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Table 2 Summary of Certainty of Evidence Assessment for Each Outcome Using the PROfiler Grading System

From: Efficacy and safety of autologous platelet-rich plasma for diabetic foot ulcer healing: a systematic review and meta-analysis of randomized controlled trials

Outcome

Certainty of Evidence

Risk of Bias

Inconsistency

Indirectness

Imprecision

Publication Bias

Overall Healing Rate of DFU

High

Low

Moderate

Low

Low

Low

Time to Complete Wound Healing

Moderate

Moderate

High

Low

Moderate

Low

Ulcer Volume Reduction

High

Low

Low

Low

Low

Low

Amputation Rate

Moderate

Low

Low

Moderate

Low

Low

Adverse Events

Low

Moderate

Moderate

High

Moderate

Moderate