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Table 4 MDR analysis of the interaction of LRP5 gene rs41494349, rs2306862 with LRP6 gene rs10743980, rs2302685

From: LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women

Gene–gene interactions

 

Training balancing accuracy

Testing accuracy

OR (95% CI)

P-value

Cross-validation consistency

2

rs41494349&rs2306862

0.556

0.525

0.894 (0.319,2.509)

0.095

8/10

 

rs41494349&rs2302685

0.550

0.491

1.571 (0.924,2.672)

0.095

9/10

 

rs41494349&rs10743980

0.589

0.486

0.823 (0.405,1.673)

0.671

9/10

 

rs2306862&rs2302685

0.535

0.492

2.478 (0.274,22.419)

0.419

9/10

 

rs2306862&rs10743980

0.593

0.547

1.462 (1.128,1.895)

0.004**

9/10

 

rs2302685&rs10743980

0.601

0.571

0.917 (0.329,2.557)

0.869

10/10

3

rs41494349&rs2302685&rs10743980

0.627

0.475

1.504 (1.092,2.073)

0.013*

10/10

 

rs41494349&rs2306862&rs2302685

0.552

0.521

0.458 (0.060,3.513)

0.452

10/10

 

rs2306862&rs2302685&rs10743980

0.579

0.567

0.504 (0.800,3.167)

0.465

9/10

4

rs10743980&rs2302685&rs2306862&rs41494349

0.624

0.531

2.763 (0.493,15.506)

0.248

10/10

  1. SNP single-nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. Adjusted for age and menopausal years
  3. Italicized value is statistically significant, *P < 0.05, **P < 0.01 indicates statistical significance
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X