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Table 4 Baseline characteristics of included studies

From: Platelet-rich plasma injection for the treatment of ankle osteoarthritis: a systematic review and meta-analysis

Author

Country

Year

Design

Mean age (y)

OA, primary (N)

Severe OA

Takakura/ KL 3–4 (%)

PRP

(N)

Comparator

(N)

Male (%)

FU

Time

(week)

Outcome

Angthong [30]

Thailand

2013

Retrospective

Before–after descriptive

50.8

5, NA

20

5

No

60

192

VAS-FA

SF-36

Fukawa [12]

Japan

2017

Prospective

Before–after descriptive

59.3

20, 20

10

20

No

25

24

VAS

JSSF

SAFE-Q

Repetto [29]

Italy

2017

Retrospective

Before–after descriptive

57.5

20, 0

100

20

No

60

212

VAS

FADI

Paget [11]

Netherlands

2021

RCT

55.6

100, 1

100

48

Placebo

(52)

54

26

VAS

AOFAS

FAO

AOS

AAS

SF-36

EQ5D3L

Sun [13]

Taiwan

2021

Prospective

Before–after descriptive

55.5

39, NA

28.2

39

No

43

24

VAS

AOFAS

AOS

  1. OA osteoarthritis, NA not available, KL Kellgren–Lawrence, PRP platelet-rich plasma, FU follow up, RCT randomised controlled trial, VAS-FA visual analog scale foot and ankle, SF-36 the 36-Item Short Form Health Survey, VAS visual analog scale, JSSF the Japanese Society for Surgery of the Foot ankle/hindfoot scale, SAFE-Q the Self-Administered Foot Evaluation Questionnaire, FADI the Foot and Ankle Disability Index, AOFAS the American Orthopaedic Foot and Ankle Society score, FAO Foot and Ankle Outcome Score, AOS Ankle Osteoarthritis Score, AAS Ankle Activity Score (AAS), EQ5D3L The 3-Level EuroQol 5-Dimension (EQ-5D-3L)