Fig. 1

Circ_0005615 was highly expressed in MM samples and cells. A Heat maps displaying the 13 up-regulated circRNAs in MM patients (GSE133058). Green showed low expression and red represented high expression. B QRT-qPCR was executed to examine the level of circ_0005615 in 26 pairs of MM samples and healthy volunteers. C QRT-qPCR analysis of circ_0005615 abundance in MM cells and normal nPCs cells. D–E After RNase R treatment, qRT-PCR was implemented to reveal the levels of circ_0005615 and linear RNA GAPDH in MM1.S and NCI-H929 cells. F, G Random and Oligo(dT)18 primers were utilized to measure the level of circ_0005615 and GAPDH in reverse transcription. **P < 0.01, ***P < 0.001, ****P < 0.0001