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  1. The rapid progressive cervical spondylotic myelopathy (rp-CSM) which had a course of CSM less than 1 month and suffered rapidly progressive neurological deterioration had few reports. Therefore, it is importan...

    Authors: Weiyang Zhong, Lin Wang, Tianji Huang and Xiaoji Luo

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:75

    Content type: Research article

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  2. Mandibular fracture healing is a complex process involving nerves and growth factors. Nerve growth factor (NGF) not only facilitates the maintenance of sympathetic neurite growth but also stimulates other grow...

    Authors: Sen Yang, Jiao Cheng, Cheng Man, Lian Jiang, Guogeng Long, Wenjun Zhao and Dexin Zheng

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:74

    Content type: Research article

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  3. Percutaneous vertebroplasty (PVP) is a routine operation for the treatment of osteoporotic lumbar compression fractures (OLCFs). As is well known, unilateral puncture is a common method. However, with the conv...

    Authors: Wenwu Zhang, Shenpeng Liu, Xianhua Liu, Xiang Li, Le Wang and Yong Wan

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:73

    Content type: Research article

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  4. Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling ...

    Authors: Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa and Haruhiko Tokuda

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:72

    Content type: Research article

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  5. Bone neoplasms present poor prognosis due to recurrence and metastasis. Although the role microRNAs (miRNAs) in inhibiting growth and metastasis of bone neoplasms has been investigated, the underlying potentia...

    Authors: Yang Li, Xiaotao Long, Ji Wang, Jing Peng and Kai Shen

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:71

    Content type: Research article

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  6. To retrospectively analyze the clinical efficacy of PFNA combined with a cerclage wire in the treatment of 52 patients with unstable subtrochanteric fracture of the femur and to analyze the biomechanical effec...

    Authors: Xiaowei Huang, Fangxue Zhang and Yong Zhang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:70

    Content type: Research article

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  7. This study was performed to compare the advantage and disadvantage of posterolateral approach (PLA) and direct anterior approach (DAA) in total hip arthroplasty (THA).

    Authors: Xuedong Sun, Xueli Zhao, Licheng Zhou and Zheng Su

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:69

    Content type: Systematic review

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  8. Osteoarthritis (OA) is a leading cause of disability. The incidence of OA is progressively rising due to the diminishing levels of physical activity and ever-expanding aging population. However, the mainstay f...

    Authors: Zhenxing Si, Shifeng Zhou, Zilong Shen, Feiyu Luan and Jinglong Yan

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:68

    Content type: Research article

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  9. Short tapered stem placement has been extensively employed in total hip arthroplasty (THA). Suboptimal fixation tends to cause postoperative complications, such as thigh pain. However, it remains unclear wheth...

    Authors: Zhijie Chen, Bin Li, Kaizhe Chen, Jianmin Feng, Yi Wang, Zhihong Liu and Chuan He

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:67

    Content type: Research article

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  10. The purpose of this study was to investigate the correction error associated with soft tissue balance in high tibial osteotomy (HTO) and the difference between opening wedge HTO (OWHTO) and closed wedge HTO (C...

    Authors: Ken Kumagai, Hiroshi Fujimaki, Shunsuke Yamada, Shuntaro Nejima, Joji Matsubara and Yutaka Inaba

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:66

    Content type: Research article

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  11. Percutaneous kyphoplasty is the main method in the treatment of thoracolumbar osteoporotic compression fractures. However, much radiation exposure during the operation harms the health of surgeons and patients...

    Authors: Boyao Wang, Jiang Cao, Jie Chang, Guoyong Yin, Weihua Cai, Qingqing Li, Zhenfei Huang, Lipeng Yu and Xiaojian Cao

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:65

    Content type: Research article

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  12. Knowledge regarding the pathogenesis of osteoarthritis (OA) is very limited. Previous studies have shown that matrix metalloproteinase (MMP) 8 and MMP9 were upregulated in patients with diabetic OA. However, t...

    Authors: Simin Luo, Wuji Li, Wenrui Wu and Qiping Shi

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:64

    Content type: Research article

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  13. Osteoarthritis (OA) is a chronic degenerative joint disease and the most frequent type of arthritis. This study aimed to identify the key miRNAs and genes associated with OA progression.

