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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Circ_0005615 restrains the progression of multiple myeloma through modulating miR-331-3p and IGF1R regulatory cascade

Fig. 5

IGF1R was a direct target of miR-331-3p. A The binding sites between IGF1R 3′UTR and miR-331-3p were exhibited by starbase. B, C The binding relationship between miR-331-3p and IGF1R was validated by dual-luciferase reporter assay. D IGF1R mRNA level was counted in MM patients and healthy volunteers by qRT-PCR. E The correlation between IGF1R and miR-331-3p was determined by Pearson correlation analysis. F Western blot was performed for IGF1R protein detection in MM cells. ***P < 0.001, ****P < 0.0001

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