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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: l-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway

Fig. 6

l-carnitine improved mitochondrial function and lipid accumulation through CPT1 to achieve anti-inflammatory effects in the KOA model of rats. a–c Real-time PCR data of TRPA1, IL-1β, and TNF-α. d–f Immunoblot analysis of TRPA1, IL-1β, and TNF-α. g TUNEL-positive cells are shown in KOA synovia (black arrows, × 200 magnification). h Immunoblot analysis of cyc was performed. i, j Detection of MDA content and SOD activity. Data are presented as the mean ± SD (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001

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