    Authors: Pei-yan Huang, Jun-guo Wu, Jun Gu, Tie-qi Zhang, Ling-feng Li, Si-qun Wang and Minghai Wang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:63

    Content type: Research article

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  14. Inequalities in leg length result in functional disorders, as they impair the biomechanics of the musculoskeletal system, significantly reducing the quality of life (QoL). This study used the WHOQoL-BREF quest...

    Authors: Łukasz Pawik, Malwina Pawik, Zdzisława Wrzosek, Felicja Fink-Lwow and Piotr Morasiewicz

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:62

    Content type: Research article

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  15. Persistent post-operative pain (PPOP) has detracted from some otherwise successful knee arthroplasties. This study investigated medial abrasion syndrome (MAS) as a cause of PPOP after knee arthroplasty. The su...

    Authors: Shaw-Ruey Lyu, Chia-Chen Hsu and Jung-Pin Hung

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:61

    Content type: Research article

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  16. Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress and ...

    Authors: Jiajia Zhang, Ya-nan Wang, Tingting Jia, Haiyun Huang, Dongjiao Zhang and Xin Xu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:59

    Content type: Research article

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  17. Fractures of the base of the coracoid process are relatively rare, but an increasing number of studies have reported using screws to fix coracoid process base fractures. This study was performed to simulate th...

    Authors: Zhongye Sun, Hao Li, Bei Wang, Jun Yan, Liren Han, Shizhang Han, Xiaofei Yang and Bei Zhao

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:58

    Content type: Research article

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  18. Recent work has shed light on the potential benefits of cannabinoids for multimodal pain control following orthopedic procedures. The objective of this review was to summarize the available evidence of analges...

    Authors: Bradley J. Vivace, Allyson N. Sanders, Steven D. Glassman, Leah Y. Carreon, Joseph L. Laratta and Jeffrey L. Gum

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:57

    Content type: Systematic review

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  19. Particulated juvenile allograft cartilage (PJAC) has a good short-term clinical efficacy in repairing articular cartilage defects, but the proliferation ability of PJAC and the biological characteristics of tr...

    Authors: Changgui Zhang, Xingyu Zhao, Yunong Ao, Jin Cao, Liu Yang and Xiaojun Duan

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:56

    Content type: Research article

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  20. Intervertebral disk degeneration (IDD) is a degenerative disease characterized by cytoplasm loss and extracellular matrix degradation. Numerous evidence reported that miRNAs participated in IDD development. Ne...

    Authors: Jianmin Xue, Baoyang Hu, Wenhua Xing, Feng Li, Zhi Huang, Wenkai Zheng, Bo Wang, Yong Zhu and Xuejun Yang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:55

    Content type: Research article

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  21. Femoral neck fractures are still unsolved problems nowadays; sliding hip screw (SHS) and cannulated compression screw (CCS) are the most commonly used devices. We evaluated the clinical outcomes and complicati...

    Authors: Yutong Xia, Wendong Zhang, Zhen Zhang, Jingcheng Wang and Lianqi Yan

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:54

    Content type: Systematic review

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  22. This study aimed to evaluate the efficacy and safety of using high-dose intravenous tranexamic acid (TXA) to reduce blood loss in idiopathic scoliosis surgery.

    Authors: Indra K. Shrestha, Tian-Yi Ruan, Lan Lin, Miao Tan, Xue-Qing Na, Qi-Cai Qu, Jian-Chun Chen, Yong-Yu Si and Jian-Ping Tao

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:53

    Content type: Research article

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  23. No large series have analysed distally based sural fasciocutaneous (DBSF) flaps in paediatric patients. The aims of this study were to assess the reliability and analyse the potential risk factors for these fl...

    Authors: Zhaobiao Luo, Jiangdong Ni, Guohua Lv, Jianwei Wei, Lihong Liu, Ping Peng and Zhonggen Dong

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:52

    Content type: Research article

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  24. Osseointegration is the premise of the chewing function of dental implant. Nerve growth factor (NGF), as a neurotrophic factor, can induce bone healing. However, the influence of NGF-chondroitin sulfate (CS)/h...

    Authors: Jun Ye, Bo Huang and Ping Gong

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:51

    Content type: Research article

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  25. Circular RNAs (circRNAs) have been shown to participate in the chemoresistance and tumorigenesis of multiple cancers. The purpose of this research was to investigate the function of circ_0081001 in methotrexat...

