bao Xue, Dan-Min Miao, Lei Shang and Guang-Yue Zhao

Histological and ultrastructural degenerative findings in the gluteus medius tendon after hip arthroplasty

Despite gluteus medius (GMED) tendinosis being relatively common, its presence in association with hip osteoarthritis (OA) or total hip arthroplasty (THA) is not well studied. It was hypothesized that more ten...

Authors: Mustafa Ibrahim, Urban Hedlundh, Ninni Sernert, Khaled Meknas, Lars Haag, Tomas Movin, Nikos Papadogiannakis and Jüri-Toomas Kartus

Association of acute inflammatory cytokines, fracture malreduction, and functional outcome 12 months after intra-articular ankle fracture—a prospective cohort study of 46 patients with ankle fractures

Several malreduction criteria have been proposed for ankle surgery, but the criteria of most importance for functional outcome remain undetermined. Furthermore, the acute inflammatory response in the ankle joi...

Authors: That Minh Pham, Emil Bjoertomt Kristiansen, Lars Henrik Frich, Kate Lykke Lambertsen, Søren Overgaard and Hagen Schmal

Age at surgery is correlated with pain scores following trochlear osteotomy in lateral patellar instability: a cross-sectional study of 113 cases

A trochlear osteotomy aims to restore patellar stability in patients with recurrent patellar instability and trochlear dysplasia. The age of patients at time of surgery could be a relevant factor which influen...

Authors: Jordy D. P. van Sambeeck, Nico Verdonschot, Albert Van Kampen and Sebastiaan A. W. van de Groes

COVID-19 among patients with orthopedic surgery: our experience from the Middle East

We report our experiences with COVID-19 in one of the largest referral orthopedic centers in the Middle East and aimed to describe the epidemiology and clinical characteristics of these patients.

Authors: Abolfazl Bagherifard, Peyman Arasteh, Mostafa Salehpour, Hooman Shariat Zadeh, Farid Najd Mazhar, Hasan Ghandhari, Mohammad Reza Bahaeddini, Pouria Tabrizian and Alireza Askari

Hip geometry in hip fracture patients in Greenland occurring over a 7.7-year period

Hip geometry influences hip fracture risk. Hip fractures are common, and they are associated with pain, disability, premature death and marked costs on society. Osteoporotic fractures are frequent in Arctic po...

Authors: Inuuteq Fleischer, Mogens Laursen and Stig Andersen

Neohesperidin promotes the osteogenic differentiation of bone mesenchymal stem cells by activating the Wnt/β-catenin signaling pathway

Osteoporosis is a common disease in aging populations. However, osteoporosis treatment is still challenging. Here, we aimed to investigate the role of neohesperidin (NEO) in osteoporosis progression and the po...

Authors: Yue-wen Chang, Wen-jun Zhu, Wei Gu, Jun Sun, Zhi-qiang Li and Xiao-en Wei

Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study

Studies evaluating the role of both corticosteroids and platelet-rich plasma (PRP) in the treatment of rotator cuff (RC) tendinopathies have been contradicting.

Authors: Haleh Dadgostar, Farinaz Fahimipour, Alireza Pahlevan Sabagh, Peyman Arasteh and Mohammad Razi

Prediction of the risk of C5 palsy after posterior laminectomy and fusion with cervical myelopathy using a support vector machine: an analysis of 184 consecutive patients

This study aimed to predict C5 palsy (C5P) after posterior laminectomy and fusion (PLF) with cervical myelopathy (CM) from routinely available variables using a support vector machine (SVM) method.

Authors: Haosheng Wang, Zhi-Ri Tang, Wenle Li, Tingting Fan, Jianwu Zhao, Mingyang Kang, Rongpeng Dong and Yang Qu

Correction to: The long pentraxin PTX3: a novel serum marker to improve the prediction of osteoporosis and osteoarthritis bonerelated phenotypes

Authors: Virginia Veronica Visconti, Chiara Greggi, Simona Fittipaldi, Donato Casamassima, Mariagrazia Tallarico, Francesco Romano, Annalisa Botta and Umberto Tarantino

The effects of posterior cruciate ligament rupture on the biomechanical and histological characteristics of the medial collateral ligament: an animal study

To investigate the effect of complete rupture of the posterior cruciate ligament (PCL) on the biomechanics and histology of the medial collateral ligament (MCL).

Authors: Wen-qing Xie, Miao He, Yu-qiong He, Deng-jie Yu, Hong-fu Jin, Fang Yu and Yu-sheng Li

A new prediction model for patient satisfaction after total knee arthroplasty and the roles of different scoring systems: a retrospective cohort study

Although total knee arthroplasty (TKA) is an efficacious treatment for end-stage osteoarthritis, ~20% of patients are dissatisfied with the results. We determined which factors contribute to patient satisfacti...

