Fig. 5

miR-7-5p could neutralize the effects of ZFAS1 overexpression on IL-1β-treated chondrocytes. A qRT-PCR detection of miR-7-5p expression. **P < 0.01, compared with the control group; ^##P < 0.01, compared with IL-1β group; ^aaP < 0.01, compared with IL-1β + ZFAS1 group; ^bP < 0.05, compared with IL-1β + sh-ZFAS1 group. B Effects of ZFAS1 and miR-7-5p on the cell viability of IL-1β-treated chondrocytes. **P < 0.01, compared with the control group; ^#P < 0.05, ^##P < 0.01, compared with IL-1β group; ^aaP < 0.01, compared with IL-1β + ZFAS1 group; ^bP < 0.05, compared with IL-1β + sh-ZFAS1 group. C–D Effect of ZFAS1 and miR-7-5p on the cell apoptosis of IL-1β-treated chondrocytes. **P < 0.01, compared with the control group; ^##P < 0.01, compared with IL-1β group; ^aP < 0.05, compared with IL-1β + ZFAS1 group; ^bbP < 0.01, compared with IL-1β + sh-ZFAS1 group. D Relative expression levels of MMP13, ADAMTS5, Collagen II, and Aggrecan after cell transfection were detected by western blot. **P < 0.01, compared with the control group; ^#P < 0.05, ^##P < 0.01, compared with IL-1β group; ^aP < 0.05, ^aaP < 0.01, compared with IL-1β + ZFAS1 group; ^bP < 0.05, ^bbP < 0.01, compared with IL-1β + sh-ZFAS1 group