    Authors: Wei Wei, Liefeng Ji, Wanli Duan and Jiang Zhu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:50

    Content type: Research article

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  26. To study the impact of changes in spino-cranial angle (SCA) on sagittal alignment and to investigate the relationship between SCA and Neck Disability Index (NDI) scores after laminoplasty (LP)

    Authors: Zheng Wang, Zhi-Wei Wang, Xi-Wen Fan, Zhen Liu, Jia-Yuan Sun, Wen-Yuan Ding and Da-Long Yang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:49

    Content type: Research article

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  27. The use of cephalo-medullary nails (CMN) is a widely accepted management option for the treatment of unstable per-trochanteric hip fractures. A growing body of literature has reported good functional and radio...

    Authors: Amr Selim, Nikhil Ponugoti, Ali Zain Naqvi and Henry Magill

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:47

    Content type: Systematic review

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  28. Most of the studies assessing the corrective posterior total hip arthroplasty (THA) mainly focused on the mini-incision approach. Studies exploring the short external rotator sparing approach are rare. Therefo...

    Authors: Tianbao Wang, Yongwei Zhou, Xiaofei Li, Siqi Gao and Qining Yang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:46

    Content type: Research article

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  29. Hip surgeons performing total hip arthroplasty (THA) through the direct anterior approach (DAA) commonly use a traction table to facilitate exposure. Even though performing THA through DAA without a traction t...

    Authors: Diane Wernly, Julien Wegrzyn, Geoffroi Lallemand, Jaad Mahlouly, Christophe Tissot and Alexander Antoniadis

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:45

    Content type: Research article

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  30. Rheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a substantial burden for both patients and society. Early diagnosis of RA is essential to prevent disease progression and select an opt...

    Authors: Jianyong Liu and Ningjie Chen

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:44

    Content type: Research article

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  31. Mesenchymal stem cells (MSCs) are used for the treatment of osteoarthritis (OA), and MSC genetic engineering is expected to enhance cartilage repair. Here, we aimed to investigate the effect of MSCs overexpres...

    Authors: Jiwon Oh, Yeon Sung Son, Wan Hee Kim, Oh-Kyeong Kwon and Byung-Jae Kang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:43

    Content type: Research article

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  32. The combination of endovascular intervention and microvascular free flap transfer has been effectively used for chronic ischemic wounds of lower limb. The aim of this study was to determine the influence of an...

    Authors: Duy Quang Thai, Dong Hwan Lee, Woo Beom Lee, Hyung Min Hahn and Il Jae Lee

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:42

    Content type: Research article

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  33. Anterior-posterior compression (APC) type II pelvis fracture is caused by the destruction of pelvic ligaments. This study aims to explore ligaments injury in APC type II pelvic injury.

    Authors: Jianzhong Kong, Yupeng Chu, Chengwei Zhou, Shuaibo Sun, Guodong Bao, Yu Xu, Xiaoshan Guo and Xiaolong Shui

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:41

    Content type: Research article

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  34. Knee osteoarthritis (KOA) seriously affects the quality of life of KOA patients. This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by cho...

    Authors: Jiatian Qian, Peiliang Fu, Shiao Li, Xiang Li, Yancheng Chen and Zhenen Lin

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:40

    Content type: Research article

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  35. The aim of this study was to determine the risk factors and develop a nomogram for blood transfusions after posterior lumbar spinal fusion (PSL).

    Authors: Haosheng Wang, Kai Wang, Bin Lv, Haotian Xu, Weibo Jiang, Jianwu Zhao, Mingyang Kang, Rongpeng Dong and Yang Qu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:39

    Content type: Research article

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  36. Osteoporosis (OP) is a complex bone metabolism disorder characterized by the loss of bone minerals and an increased risk of bone fracture. A recent study reported the relationship of the macrophage erythroblas...

    Authors: Xuan Cai, Jun Dong, Teng Lu, Liqiang Zhi and Xijing He

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:38

    Content type: Research article

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  37. Wrist tuberculosis is a rare disease, which is easy to be misdiagnosed, leading to delayed treatment and poor prognosis. In this study, the clinical manifestations, diagnosis, treatment, and prognosis of 18 ca...

    Authors: Longfei Zou, Xing Guo, Hao Xue, Denghua Huang, Hui Lv and Meiyun Tan

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:37

    Content type: Research article

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  38. To investigate the clinical outcomes of percutaneous cross screws internal fixation for pelvic Day type II crescent fracture-dislocation.

