Table 1 Characteristics of studies included in the meta-analysis
Author | Year | Study design | Country | Total/PRP | Treatment strategy | Treatment strategy | Ulcer classification | PRP preparation | PRP application |
|---|---|---|---|---|---|---|---|---|---|
Tofigh | 2022 | RCT | Iran | 161/81 | PRP" | Control" | Wagner classification: I, II, III, IV, V | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | PRP gel applied on ulcer with Vaseline gauze, few layers of sterile gauze, and non-compressible bandage. This was repeated twice weekly |
Meamar | 2021 | RCT | Iran | 17/10 | PRP + SC | SC | Texas classification: IA, IIA, IC, IIC | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | PRP gel applied on ulcers after irrigation with 0.9% saline twice weekly covered with non-absorbing dressing |
Helmy | 2021 | RCT | Egypt | 80/40 | PRP + SC | SC | Wagner classification: I-IV | NC | PRP gel applied on ulcers covered with two pieces of dry sterile gauzes. PRP dressing was performed only once at the beginning of study |
Hossam | 2021 | RCT | Iran | 160/80 | PRP + SC | SC | Wagner classification: I, II, III, IV, V | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | PRP gel applied on ulcers covered with two pieces of dry sterile gauzes. PRP dressing was performed only once at the beginning of study |
Alamdari | 2021 | RCT | Iran | 90/43 | PRP + SC | SC | Ulcers that had exposed bone or bone, involvement were excluded | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | PRP gel applied on ulcers covered with Vaseline gauze and then a dressing. This was repeated twice weekly |
Habeeb | 2020 | RCT | Egypt | 44/22 | PRP + SC | SC | Wagner classification: I, II, III, IV, V | Peripheral blood was centrifuged at 2000 rpm A for 10 min | PRP gel applied on ulcers covered with vapor-permeable film (Tegaderm, 3 M) |
Liao | 2020 | RCT | China | 200/100 | PRP + SC | SC | NC | 1. Peripheral blood was centrifuged for 1.5 min. 2. It was delivered by autologel system | PRP gel applied on ulcers covered with vapor-permeable film (Tegaderm, 3 M) |
Elsaid | 2020 | RCT | Egypt | 24/12 | PRP + SC | SC | Wagner classification: I-IV | 1. Peripheral blood was centrifuged at 3600 rpm. 2. A second centrifugation at 2400 rpm | PRP gel applied on ulcer with Vaseline gauze, few layers of sterile gauze, and non-compressible bandage. This was repeated twice weekly |
Rainys | 2019 | RCT | Lithuania | 69/35 | PRP + SC | SC | NC | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | PRP gel applied on ulcer with contact layer dressing covered with non-absorbent foam dressing changed every 3–4 d |
Singh | 2018 | RCT | India | 55/29 | PRP + SC | SC | Ulcers that had exposed bone or bone, involvement were excluded | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | An appropriate amount of the PRP (approximately 3–4 ml of PRP for a 5 × 10 cm ulcer) was injected at various points along the wound edges once a week |
Ahmed | 2017 | RCT | Egypt | 56/28 | PRP + SC | SC | Texas classification: IA, IIA, IC, IIC | 1. Peripheral blood was centrifuged at 1500 rpm for 5 min. 2. A second centrifugation at 3500 rpm for 5 min | PRP gel applied on ulcers after irrigation with 0.9% saline twice weekly covered with non-absorbing dressing |
Karimi | 2016 | RCT | Iran | 50/25 | PRP + SC | SC | Wagner classification: I, II | Peripheral blood was centrifuged at 2000 rpm A for 10 min | PRP gel applied on ulcers covered with two pieces of dry sterile gauzes. PRP dressing was performed only once at the beginning of study |
Li | 2015 | RCT | China | 103/48 | PRP + SC | SC | Wagner classification: I, IV | 1. Peripheral blood was centrifuged for 1.5 min. 2. It was delivered by autologel System | Weekly topical application of PRP gel with covered with standard dressing changed weekly |
Li | 2012 | RCT | China | 117/59 | PRP + SC | SC | Wagner classification: I, II, III, IV, V | 1. Peripheral blood was centrifuged at 313 × g for 4 min 2. A second centrifugation at 1252 × g for 6 min | PRP gel applied on ulcers covered with two pieces of dry sterile gauzes. PRP dressing was performed only once at the beginning of study |
Saad Setta | 2011 | RCT | Egypt | 24/12 | PRP + SC | SC | Ulcers that had exposed tendons, ligaments or bone were excluded | 1. Peripheral blood was centrifuged at 1007 × g. 2. A second centrifugation at 477.5 × g | PRP gel applied on ulcers covered with Vaseline gauze and then a dressing. This was repeated twice weekly |
Jeong | 2010 | RCT | Korea | 100/52 | PRP + SC | PPP + SC | Texas classification: IA, IIA, IC, IIC | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | PRP gel applied on ulcers covered with two pieces of dry sterile gauzes. PRP dressing was performed only once at the beginning of study |
Friese | 2007 | RCT | Netherlands | 42/21 | PRP + SC | SC | Wagner classification: I, II, III | It was delivered by Harvest System (Harvest Technologies, Plymouth, MA) | PRP gel applied on ulcer every two weeks |
Kakagia | 2007 | RCT | Greece | 32/16 | PRP + SC | SC | NC | It was delivered by Gravitational Platelet Separation System (GPS, Biomet) | PRP gel applied on ulcers covered with vapor-permeable film (Tegaderm, 3 M) |
Driver | 2006 | RCT | USA | 72/40 | PRP + ORC/CB + SC | ORC/CB + SC | Texas classification: IA | 1. Peripheral blood was centrifuged for 1.5 min. 2. It was delivered by autologel System(AutoloGel, Cytomedix, Gaithersburg, MD | Weekly topical application of PRP gel with covered with standard dressing changed weekly |
Saldalamacchia | 2004 | RCT | Italy | 14/7 | PRP + SC | Saline gel + SC | Wagner classification: II, III | NC | Weekly topical application of PRP gel with covered with standard dressing changed weekly |
Steed | 1996 | RCT | USA | 36/18 | PRP + SC | SC | Wagner classification: I, II, III | Delivered by Gravitational Platelet Separation System (GPS, Biomet) | PRP gel applied on ulcers covered with Vaseline gauze and then a dressing. This was repeated twice weekly |
Steed | 1992 | RCT | USA | 13/7 | PRP + SC | SC | NC | Peripheral blood centrifuge at a rate of 2000–3200 rpm for 10–15 min | PRP gel applied on ulcer every two weeks |