Authors: Jinyu Liu, Yi Yang, Shengcheng Wan, Zhenjun Yao, Ying Zhang, Yueqi Zhang, Peng Shi and Chi Zhang

Letter to the Editor regarding “Hemiarthroplasty compared to total hip arthroplasty for the treatment of femoral neck fractures: a systematic review and meta-analysis”

Authors: Qiujiang Li, Xingxia Long, Yinbin Wang, Xiaocheng Jiang and Lijun Cai

Bioinformatics analysis and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head

Steroid-induced osteonecrosis of the femoral head (ONFH) is a common hip joint disease and is difficult to be diagnosed early. At present, the pathogenesis of steroid-induced ONFH remains unclear, and recogniz...

Authors: Tianye Lin, Weijian Chen, Peng Yang, Ziqi Li, Qiushi Wei, Du Liang, Haibin Wang, Wei He and Qingwen Zhang

A novel “three-dimensional-printed individual guide template-assisted percutaneous vertebroplasty” for osteoporotic vertebral compression fracture: a prospective, controlled study

Conventional percutaneous vertebroplasty (PVP) are mainly guided by C-arm fluoroscopy, and it usually leads to excessive X-ray radiation exposure to patients, surgeons, and anesthetists. Moreover, multi-time f...

Authors: Pei Lun Hu, Ji Sheng Lin, Hai Meng, Nan Su, Yong Yang and Qi Fei

Attenuated serum vasoactive intestinal peptide concentrations are correlated with disease severity of non-traumatic osteonecrosis of femoral head

The neuropeptide vasoactive intestinal peptide is a 28-amino acid neuropeptide that has been shown to stimulate bone repair and angiogenesis. The purpose of this study was to explore the potential role of seru...

Authors: Ming Liu, Gan Zhao and Biao-Fang Wei

Comparison of short-term outcomes between direct anterior approach (DAA) and SuperPATH in total hip replacement: a systematic review and network meta-analysis of randomized controlled trials

Two minimally invasive approaches showed some advantages in outcomes compared to conventional approaches (CAs)—the direct anterior approach (DAA) and the supercapsular percutaneously assisted approach in THA (...

Authors: Nikolai Ramadanov, Simon Bueschges, Kuiliang Liu, Philip Lazaru and Ivan Marintschev

Validation of the cultural adaptation of the Kujala score in Arabic

Patellofemoral pain is a common condition. The Kujala score is a well-established scoring system to assess anterior knee pain and has been translated into many languages including Arabic. The purpose of this c...

Authors: Bassem I. Haddad, Mohammad Hamdan, Ula Isleem, Munther Ghassan Al-Saber, Fadi A. Al-Hadidi, Saif Aldeen AlRyalat and Fatima Alnaimat

Ultrasound-guided surgery for lateral snapping hip: a novel ultraminimally invasive surgical technique

Greater trochanteric pain syndrome encompasses a range of causes of lateral hip pain including greater trochanteric bursitis, tendinopathy and tears of the gluteus minimus and medius, and lateral snapping hip ...

Authors: Manuel Villanueva, Álvaro Iborra, Pablo Sanz-Ruiz and Concepción Noriega

The effect of SOX4 gene 3′UTR polymorphisms on osteoporosis

This study aimed to explore the correlation between the SRY-related high-mobility-group box gene 4 (SOX4) 3′ untranslated region (UTR) single nucleotide polymorphism (SNP) and osteoporosis susceptibility.

Authors: Guo Li, Zuchao Gu, Yue He, Chongwen Wang and JiQiang Duan

Association between intravenous iron therapy and short-term mortality risk in older patients undergoing hip fracture surgery: an observational study

Anemia is common among ortho-geriatric hip fracture patients and is associated with prolonged recovery and increased postoperative mortality rate. Intravenous iron seems to increase hemoglobin recovery and red...

Authors: Silas Zacharias Clemmensen, Kristian H. Kragholm, Dorte Melgaard, Lene T. Hansen, Johannes Riis, Christian Cavallius, Marianne M. Mørch and Maria Lukács Krogager

The change of coagulation profile in two-staged arthroplasty for periprosthetic joint infection patients: a retrospective cohort study

Periprosthetic joint infection (PJI) is a serious complication of total joint arthroplasty. We performed a retrospective cohort study to evaluate (1) the change of coagulation profile in two-staged arthroplast...

Authors: Hao Li, Rui Li, L. L. Li, Wei Chai, Chi Xu and Jiying Chen

Biomarkers as therapy monitoring for postmenopausal osteoporosis: a systematic review

Biochemical markers of bone turnover (BTMs), such as bone alkaline phosphatase (bALP), procollagen type I N propeptide (PINP), serum cross-linked C-telopeptides of type I collagen (bCTx), and urinary cross-lin...

Authors: Filippo Migliorini, Nicola Maffulli, Filippo Spiezia, Markus Tingart, Peretti Giuseppe Maria and Giorgino Riccardo

Medium term outcome of Lancaster cortical window technique for extraction of femoral stem in revision hip arthroplasty

The extraction of a femoral stem during the revision hip arthroplasty can be a daunting task and can lead to catastrophic complications for the patient. A sound technique employed intraoperatively helps in the...

Authors: Amit Singh, Sunirmal Mukherjee, Kuntal Patel, Deepak Herlekar, Srikant Gandavaram and Nicholas Charalambous