    Authors: Guangheng Xiang, Xiaoyu Dong, Xingan Jiang, Leyi Cai, Jianshun Wang, Xiaoshan Guo, Jian Xiao and Yongzeng Feng

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:36

    Content type: Research article

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  39. Whilst bony fixation of hip replacement has stable solutions, there remains controversy over which bearing best optimizes longevity and function. Ceramic-on-ceramic (CoC) bearing combinations are associated wi...

    Authors: Edward T. Davis, Ville Remes, Petri Virolainen, Peter Gebuhr, Bart Van Backlé, Matthew P. Revell and Branko Kopjar

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:35

    Content type: Research article

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  40. The K-line is a virtual straight line that connects the midpoints of the anteroposterior spinal canal diameter from C2 to C7 on a cervical lateral X-ray film. Patients with cervical ossification of the posteri...

    Authors: Yipeng Li, Jia Li, Feng Wang, Linfeng Wang and Yong Shen

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:34

    Content type: Research article

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  41. Inter-limb asymmetry above a certain threshold in functional performance indicates increased injury risk in sports. Fatigue has been found to increase bilateral asymmetry in lower-limb jumping performance amon...

    Authors: Yanfei Guan, Shannon Bredin, Qinxian Jiang, Jack Taunton, Yongfeng Li, Nana Wu, Lina Wu and Darren Warburton

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:33

    Content type: Research article

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  42. Evaluating of the articular cartilage status of the distal humeral epiphysis is difficult. Ultrasound imaging of the elbow is increasingly being used to confirm the integrity of the articular cartilage of mini...

    Authors: Xing Wu, Xiongtao Li, Shaowei Yang, Si Wang, Jingdong Xia, Xiaoliang Chen and Xiantao Shen

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:32

    Content type: Research article

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  43. Fibrinogen (FIB) has recently been used as a biomarker to diagnose periprosthetic joint infection (PJI), but its reliability is still questionable. The aim of this study was to investigate the accuracy of FIB ...

    Authors: Xingyang Zhu, Haitao Zhang, Xiaobo Sun, Yijin Li, Jiahao Li, Yuqing Zeng, Peng Deng, Xinyu Qi, Jinlun Chen, Pengcheng Ye, Wenjun Feng, Jie Li, Jianchun Zeng and Yirong Zeng

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:31

    Content type: Research article

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  44. D-dimer and fibrinogen, both belonging to coagulation parameters, are controversial for the diagnosis of periprosthetic joint infection (PJI). This meta-analysis was conducted to compare their diagnostic accur...

    Authors: Liping Pan, Hao Wu, Heng Liu, Xin Yang, Zhichao Meng and Yongping Cao

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:30

    Content type: Research article

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  45. The typical anterolateral approach is widely used to treat proximal humerus fractures with lateral locking fixation. However, lateral fixation cannot completely avoid medial reduction loss and varus deformity ...

    Authors: Fu Wang, Yan Wang, Jinye Dong, Yu He, Lianxin Li, Fanxiao Liu and Jinlei Dong

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:29

    Content type: Research article

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  46. The femoral component anteversion during surgery is traditionally assessed by a visual assessment of the surgeon and has proven to be imprecise. We sought to determine the accuracy of a digital protractor and ...

    Authors: Anuwat Pongkunakorn, Nawakun Phetpangnga and Narawit Kananai

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:27

    Content type: Research article

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  47. Developmental dysplasia of the hip (DDH) is a common disorder and associated with significant morbidity of the hip joint. Several risk factors have been identified for DDH. The aim of this study is to investig...

    Authors: Duran Topak, Muhammet Seyithanoğlu, Fatih Doğar, Ali Aydın Karadeniz, Burak Tanrıverdi, Fırat Ozan and Ökkeş Bilal

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:24

    Content type: Research article

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  48. Minimally invasive-transforaminal lumbar interbody fusions (MIS-TLIF), in which the nerve root pain is caused by early postoperative edema reaction, is a common clinical complication. However, there is no effe...

    Authors: Jinpeng Du, Junsong Yang, Liang Yan, Lequn Shan, Wentao Wang, Yong Fan, Dingjun Hao and Dageng Huang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:20

    Content type: Research article

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