Fig. 8

FLRT2 could counteract the effects of miR-7-5p inhibition on IL-1β-treated chondrocytes. A FLRT2 expression was promoted in chondrocytes transfected with miR-7-5p inhibitor and restored in chondrocytes co-transfected with miR-7-5p inhibitor and si-FLRT2. *P < 0.05, **P < 0.01; ns, not significant. B–D The suppression of FLRT2 could neutralize the effects of miR-7-5p inhibition on the viability (B) and apoptosis (C–D) of IL-1β-treated chondrocytes. **P < 0.01; ns, not significant. E Relative expression levels of FLRT2, MMP13, ADAMTS5, Collagen II, and Aggrecan after transfection were detected by western blot analysis. **P < 0.05; ns, not significant