Research hotspots and trends of microRNAs in intervertebral disc degeneration: a comprehensive bibliometric analysis

Table 6 miRNAs involved in the process of IDD

MiRNA	Experimental models	Targets	Expression	Effect on IDD	References
miRNAs involved in NPC apoptosis in IDD
miR-155	Human NPC	FADD, Caspase-3	Downregulated	Promotion	[22]
miR-15a	Human NP tissues	MAP3K9	Upregulated	Promotion	[27]
miR-573	Human NPC	Bax, Bcl-2, Caspase-3	Upregulated	Inhibition	[28]
miR-210	Human NP tissues	HOXA9	Downregulated	Inhibition	[29]
miR-499a-5p	Human NPC	SOX, TNF-α	Downregulated	Inhibition	[30]
miRNAs involved in NPC proliferation in IDD
miR-10b	Human NP tissues	HOXD10, RhoC, Akt	Upregulated	Promotion	[31]
miR-21	Human NP tissues	PTEN, Akt	Upregulated	Promotion	[32]
miR-96	Human NPC	ARID2, Akt	Upregulated	Promotion	[33]
miRNAs involved in the ECM degradation
miR-100	Human NP SV40 cell line	FGFR3	Upregulated	Promotion	[34]
miR-93	Human NP tissues	MMP-3	Downregulated	Promotion	[35]
miR-15b	Human NP tissues	SMAD3, IL-1β	Upregulated	Promotion	[36]
miRNAs involved in the CEP degeneration
miR-34a	Human degenerative CEP tissues	Bcl-2, Fas	Upregulated	Promotion	[37]
miR-20a	Human degenerative CEP tissues	ANKH	Upregulated	Inhibition	[38]
miR-221	Human IDD CEP	ERα	Upregulated	Promotion	[39]
miRNAs involved in inflammation in IDD
miR-181a	Rat NPC	TRAIL	Downregulated	Inhibition	[40]
miR-149	LPS-stimulated NPC	MMP3, ADAMTS, TNF-α, IL-1, IL-6	Downregulated	Inhibition	[41]
miR-15b	Human NP tissues	SMAD3, IL-1β	Upregulated	Promotion	[36]

miRNAs microRNAs; IDD Intervertebral disc degeneration; NP Nucleus pulposus; NPC NP cell; IDD Intervertebral disc degeneration; ECM Extracellular matrix; FADD Fas-associating protein with a novel death domain; MAP3K9 Mitogen-activated protein 3 kinase 9; Bcl-2 B-cell lymphoma-2; Bax BCL-2-associated X protein; HOXA9 Homeobox A9; SOX Sex-determining region Y-box; LPS Lipopolysaccharide; ERα Estrogen receptor α

ISSN: 1749-799X