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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: l-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway

Fig. 5

l-carnitine-induced enhancement of CPT1 mediated by AMPK protects against synovitis in the synovial tissue of rats. a Immunohistochemistry shows that the l-carnitine group showed a significant upregulation of CPT1 compared with the ACLT group (positive cells are shown with blue arrows, × 200 magnification, n = 6). b Immunoblot and densitometric analysis of CPT1 (n = 3). c Real-time PCR analysis of CPT1 (n = 3). d CPT1 activity analysis in the serum (n = 3). e ELISA measurement of IL-1β, IL-6, and IL-10 levels in the serum (n = 6). Data are presented as the mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X